|
Middle Cerebral Artery Occlusion
|
0.360 |
Biomarker
|
disease |
BEFREE |
<b>Methods:</b> Using the middle cerebral artery occlusion (MCAO) model of ischemic stroke, we identified that CCL2 is one of the most highly expressed chemokines in the ipsilateral hemisphere.
|
30613272 |
2018 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
<b>Patients & methods:</b> Reflex tears collected from 84 PD and 84 age- and sex-equivalent healthy controls (HC) were used to measure levels of oligomeric α-Syn (α-Syn<sub>Oligo</sub>), total α-Syn (α-Syn<sub>Total</sub>), CCL2, DJ-1, lactoferrin and MMP9.
|
31552762 |
2019 |
|
Neuralgia
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
<b>Results</b>: PRP significantly alleviated allodynia in burn-induced neuropathic pain 4 weeks after treatment, and PTEN expression in the skin and spinal cord were significantly increased in group D compared with the group C. p-PTEN, p-mTOR, and CCL2 expression in neuron cells; p-p38 and p-NFκB expression in microglia; and p-JNK and p-NFκB activation in spinal astrocytes decreased significantly in the group D compared with the group C. <b>Conclusions</b>: PRP is effective in treating burn-induced neuropathic pain and may be used in clinical practice.
|
29483815 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
<b>Results:</b> LM-Dox exhibited tumor tropism in response to CCL2 produced by A549 lung tumor cells and lung tumor tissues resulting in a remarkably higher amount of tumor accumulation than the case of Lipo-Dox (~ 4-fold).
|
31660078 |
2019 |
|
Lung Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
<b>Results:</b> LM-Dox exhibited tumor tropism in response to CCL2 produced by A549 lung tumor cells and lung tumor tissues resulting in a remarkably higher amount of tumor accumulation than the case of Lipo-Dox (~ 4-fold).
|
31660078 |
2019 |
|
Glaucoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
<i>Conclusion:</i> In our experiments, glaucoma in FUS patients was associated with low levels of MCP-1 and MMP-9 in the AH, while expression of MMP-2, MMP-3, and TGFβ-1 increased.
|
31268809 |
2019 |
|
Fuchs' heterochromic cyclitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
<i>Conclusion:</i> In our experiments, glaucoma in FUS patients was associated with low levels of MCP-1 and MMP-9 in the AH, while expression of MMP-2, MMP-3, and TGFβ-1 increased.
|
31268809 |
2019 |
|
Aqueous Humor Disorders
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
<i>Conclusion:</i> In our experiments, glaucoma in FUS patients was associated with low levels of MCP-1 and MMP-9 in the AH, while expression of MMP-2, MMP-3, and TGFβ-1 increased.
|
31268809 |
2019 |
|
Hyperglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
<i>In vitro</i> experiments in rat macrophages showed that hyperglycemia treatment suppresses Nrf2 activation, resulting in oxidative stress with decreased expression of antioxidant genes, including NAD(P)H:quinone oxidoreductase 1 and heme oxygenase 1, together with increased secretion of proinflammatory cytokines, including interleukin 1β (IL1β), IL6, and monocyte chemoattractant protein-1.
|
31616304 |
2019 |
|
Hypoxia
|
0.200 |
Biomarker
|
phenotype |
RGD |
(1) Alveolar hypoxia (10% O(2) breathing, 60 minutes) produced a rapid (5-minute) increase in plasma MCP-1 concentrations in conscious intact rats but not in alveolar macrophage-depleted rats.
|
20813992 |
2011 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
(3) Diabetes and high fat diet, which lead to a significant increase in inflammatory molecules and cytokines, including MCP-1, which induces changes in podocyte cytoskeleton and nephrin loss.
|
19077682 |
2009 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
(3) Diabetes and high fat diet, which lead to a significant increase in inflammatory molecules and cytokines, including MCP-1, which induces changes in podocyte cytoskeleton and nephrin loss.
|
19077682 |
2009 |
|
Idiopathic pulmonary arterial hypertension
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
(6) Although prostacyclin therapy (3 months) showed clinical benefit, this therapy had no effect on sCD40L and increased MCP-1 levels in PAH patients, and prostacyclin enhanced MCP-1 in CD40L-stimulated endothelial cells.
|
15302794 |
2004 |
|
Anaplasia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
(iii) Fgf9 knockout in SCs promoted the dedifferentiation of SCs and delayed the infiltration of macrophages by decreasing Mcp1, Tnfα, Il1β levels and leaky blood-nerve-barrier (BNB) in WD.
|
31220553 |
2019 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
-2518A>G polymorphism of MCP-1 does not seem to contribute substantially to CAD in Han Chinese.
|
19332042 |
2009 |
|
Middle Cerebral Artery Occlusion
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
-MCP-1 and MIP-1alpha expression is increased after middle cerebral artery occlusion, and double-labeled immunostaining revealed that MCP-1 is colocalized with neurons and astrocytes.
|
11157195 |
2001 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
52 tumors (53%) contained iNKTs, and oligonucleotide microarray analysis of the iNKT(+) and iNKT(-) tumors revealed that the former expressed higher levels of CCL2/MCP-1, CXCL12/SDF-1, CCL5/RANTES, and CCL21/SLC.
|
15123743 |
2004 |
|
Nephritis
|
0.070 |
Biomarker
|
disease |
BEFREE |
54 SLE patients without nephritis, 35 with nephritis but without dialysis, and 4 with nephritis under dialysis exhibited stepwise increases in IL-23 (<i>p</i>=0.009) and MCP-1 (<i>p</i>=0.015).
|
27814627 |
2017 |
|
leukemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
9L cell lines stably expressing murine MCP-1 (9L-JE) and control cell lines expressing neomycin 3' phosphotransferase (9L-Neo) were generated by infection with a Moloney murine leukemia retroviral vector.
|
7489565 |
1995 |
|
Childhood Leukemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
9L cell lines stably expressing murine MCP-1 (9L-JE) and control cell lines expressing neomycin 3' phosphotransferase (9L-Neo) were generated by infection with a Moloney murine leukemia retroviral vector.
|
7489565 |
1995 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Respiratory syncytial virus (RSV) infection of airway epithelial cells stimulates the expression and secretion of a variety of cytokines including the chemotactic cytokines interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), and RANTES (regulated upon activation, normal T cell expressed and secreted).
|
11922866 |
2002 |
|
Epstein-Barr Virus Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
EBV infection and latent membrane protein 1 expression in HUVEC resulted in NF-kappaB activation and increased expression of the cytokines interleukin (IL)-1alpha, IL-1beta, and IL-6; the chemokines IL-8, monocyte chemotactic protein-1, and RANTES; and the adhesion molecules intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin.
|
15257037 |
2004 |
|
Adenomatous Polyposis Coli
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
APC significantly inhibited in vitro the expression of TNFalpha and MCP-1 from LI90 stellate cells.
|
16497622 |
2006 |
|
Atrial Premature Complexes
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
APC significantly inhibited in vitro the expression of TNFalpha and MCP-1 from LI90 stellate cells.
|
16497622 |
2006 |
|
melanoma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Melanoma susceptibility and progression: Association study between polymorphisms of the chemokine (CCL2) and chemokine receptors (CX3CR1, CCR5).
|
17169533 |
2007 |