RELA, RELA proto-oncogene, NF-kB subunit, 5970

N. diseases: 483; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0014474
Disease: Ependymoma
Ependymoma
0.500 Biomarker disease HPO
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.450 Biomarker group HPO
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.130 Biomarker group HPO
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.130 Biomarker disease HPO
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.110 Biomarker group HPO
CUI: C0030193
Disease: Pain
Pain
0.110 Biomarker phenotype HPO
CUI: C0036572
Disease: Seizures
Seizures
0.110 Biomarker phenotype HPO
CUI: C0037930
Disease: Spinal Cord Neoplasms
Spinal Cord Neoplasms
0.100 Biomarker group HPO
CUI: C0038874
Disease: Supratentorial Neoplasms
Supratentorial Neoplasms
0.100 Biomarker group HPO
CUI: C0042963
Disease: Vomiting
Vomiting
0.100 Biomarker phenotype HPO
CUI: C0149745
Disease: Oral Ulcer
Oral Ulcer
0.100 Biomarker disease HPO
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.100 Biomarker group HPO
CUI: C0392699
Disease: Dysesthesia
Dysesthesia
0.100 Biomarker phenotype HPO
CUI: C0427065
Disease: Distal muscle weakness
Distal muscle weakness
0.100 Biomarker phenotype HPO
CUI: C0575081
Disease: Gait abnormality
Gait abnormality
0.100 Biomarker group HPO
CUI: C4476793
Disease: Abnormal cell morphology
Abnormal cell morphology
0.100 Biomarker phenotype HPO
CUI: C4551915
Disease: Gait Disturbance, CTCAE
Gait Disturbance, CTCAE
0.100 Biomarker phenotype HPO
CUI: C0007766
Disease: Intracranial Aneurysm
Intracranial Aneurysm
0.010 AlteredExpression disease BEFREE <b>Results:</b> Reduced expression of Apc and IκBα, and increased expression of NF-κB p65 were found in IA tissues. 30808715 2019
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.020 PosttranslationalModification disease BEFREE <i>In vitro</i> expression of the TRAF6 protein, phosphorylated transcription factor p65 and phosphorylated p100 in myeloma cell lines was induced by MSCs from patients with MM. 28789366 2017
CUI: C0153392
Disease: Malignant neoplasm of nasopharynx
Malignant neoplasm of nasopharynx
0.010 Biomarker disease BEFREE (-)-Epigallocatechin-3-gallate inhibits nasopharyngeal cancer stem cell self-renewal and migration and reverses the epithelial-mesenchymal transition via NF-κB p65 inactivation. 25487615 2015
CUI: C0238301
Disease: Cancer of Nasopharynx
Cancer of Nasopharynx
0.010 Biomarker disease BEFREE (-)-Epigallocatechin-3-gallate inhibits nasopharyngeal cancer stem cell self-renewal and migration and reverses the epithelial-mesenchymal transition via NF-κB p65 inactivation. 25487615 2015
Human immunodeficiency virus (HIV) II infection category B1
0.010 Biomarker disease BEFREE (2008) report that the human immunodeficiency virus (HIV) transactivator Tat inhibits the SIRT1 deacetylase, resulting in increased acetylation of the NF-kappaB p65 subunit and subsequently in T cell hyperactivation. 18342601 2008
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.100 PosttranslationalModification disease BEFREE 3'-Sialyllactose as an inhibitor of p65 phosphorylation ameliorates the progression of experimental rheumatoid arthritis. 30152858 2018
CUI: C0014060
Disease: Encephalitis, St. Louis
Encephalitis, St. Louis
0.010 AlteredExpression disease BEFREE SLE T cells have been shown to display low levels of the p65 subunit of the NF-kappaB transcription factor and decreased production of IL-2. 12027419 2002
CUI: C0243026
Disease: Sepsis
Sepsis
0.250 AlteredExpression disease BEFREE Septicemia with multiorgan failure is associated with chronic activation of cytosolic NF-kappaB with translocation and accumulation of increased levels of nuclear p65 in blood leukocytes. 15972680 2005