|
Abnormal cell morphology
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abscess
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, IL-8 and TNF-alpha expression and nuclear phosphorylated NF-kappaB p65 expression could be immunohistochemically confirmed in inflamed epithelium with cryptitis or crypt abscess in UC patients.
|
19369513 |
2009 |
|
Acquired Immunodeficiency Syndrome
|
0.010 |
Biomarker
|
group |
BEFREE |
The protein expression levels of RAS, RAF, nuclear factor (NF)-κB P65 and P50 as well as inhibitor of NF-κB-α of the TLR4 signaling pathway in AIDS-KS and KS tissues were higher than those in normal tissues.
|
30651761 |
2019 |
|
Acute Chest Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Two miRNAs (hsa-miR-29 and hsa-miR-1) and three TFs (NFIC, NFKB1 and RELA) were critical genes involved in pathological process of ACS.
|
31550669 |
2019 |
|
Acute colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The immunohistochemical expression of two transcription factors hypoxia-inducible factors-1α and nuclear factor-κB p65 has already been described in several disorders, including wound healing, asthma and chronic obstructive lung disease, rheumatoid arthritis, cancer, inflammatory bowel disease, and acute colitis.
|
29932372 |
2018 |
|
Acute Erythroblastic Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Administration of the p65 inhibitor parthenolide significantly improved hematology and myelogram indices while prolonging the life span of erythroleukemia mice.
|
26378023 |
2015 |
|
Acute Erythroblastic Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Fusion of ZMYND8 and RELA genes in acute erythroid leukemia.
|
23667654 |
2013 |
|
Acute lymphocytic leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
On the basis of this technique we analyzed p65 gene expression in various types of leukemia: acute myeloblastic leukemia (AML) (n=26); acute lymphoblastic leukemia (ALL) (n=26) and chronic lymphocytic leukemia (CLL) (n=40).
|
12458326 |
2002 |
|
Acute monocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
All these findings suggest that NF-κB p65 maybe an attractive candidate for the therapeutic targeting of acute monocytic leukemia.
|
21901538 |
2012 |
|
Acute myocardial infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Treatment with dabigatran significantly inhibited the P65 of nuclear factor κB, tumor necrosis factor α, interleukin (IL)‑1β and IL‑6 activities and significantly enhanced the catalase and superoxide dismutase activities in the AMI rabbits.
|
29115615 |
2018 |
|
Acute pancreatitis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
High protein levels of the NF‑κB p65 subunit were observed in the nuclei of cells in the resistin‑treated AP model, compared with the untreated AP model.
|
27959400 |
2017 |
|
Acute pancreatitis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In the MaR1-treated AP mice, inflammation of the pancreas and the expression of inflammatory cytokines, pancreatic acinar cell apoptosis, Bcl-2 expression, and expression of TLR4, MyD88, and p-NF-kappaB p65 were reduced, but Bax, cleaved caspase-3, and cleaved caspase-9 expression increased.
|
31671079 |
2019 |
|
Acute pancreatitis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Obesity reduces pancreatic PGC-1α levels and potentiates not only oxidative but also IL-6-mediated inflammatory damage during acute pancreatitis by relieving the binding of PGC-1α to the NF-κB subunit p65.
|
30570131 |
2019 |
|
Acute Promyelocytic Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
In the present work, we have found that capsaicin suppresses TPA-stimulated activation of NF-kappaB through inhibition of IkappaB alpha degradation and blockade of subsequent nuclear translocation of p65 in human promyelocytic leukemia HL-60 cells.
|
12214859 |
2002 |
|
Acute Promyelocytic Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
TNFα-treated PML<sup>-/-</sup> cells show normal IκBα degradation and NF-κB nuclear translocation but significantly reduced NF-κB DNA binding and phosphorylation of NF-κB p65.
|
28317833 |
2017 |
|
Acute respiratory distress
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The protective effect of special electromagnetic field treated water and far infrared rays on endotoxin-induced acute respiratory distress syndrome may result from their role in reducing the levels of IL-1<i>β</i> and IL-6 in serum and the expression level of p65 protein in lung tissue, in addition to reliving inflammatory response, lung coefficient, and lungs edema.
|
31281400 |
2019 |
|
Acute Undifferentiated Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The NF-κB subunit RELA occupies promoter regions of crucial MLL target genes and sustains the MLL-dependent leukemia stem cell program.
|
24054986 |
2013 |
|
Adenocarcinoma
|
0.060 |
AlteredExpression
|
group |
BEFREE |
In adenocarcinomas the NF-kappaB p65 expression level was significantly higher in advanced TNM stages (III-IV) than in earlier stages (I-II) (P<.0001), and when NF-kappaB p65 is dichotomized using 50% as the cutoff point (high vs low), a higher NF-kappaB p65 expression level was detected in tumors having either K-RAS (P = .02) or EGFR (P = .009) mutations compared with wildtype tumors.
|
17078054 |
2006 |
|
Adenocarcinoma
|
0.060 |
AlteredExpression
|
group |
LHGDN |
Frequent OPN expression is typical of, but not specific for MM, whereas it appears to select adenocarcinoma cases with p65 and MMP-9 expression, suggesting a link with EGFR signalling pathways.
|
17493236 |
2007 |
|
Adenocarcinoma
|
0.060 |
AlteredExpression
|
group |
BEFREE |
RelA, the p65 subunit of NF-kappa B, was constitutively activated in approximately 67% (16 of 24) of pancreatic adenocarcinomas but not in normal pancreatic tissues.
|
9918209 |
1999 |
|
Adenocarcinoma
|
0.060 |
AlteredExpression
|
group |
LHGDN |
Nuclear factor-kappaB/p65 (Rel A) is constitutively activated in human prostate adenocarcinoma and correlates with disease progression.
|
15256061 |
2005 |
|
Adenocarcinoma
|
0.060 |
AlteredExpression
|
group |
BEFREE |
All cases of adenocarcinoma showed strong expression of both RELA and NFκB-1.
|
26990751 |
2017 |
|
Adenocarcinoma
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Paraffin sections of normal epithelial, adenomatous and adenocarcinoma tissues were analysed immunohistochemically for expression of RelA, Bcl-2 and Bcl-x(L) proteins.
|
15484295 |
2004 |
|
Adenocarcinoma
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Frequent OPN expression is typical of, but not specific for MM, whereas it appears to select adenocarcinoma cases with p65 and MMP-9 expression, suggesting a link with EGFR signalling pathways.
|
17493236 |
2007 |
|
Adenocarcinoma of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that NFE2L3 expression is regulated by the RELA subunit of NF-κB and that NFE2L3 levels are elevated in patients with colon adenocarcinoma when compared with normal adjacent tissue.
|
31693889 |
2019 |