CX3CL1, C-X3-C motif chemokine ligand 1, 6376

N. diseases: 243; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.090 Biomarker disease BEFREE One lgG1, lambda monoclonal antibody (FKN-E12), was derived from synovial B lymphocytes of a patient with sero-negative RA. 10441171 1999
CUI: C0014038
Disease: Encephalitis
Encephalitis
0.010 AlteredExpression disease LHGDN Neuronal fractalkine expression in HIV-1 encephalitis: roles for macrophage recruitment and neuroprotection in the central nervous system. 10640747 2000
CUI: C0019569
Disease: Hirschsprung Disease
Hirschsprung Disease
0.020 Biomarker disease BEFREE Recently, germline mutations of RET, GDNF, and NTN genes have been reported in HSCR. 10946353 2000
CUI: C0085758
Disease: Aganglionosis, Colonic
Aganglionosis, Colonic
0.020 Biomarker disease BEFREE Mutational analysis of RET/GDNF/NTN genes in children with total colonic aganglionosis with small bowel involvement. 10946353 2000
CUI: C0030421
Disease: Paraganglioma
Paraganglioma
0.010 Biomarker disease BEFREE Expression analysis of RET and the GDNF/GFRalpha-1 and NTN/GFRalpha-2 ligand complexes in pheochromocytomas and paragangliomas. 10998441 2000
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma
0.010 Biomarker disease BEFREE Expression analysis of RET and the GDNF/GFRalpha-1 and NTN/GFRalpha-2 ligand complexes in pheochromocytomas and paragangliomas. 10998441 2000
CUI: C4551683
Disease: Adrenal Gland Pheochromocytoma
Adrenal Gland Pheochromocytoma
0.010 Biomarker disease BEFREE Expression analysis of RET and the GDNF/GFRalpha-1 and NTN/GFRalpha-2 ligand complexes in pheochromocytomas and paragangliomas. 10998441 2000
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE Collectively, these results indicate that local injections with OK432 can help the infiltration of adoptively transferred CD8+ T cells into the tumor sites and synergistically induce the local production of the Th1-type cytokines and CXC3 chemokines. 10999462 2000
CUI: C0085758
Disease: Aganglionosis, Colonic
Aganglionosis, Colonic
0.020 GeneticVariation disease BEFREE Relationship between the type of RET/GDNF/NTN or SOX10 gene mutations and long-term results after surgery for total colonic aganglionosis with small bowel involvement. 11685702 2001
CUI: C0162534
Disease: Prion Diseases
Prion Diseases
0.200 Biomarker group RGD Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, during acute and chronic inflammation in the rodent CNS. 11870871 2002
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.040 Biomarker group LHGDN CX(3)C chemokine fractalkine in pulmonary arterial hypertension. 12016106 2002
Chronic mesangial proliferative glomerulonephritis
0.200 Biomarker disease RGD Fractalkine expression and the recruitment of CX3CR1+ cells in the prolonged mesangial proliferative glomerulonephritis. 12028445 2002
CUI: C0006023
Disease: Borna Disease
Borna Disease
0.200 Biomarker disease RGD Upregulation of chemokine receptor gene expression in brains of Borna disease virus (BDV)-infected rats in the absence and presence of inflammation. 12053272 2002
CUI: C0021368
Disease: Inflammation
Inflammation
0.040 Biomarker phenotype LHGDN Fractalkine expression on human renal tubular epithelial cells: potential role in mononuclear cell adhesion. 12100035 2002
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.100 GeneticVariation disease LHGDN Genomic organization and evolution of the CX3CR1/CCR8 chemokine receptor locus. 12551893 2003
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.010 GeneticVariation group LHGDN Genomic organization and evolution of the CX3CR1/CCR8 chemokine receptor locus. 12551893 2003
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.010 AlteredExpression group LHGDN Increased intrathecal release of soluble fractalkine in HIV-infected patients. 12639246 2003
CUI: C0021368
Disease: Inflammation
Inflammation
0.040 AlteredExpression phenotype LHGDN CSF and serum levels of soluble fractalkine (CX3CL1) in inflammatory diseases of the nervous system. 12667665 2003
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.040 Biomarker group BEFREE The chemokine gene cluster [CCL22, CX3CL1, CCL17] (previously known as [SCYA22, SCYD1, SCYA17]) is a candidate locus for one of the susceptibility genes for inflammatory bowel disease that are located in the peri-centromeric region of chromosome 16. 12940913 2003
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.100 Biomarker disease LHGDN Fractalkine in vascular biology: from basic research to clinical disease. 12969992 2004
CUI: C0021368
Disease: Inflammation
Inflammation
0.040 Biomarker phenotype LHGDN Protein overload induces fractalkine upregulation in proximal tubular cells through nuclear factor kappaB- and p38 mitogen-activated protein kinase-dependent pathways. 14514721 2003
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.060 AlteredExpression disease BEFREE Although CX3CL1 expression is upregulated in cultured astrocytes in response to proinflammatory cytokines, no evidence for expression differences of CX3CL1 between control patients and MS patients was found. 14533779 2003
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.060 AlteredExpression disease LHGDN Although CX3CL1 expression is upregulated in cultured astrocytes in response to proinflammatory cytokines, no evidence for expression differences of CX3CL1 between control patients and MS patients was found. 14533779 2003
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.200 Biomarker disease RGD This study investigated the potential of MCs to synthesize CX3CL1/fractalkine, a CX3C chemokine, both in vitro and in acute anti-Thy1 glomerulonephritis in rats. 14605272 2003
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE The effect of CX3CR1 on tumor growth required host cytotoxic effector cell functions because both IFNgamma-/- and perforin-/- mice were resistant to CX3CL1 antitumor effect. 14612547 2003