|
Colitis
|
0.550 |
AlteredExpression
|
disease |
BEFREE |
Using a SOCS2<sup>-/-</sup> mice model of colitis we show that SOCS2-deficiency is pro-inflammatory and negatively correlates with NDR1 and nuclear p65 levels.
|
28216640 |
2017 |
|
Colitis
|
0.550 |
Biomarker
|
disease |
BEFREE |
In conclusion, the present study demonstrated that EEN attenuated DSS‑ and TNBS‑induced colitis by inhibiting p65 activation via regulating the p38/MSK1 pathway, thus suggesting that EEN is effective in the treatment of colitis.
|
29901086 |
2018 |
|
Colitis
|
0.550 |
Biomarker
|
disease |
BEFREE |
Local administration of p65 antisense phosphorothioate oligonucleotides abrogated clinical and histological signs of colitis and was more effective in treating TNBS-induced colitis than single or daily administration of glucocorticoids.
|
8782457 |
1996 |
|
Colitis
|
0.550 |
Biomarker
|
disease |
BEFREE |
The aims of this study are to enhance bioavailability and investigate their impact on nuclear p65 and HIF-1α for the first time in experimental colitis.Dextran sulphate sodium was used to induce colitis in mice and effect of either free CAPE/PIC or CAPE/PIC loaded albumin nanoparticles treatment was observed on disease development and levels of cellular p65 and HIF-1α.Our results indicate that albumin nano-encapsulation of CAPE/PIC not only enhances its anti-inflammatory potential but also potentiates its ability to effectively modulate inflammation related biomolecular pathways.
|
30430451 |
2019 |
|
Colitis
|
0.550 |
Biomarker
|
disease |
RGD |
Effects of glutamine on proinflammatory gene expression and activation of nuclear factor kappa B and signal transducers and activators of transcription in TNBS-induced colitis.
|
18623154 |
2008 |
|
Colitis
|
0.550 |
AlteredExpression
|
disease |
BEFREE |
The chitosan/pUNO-SIGIRR nanoparticles attenuated colonic tissue inflammation through the inhibition of TLR4/NF-κB overactivation by downregulating TLR4, MyD88 and NF-κB p65 expression in a mouse model of colitis.
|
28153604 |
2017 |
|
Colitis
|
0.550 |
Biomarker
|
disease |
CTD_human |
The role of cholinergic anti-inflammatory pathway in acetic acid-induced colonic inflammation in the rat.
|
23810507 |
2013 |
|
Kidney Failure, Chronic
|
0.510 |
Biomarker
|
disease |
RGD |
Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction.
|
18077597 |
2008 |
|
Kidney Failure, Chronic
|
0.510 |
AlteredExpression
|
disease |
BEFREE |
Phosphorylated NF-κB p65 was expressed and colocalized with p53, p21, β-galactosidase, TGF-β1, and α-SMA in the kidneys of chronic renal failure (CRF) rats.
|
21832251 |
2011 |
|
Kidney Failure, Chronic
|
0.510 |
Biomarker
|
disease |
CTD_human |
Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failure.
|
19420110 |
2009 |
|
Diabetes Mellitus, Experimental
|
0.500 |
Biomarker
|
disease |
RGD |
Diabetes-induced atrophy is associated with a muscle-specific alteration in NF-kappaB activation and expression.
|
18633731 |
2008 |
|
Diabetes Mellitus, Experimental
|
0.500 |
Biomarker
|
disease |
RGD |
Effect of early insulin therapy on nuclear factor kappaB and cytokine gene expressions in the liver and skeletal muscle of high-fat diet, streptozotocin-treated diabetic rats.
|
18500427 |
2008 |
|
Diabetes Mellitus, Experimental
|
0.500 |
Biomarker
|
disease |
CTD_human |
Taurine exerts hypoglycemic effect in alloxan-induced diabetic rats, improves insulin-mediated glucose transport signaling pathway in heart and ameliorates cardiac oxidative stress and apoptosis.
|
22138235 |
2012 |
|
Ependymoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A De Novo Mouse Model of C11orf95-RELA Fusion-Driven Ependymoma Identifies Driver Functions in Addition to NF-κB.
|
29949764 |
2018 |
|
Ependymoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Although no recurrently mutated genes were found throughout these groups of ependymomas, PFA exhibited a CpG island methylator phenotype, PFB was associated with extensive chromosomal aberrations, and the C11orf95-RELA fusion gene was frequently observed in supratentorial ependymomas.
|
25182241 |
2014 |
|
Ependymoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Among the p53-positive ependymomas, the vast majority exhibited a RELA fusion leading to the hypothesis that p53 inactivation might be linked to RELA positivity.In order to assess the potential of p53 reactivation through MDM2 inhibition in ependymoma, we evaluated the effects of Actinomycin-D and Nutlin-3 treatment in two preclinical ependymoma models representing the high-risk subtypes PF-EPN-A and ST-EPN-RELA.
|
27556362 |
2016 |
|
Ependymoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our previously reported ALK rearrangements and the RELA and YAP1 fusions found in supratentorial ependymomas were until now the only known fusion genes present in ependymal tumors.
|
27401149 |
2016 |
|
Ependymoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
A novel recurrent oncogenic fusion involving the C11orf95 and RELA genes was recently described in supratentorial ependymomas.
|
27121356 |
2016 |
|
Ependymoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Although most CEs in our group were immunopositive for L1CAM and showed C11orf95-RELA fusion, which have been associated with a poor prognosis in supratentorial ependymomas, all our patients had good outcomes.
|
31150846 |
2019 |
|
Ependymoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
C11orf95-RELA fusion proteins translocated spontaneously to the nucleus to activate NF-κB target genes, and rapidly transformed neural stem cells--the cell of origin of ependymoma--to form these tumours in mice.
|
24553141 |
2014 |
|
Ependymoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The present finding indicates that the TP53 p.R337H germline mutation is uncommon in patients with EPN in Brazil and screening of pediatric patients RELA fusion EPN may be informative to better understand the role of TP53 germline mutations in the development and prognosis of these tumors.
|
31728854 |
2020 |
|
Ependymoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
We describe a novel RELA-fusion composed by a chimeric transcript C11orf95-LOC-RELA in a supratentorial WHO grade II EPN occurring in a 4-year-old child.
|
30631904 |
2019 |
|
Ependymoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Molecular characteristics are also important for the diagnosis of several other CNS tumors, such as RELA fusion-positive subtype of ependymoma, atypical teratoid rhabdoid tumor (AT/RT), embryonal tumor with multilayered rosettes, and solitary fibrous tumor/hemangiopericytoma.
|
31124566 |
2019 |
|
Ependymoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
However, the pathogenesis of RELA fusion-negative ependymomas remains elusive.
|
30514397 |
2018 |
|
Ependymoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
ST-EPNs harbouring RELA fusions showed frequent grade III histology (81.5%), clear cell morphology (70.3%), upregulated NFKB1 expression, MIB-1 labelling indices (LI) ≥ 10% (77.8%), and immunopositivity for nestin (95.7%), VEGF (72%), L1CAM (79%), and p53 (64%).
|
29354850 |
2018 |