Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.010 Biomarker disease BEFREE Our results show that RbAp48 is a NF-kappaB-regulated gene playing an important role in thyroid cancer cell autonomous proliferation. 17244783 2007
CUI: C0206708
Disease: Cervical Intraepithelial Neoplasia
Cervical Intraepithelial Neoplasia 		0.010 AlteredExpression disease BEFREE Among them, retinoblastoma-binding protein 4 (RbAp48) was selected, and its differentiation expression was verified with both additional cervical cancer-derived cell lines and human tissues of cervical intraepithelial neoplasia and cervical cancer. 17616526 2007
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.010 Biomarker disease BEFREE Our results show that RbAp48 is a NF-kappaB-regulated gene playing an important role in thyroid cancer cell autonomous proliferation. 17244783 2007
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.010 Biomarker group BEFREE To biologically validate our classifier, we transfected RbAp48 into three cancer cell lines (HS-578T, MALME-3M, and MDA-MB-231). 16103067 2005
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia 		0.010 Biomarker disease BEFREE Specifically, c-MYB (P </= 0.04) was significantly increased in ALL in the total fraction, whilst HOXA9 (P </= 0.19) and cystatin c (P </= 0.01) were increased in AML in the CD34(+) and CD34(-) fractions, respectively. c-MYB, hSNF2, RBAP48, HKRT-1, LYN, CD33, Adipsin and HOXA9 were increased in AML compared with remission AML, indicating an ability to determine disease activity. 16029452 2005
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.010 Biomarker disease BEFREE Specifically, c-MYB (P </= 0.04) was significantly increased in ALL in the total fraction, whilst HOXA9 (P </= 0.19) and cystatin c (P </= 0.01) were increased in AML in the CD34(+) and CD34(-) fractions, respectively. c-MYB, hSNF2, RBAP48, HKRT-1, LYN, CD33, Adipsin and HOXA9 were increased in AML compared with remission AML, indicating an ability to determine disease activity. 16029452 2005
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.010 Biomarker group BEFREE To biologically validate our classifier, we transfected RbAp48 into three cancer cell lines (HS-578T, MALME-3M, and MDA-MB-231). 16103067 2005
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.010 GeneticVariation disease BEFREE The genes encoding Beclin 1, RbAp48, Pir51 and aldolase b are first reported that may be related with hepatocarcinoma. 14966907 2004
CUI: C0041341
Disease: Tuberous Sclerosis
Tuberous Sclerosis 		0.010 AlteredExpression disease LHGDN Regulation of PCNA and CAF-1 expression by the two tuberous sclerosis gene products. 12893285 2003
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.020 Biomarker disease BEFREE In the present study, we showed that RBBP4 plays a negative regulatory role during HIV-1 infection. 31435636 2019
CUI: C3854222
Disease: Human immunodeficiency virus (HIV) II infection category B1
Human immunodeficiency virus (HIV) II infection category B1 		0.020 Biomarker disease BEFREE In conclusion, our results establish RBBP4 as a new potent antiretroviral factor, which may provide theoretical basis for the treatment of HIV in the future. 31435636 2019
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.020 AlteredExpression disease BEFREE For this purpose, we demonstrated in the present study that RbAp48 expression was upregulated by HIV-1 infection, whereas the knockdown of RbAp48 promoted HIV infection and the production of virus particles. 27222146 2016
CUI: C3854222
Disease: Human immunodeficiency virus (HIV) II infection category B1
Human immunodeficiency virus (HIV) II infection category B1 		0.020 Biomarker disease BEFREE However, the role of RbAp48 in human immunodeficiency virus type 1 (HIV-1) infection and gene replication has not been determined to date, to the best of our knowledge. 27222146 2016
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.020 AlteredExpression disease BEFREE Indeed, transgenic expression of the RbAp48 gene induced apoptosis in the exocrine glands, resulting in the development of autoimmune exocrinopathy resembling Sjögren's syndrome (SS). 20635899 2010
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.020 AlteredExpression disease BEFREE In this study, we report that transgenic (Tg) expression of RbAp48 resulted in the development of autoimmune exocrinopathy resembling Sjögren's syndrome. 19015307 2008
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.020 AlteredExpression disease LHGDN Expression of the retinoblastoma protein RbAp48 in exocrine glands leads to Sjögren's syndrome-like autoimmune exocrinopathy. 19015307 2008
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.030 AlteredExpression phenotype BEFREE Blocking the interaction between ARMC12 and RBBP4 by cell-penetrating inhibitory peptide activates the downstream gene expression and suppresses the tumorigenesis and aggressiveness of NB cells. 30026490 2018
CUI: C0853662
Disease: Oestrogen deficiency
Oestrogen deficiency 		0.030 AlteredExpression disease BEFREE Zileuton caused downregulation of Rbbp4 in the hippocampus and had an effect on bone healing, changed the expression of genes involved in cross talk between bones and brain, and may be a potent drug for further examination in estrogen deficiency-related dysfunction(s). 28860177 2018
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix 		0.030 Biomarker disease BEFREE RbAp48 may be a therapeutic target that may help to improve the treatment of cervical cancer. 28138695 2017
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma 		0.030 Biomarker disease BEFREE RbAp48 may be a therapeutic target that may help to improve the treatment of cervical cancer. 28138695 2017
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.030 Biomarker disease BEFREE RbAp48 may be a therapeutic target that may help to improve the treatment of cervical cancer. 28138695 2017
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.030 Biomarker phenotype BEFREE Globally, RBBP4 positively and negatively regulates genes involved in critical cellular functions including tumorigenesis. 26972001 2016
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix 		0.030 Biomarker disease BEFREE RbAp48 may be a potential target to improve the results of radiation therapy for patients with cervical cancer. 23756179 2013
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma 		0.030 Biomarker disease BEFREE RbAp48 may be a potential target to improve the results of radiation therapy for patients with cervical cancer. 23756179 2013
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.030 Biomarker phenotype BEFREE This promoting effect of hPuf-A in tumorigenesis might be correlated with the regulation of its associated mRNAs, such as RbAp48 and DDX3. 23625657 2013