|
Abnormal behavior
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The chemokine (C-X3-C motif) ligand 1 (CX3CL1), also named fractalkine (FKN), has been implicated in psychiatric disorders and functions as a novel adipocytokine.
|
27658415 |
2017 |
|
Abnormal behavior
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Our results provide new evidence that not only prenatal stress-induced behavioral disturbances but also changes of CXCL12 and their receptor and at less extend in CX3CL1-CX3CR1 expression may be normalized by chronic antidepressant drug treatment.
|
29163165 |
2017 |
|
Acute Chest Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
Transcoronary (TC) levels of chemokine ligand 2 (CCL2) and C-X3-C motif chemokine ligand 1 (CX3CL1) were significantly elevated in patients with ACS versus patients with SAP (P < 0.01).
|
31409556 |
2019 |
|
Acute Chest Syndrome
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
High levels of CX3CL1 and myeloperoxidase measured within one month post ACS are associated with increase of rIMT, r=0.38 (p< 0.0001) and r=0.41 (p< 0.0001) respectively.
|
28881821 |
2017 |
|
Acute monocytic leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CX3CL1 increased the expression of proinflammatory and proangiogenic factors in THP-1 monocytes (a human acute monocytic leukemia cell line) and in human primary myoblasts and myotubes.
|
26632602 |
2016 |
|
Acute myocardial infarction
|
0.020 |
Biomarker
|
disease |
BEFREE |
Prognostic value of fractalkine/CX3CL1 concentration in patients with acute myocardial infarction treated with primary percutaneous coronary intervention.
|
30352758 |
2019 |
|
Acute myocardial infarction
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The time course of myocardial FKN gene expression in mice has a pattern similar to sFKN change in AMI patients.
|
26049921 |
2015 |
|
Acute pancreatitis
|
0.200 |
Therapeutic
|
disease |
RGD |
Fractalkine upregulates inflammation through CX3CR1 and the Jak-Stat pathway in severe acute pancreatitis rat model.
|
22213034 |
2012 |
|
Acute pulmonary embolism
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the adenovirus-overexpression CX3CL1 vector aggravated the inflammatory changes in APE, which were improved by aspirin.
|
28487961 |
2017 |
|
Adenocarcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Interestingly, survival effects of CX3CL1 were only observed in patients with smoking history and adenocarcinoma (AD, log rank, P = 0.027), but not in patients with squamous cell carcinoma (SQ).
|
29380447 |
2018 |
|
Adenocarcinoma of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
The CX3CL1/CX3CR1 reprograms glucose metabolism through HIF-1 pathway in pancreatic adenocarcinoma.
|
23857671 |
2013 |
|
Adrenal Gland Pheochromocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression analysis of RET and the GDNF/GFRalpha-1 and NTN/GFRalpha-2 ligand complexes in pheochromocytomas and paragangliomas.
|
10998441 |
2000 |
|
Adult Acute Monocytic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CX3CL1 increased the expression of proinflammatory and proangiogenic factors in THP-1 monocytes (a human acute monocytic leukemia cell line) and in human primary myoblasts and myotubes.
|
26632602 |
2016 |
|
Adult Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Together, these data demonstrate that the CX3CL1 can reduce incidence and size of lymphoma in vivo through increased recruitment of activated NK cytotoxic cells.
|
14612547 |
2003 |
|
Adult Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
CX3CR1 has also shown to be involved in the homing to specific tissues that express the ligand, CX3CL1, in breast and prostate cancer and may thus be involved in dissemination of lymphoma.
|
18060687 |
2008 |
|
Adult Soft Tissue Sarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
High coexpression of CCL2 and CX3CL1 is gender-specifically associated with good prognosis in soft tissue sarcoma patients.
|
24676787 |
2014 |
|
Aganglionosis, Colonic
|
0.020 |
Biomarker
|
disease |
BEFREE |
Mutational analysis of RET/GDNF/NTN genes in children with total colonic aganglionosis with small bowel involvement.
|
10946353 |
2000 |
|
Aganglionosis, Colonic
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Relationship between the type of RET/GDNF/NTN or SOX10 gene mutations and long-term results after surgery for total colonic aganglionosis with small bowel involvement.
|
11685702 |
2001 |
|
Age related macular degeneration
|
0.030 |
Biomarker
|
disease |
BEFREE |
Certain chemokines, such as CCL2 and CX3CL1, appear to be crucial in subretinal microglia and macrophage accumulation observed in AMD, and participate in the development of retinal degeneration as well as in choroidal neovascularization.
|
21126357 |
2010 |
|
Age related macular degeneration
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Our data suggest that the M280 allele, a SNP resulting in aberrant CX3CR1 and CX3CL1 interaction, as well as lowered expression of macular CX3CR1, may contribute to the development of AMD.
|
15944936 |
2005 |
|
Age related macular degeneration
|
0.030 |
Biomarker
|
disease |
BEFREE |
Systemic monocytes, tissue resident macrophages, dendritic cells and microglia have specific roles in immune surveillance and maintenance of tissue homeostasis and are key regulator and effector cells of the local immune response to acute and chronic tissue injury.Two major signalling pathways that differentially define trafficking behaviour and activation of systemic and local myeloid cell populations in response to exogenous and endogenous inflammatory stimuli are the Ccl2-Ccr2 and the Cx3cl1-Cx3cr1 chemokine pathways.Alterations in these pathways have been implicated in controlling myeloid cell activation during normal ageing and in age-related retinal degenerations, including age-related macular degeneration (AMD).We review the evidence for how altered chemokine signalling in acute and chronic inflammatory conditions regulate local and systemic myeloid cell responses in the retina and how this may contribute to or attenuate pathology in inherited and age-related retinal diseases.
|
24664727 |
2014 |
|
Airway Obstruction
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The results demonstrated that elevated circulating CX3CL1 level is associated with the systemic inflammation, small airway obstruction, and CAT scores in COPD patients, suggesting that CX3CL1 may play crucial roles in the pathogenesis of COPD.
|
31629111 |
2020 |
|
Allergic Reaction
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression.
|
21625544 |
2011 |
|
Alloxan Diabetes
|
0.300 |
Biomarker
|
disease |
CTD_human |
Inflammation and apoptosis in aortic tissues of aged type II diabetes: amelioration with alpha-lipoic acid through phosphatidylinositol 3-kinase/Akt- dependent mechanism.
|
20388520 |
2010 |
|
Alzheimer disease, familial, type 3
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The expression of CX3CR1, CX3CL1 and the microglial phagocytic phenotype were studied in brain tissue samples from AD patients.
|
28810892 |
2017 |