Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although the full agonist effects of brain-derived neurotrophic factor and tropomyosin receptor kinase B activation in epilepsy models have been controversial, the present results indicate that such trophic activation by a partial agonist may potentially serve as an effective therapeutic option for prophylactic treatment of posttraumatic epileptogenesis, and treatment of other neurological and psychiatric disorders whose pathogenesis involves impaired parvalbumin interneuronal function.
|
29408225 |
2018 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, an obvious decrease in the PSD95 and BDNF expression levels of epileptic A1R KO mice was observed 7 days after complete kindling.
|
28492982 |
2018 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
We targeted those publications addressing both in vitro and in vivo evidences of relationship between BDNF and epilepsy.
|
30262417 |
2018 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Rats with epilepsy presented decreased BDNF levels compared with control rats.
|
29098710 |
2018 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, ECB device-mediated long-term supplementation of BDNF in the epileptic tissue may represent a valid therapeutic strategy against epilepsy and some of its co-morbidities.
|
29766029 |
2018 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that the protection against neuronal loss in specific limbic regions and overexpressed BDNF in the mossy fibers resulting from the repeated treatment with Ago and LCM, respectively, during SE is not a prerequisite for alleviation of epileptogenesis and development of epilepsy.
|
30738136 |
2019 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Compared with miR-103a inhibitors alone, epilepsy rats treated with BDNF-siRNA combined with miR-103a inhibitors significantly increased expression of GFAP in hippocampal tissues of epilepsy rats, increased number of apoptotic neurons and significantly decreased the number of surviving neurons.
|
31049031 |
2019 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
The current review is an attempt to collate the available preclinical and clinical studies to establish the therapeutic potential of various dietary flavonoids in comprehensive management of epilepsy with relation to CREB-BDNF pathway.
|
31400269 |
2019 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Silencing lncRNA PVT1 inhibits activation of astrocytes and increases BDNF expression in hippocampus tissues of rats with epilepsy by downregulating the Wnt signaling pathway.
|
30805931 |
2019 |
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Downregulated hippocampal expression of brain derived neurotrophic factor and tyrosine kinase B in a rat model of comorbid epilepsy and depression.
|
30741614 |
2019 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
We previously found that neurons respond to prolonged BDNF exposure (both in vivo (in models of epilepsy and TBI) and in vitro (in BDNF treated primary neuronal cultures)) by activating the Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) signaling pathway.
|
31455240 |
2019 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
This retrospective cross-sectional study provides preliminary evidence for a genetic basis of psychiatric comorbidities in epilepsy and suggests that BDNF and COMT may play an important role in the pathophysiology of mental health problems in this vulnerable population.
|
30909076 |
2019 |
Epilepsy
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thereafter, we discuss aspiring strategies for targeting BDNF/TrkB signaling so as to prevent epilepsy following an insult or suppress its expression once developed.
|
31377199 |
2020 |