|
Airway Obstruction
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The results demonstrated that elevated circulating CX3CL1 level is associated with the systemic inflammation, small airway obstruction, and CAT scores in COPD patients, suggesting that CX3CL1 may play crucial roles in the pathogenesis of COPD.
|
31629111 |
2020 |
|
Cicatrix, Hypertrophic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The four chemokines, CCL2, CCL4, CCL5, and CX3CL1, maintained a long-term high expression level during the formation of hypertrophic scars (P < 0.01).
|
31691483 |
2020 |
|
Memory impairment
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Transplantation of MSCs carrying CX3CL1 and Wnt3a (CX3CL1-Wnt3a-MSC) significantly attenuated the learning and memory impairment when compared with a control group.
|
31837910 |
2020 |
|
Forgetful
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Transplantation of MSCs carrying CX3CL1 and Wnt3a (CX3CL1-Wnt3a-MSC) significantly attenuated the learning and memory impairment when compared with a control group.
|
31837910 |
2020 |
|
Blepharitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CX3CL1 levels have significantly increased in SM-exposed group with blepharitis, pterygium, and conjunctival pigmentation as compared with the control group.
|
31669888 |
2019 |
|
Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, the high levels of expression of CX3CL1 were positively correlated with glioma patient survival in the TCGA and CGGA databases, and in the clinical samples.
|
30575118 |
2019 |
|
Monoclonal Gammopathy of Undetermined Significance
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that BM CX3CL1 levels were significantly increased in MM patients compared to SMM and MGUS and correlated with BM microvessel density.
|
30845779 |
2019 |
|
Osteoporosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recently conducted studies revealed the participation of CX3CL1 chemokine in the pathogenesis of osteoporosis.
|
31780870 |
2019 |
|
Retinitis Pigmentosa
|
0.010 |
Biomarker
|
disease |
BEFREE |
Soluble CX3CL1 gene therapy improves cone survival and function in mouse models of retinitis pigmentosa.
|
31036641 |
2019 |
|
Chronic pain
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
We analyzed the CCL2 gene rs4586, CALCA rs3781719, CX3CL1 rs614230 single nucleotide polymorphism (SNPs) of 350 Chinese Han women with chronic postsurgical pain (CPSP) 6 months after cesarean section and 350 healthy women without chronic pain (HC).
|
31441843 |
2019 |
|
Conjunctival pigmentation
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
CX3CL1 levels have significantly increased in SM-exposed group with blepharitis, pterygium, and conjunctival pigmentation as compared with the control group.
|
31669888 |
2019 |
|
Inflammatory pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Inhibition of chemokine CX3CL1 in spinal cord mediates the electroacupuncture-induced suppression of inflammatory pain.
|
31564958 |
2019 |
|
Peritoneal Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Detection of its ligand CX3CL1 on the peritoneal mesothelium led us to hypothesize a pathophysiologic role of CX3CL1-CX3CR1 interaction in peritoneal fibrosis.
|
30948201 |
2019 |
|
ovarian neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
The elevated levels of CX3CR1, which were sensitive to CX3CL1, increased EMT markers that led to the progression and metastasis of OvCa.
|
31077234 |
2019 |
|
Ischemic stroke
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In the present study, to investigate whether autophagy could alter CX3CL1 expression on neurons and consequently change microglial inflammatory activity, middle cerebral artery occlusion (MCAO) was established in Sprague-Dawley rats to model ischemic stroke, and tissues from the ischemic penumbra were obtained to evaluate autophagy level and microglial inflammatory activity.
|
30531011 |
2019 |
|
Malignant neoplasm of ovary
|
0.010 |
Biomarker
|
disease |
BEFREE |
The elevated levels of CX3CR1, which were sensitive to CX3CL1, increased EMT markers that led to the progression and metastasis of OvCa.
|
31077234 |
2019 |
|
Major Depressive Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of the study was to explore TNF-α, IL-1β, CXCL12, CCL2, CCL11 (eotaxin-1) and CX3CL1 (fractalkine) as potential biomarkers to identify comorbid MDD and to distinguish primary MDD from substance-induced MDD in patients with substance disorders.
|
30870525 |
2019 |
|
Smoldering myeloma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that BM CX3CL1 levels were significantly increased in MM patients compared to SMM and MGUS and correlated with BM microvessel density.
|
30845779 |
2019 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Theses reviewed in this issue include "Alpha-Synuclein Oligomers: Cellular Mechanisms and Aspects of Antibody Treatment," "Cx3cr1/cx3cl1 Axis Drives the Migration and Maturation of Oligodendroglia in the Central Nervous System," "Genome-Wide Expression Profiling of Human Circulating Monocytes and Macrophages Identifies Diagnostic and Prognostic Signatures for Cancer Outcomes," "Lysosomal Oxidation of Low Density Lipoproteins," and "The Senescence-Associated Secretory Phenotype Induced by ID1-p16 Axis Contributes to Sorafenib Resistance in Hepatocellular Carcinoma."
|
30957657 |
2019 |
|
Adenocarcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Interestingly, survival effects of CX3CL1 were only observed in patients with smoking history and adenocarcinoma (AD, log rank, P = 0.027), but not in patients with squamous cell carcinoma (SQ).
|
29380447 |
2018 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Western blot assay further confirmed the dynamic changes of CX3CL1/CX3CR1 axis in ALS mice.
|
30607245 |
2018 |
|
Arthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Nine genes (MMP3, CCL1, IL17C, CCL20, IL17F, IL3, CXCL5, IL6 and CX3CL1) had concordant expression in SFCs and in peripheral blood cells (PBCs) of PsA compared to PsC and/or controls.
|
29148410 |
2018 |
|
Arthritis, Psoriatic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Nine genes (MMP3, CCL1, IL17C, CCL20, IL17F, IL3, CXCL5, IL6 and CX3CL1) had concordant expression in SFCs and in peripheral blood cells (PBCs) of PsA compared to PsC and/or controls.
|
29148410 |
2018 |
|
Behcet Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The levels of all neutrophil chemoattractants and CXCL10, CXCL16, and CX3CL1 were significantly higher in nongranulomatous uveitis (Behçet's disease and HLA-B27-associated uveitis) than in granulomatous uveitis (sarcoidosis and VKH disease), whereas the levels of the B cell chemoattractant CXCL13 were significantly higher in granulomatous uveitis than in nongranulomatous uveitis.
|
29715366 |
2018 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, based on CX3CL1 immunohistochemistry in non-small cell lung cancer, CX3CL1 levels were positively associated with cancer stage (Pearson chi-square, P = 0.048) and lymph node status (P = 0.033).
|
29380447 |
2018 |