|
Carcinoma of bladder
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Thus, our results suggest that GSTM1 is involved in the detoxification of 3- and 4-ABP and may contribute to the racial variation in bladder cancer incidence among white, black, and Asian males in Los Angeles, CA.
|
8634658 |
1995 |
|
Carcinogenesis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Our results suggest that steroidal regulation of intracellular SHBG synthesis in the myometrium and the leiomyoma might differ from that in the endometrium, and that the mechanism of SHBG expression in leiomyoma might, in the process of tumorigenesis, be altered from that of corresponding normal myometrium, contributing to SHBG overexpression and the abundant estrogen supply.
|
8629461 |
1995 |
|
ovarian neoplasm
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The expression of SHBG mRNA was detected in all normal ovaries and benign and malignant ovarian tumors analyzed.
|
7581950 |
1995 |
|
Malignant neoplasm of ovary
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Expression of sex hormone-binding globulin mRNA in human ovarian cancers.
|
7581950 |
1995 |
|
Adenocarcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
The higher level of SHBG mRNA tended to be expressed in the normal secretory and late proliferative phase endometrium > early proliferative phase endometrium > well differentiated adenocarcinoma of the endometrium (G1) > moderately differentiated adenocarcinoma (G2) > poorly differentiated adenocarcinoma (G3), in the order shown.
|
7779755 |
1995 |
|
Fibroid Tumor
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that steroidal regulation of intracellular SHBG synthesis in the myometrium and the leiomyoma might differ from that in the endometrium, and that the mechanism of SHBG expression in leiomyoma might, in the process of tumorigenesis, be altered from that of corresponding normal myometrium, contributing to SHBG overexpression and the abundant estrogen supply.
|
8629461 |
1995 |
|
Uterine Fibroids
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Our results suggest that steroidal regulation of intracellular SHBG synthesis in the myometrium and the leiomyoma might differ from that in the endometrium, and that the mechanism of SHBG expression in leiomyoma might, in the process of tumorigenesis, be altered from that of corresponding normal myometrium, contributing to SHBG overexpression and the abundant estrogen supply.
|
8629461 |
1995 |
|
Benign Ovarian Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Relative overexpression of SHBG mRNA was observed in six out of 22 cases (27%) of ovarian cancer (three cases of endometrioid adenocarcinoma, two cases of serous cystadenocarcinoma and one case of mucinous cystadenocarcinoma) in comparison with normal ovaries and benign ovarian tumors.
|
7581950 |
1995 |
|
Carcinoma, Endometrioid
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Relative overexpression of SHBG mRNA was observed in six out of 22 cases (27%) of ovarian cancer (three cases of endometrioid adenocarcinoma, two cases of serous cystadenocarcinoma and one case of mucinous cystadenocarcinoma) in comparison with normal ovaries and benign ovarian tumors.
|
7581950 |
1995 |
|
Cystadenocarcinoma, Mucinous
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Relative overexpression of SHBG mRNA was observed in six out of 22 cases (27%) of ovarian cancer (three cases of endometrioid adenocarcinoma, two cases of serous cystadenocarcinoma and one case of mucinous cystadenocarcinoma) in comparison with normal ovaries and benign ovarian tumors.
|
7581950 |
1995 |
|
Cystadenocarcinoma, Serous
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Relative overexpression of SHBG mRNA was observed in six out of 22 cases (27%) of ovarian cancer (three cases of endometrioid adenocarcinoma, two cases of serous cystadenocarcinoma and one case of mucinous cystadenocarcinoma) in comparison with normal ovaries and benign ovarian tumors.
|
7581950 |
1995 |
|
Endometrial adenocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The higher level of SHBG mRNA tended to be expressed in the normal secretory and late proliferative phase endometrium > early proliferative phase endometrium > well differentiated adenocarcinoma of the endometrium (G1) > moderately differentiated adenocarcinoma (G2) > poorly differentiated adenocarcinoma (G3), in the order shown.
|
7779755 |
1995 |
|
Adenocarcinoma, Endometrioid
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Relative overexpression of SHBG mRNA was observed in six out of 22 cases (27%) of ovarian cancer (three cases of endometrioid adenocarcinoma, two cases of serous cystadenocarcinoma and one case of mucinous cystadenocarcinoma) in comparison with normal ovaries and benign ovarian tumors.
|
7581950 |
1995 |
|
Alcoholic Intoxication, Chronic
|
0.510 |
Biomarker
|
disease |
CTD_human |
Alcoholic hypogonadism: hormonal response to clomiphene.
|
8590623 |
1996 |
|
Alcohol abuse
|
0.310 |
Biomarker
|
disease |
CTD_human |
Alcoholic hypogonadism: hormonal response to clomiphene.
|
8590623 |
1996 |
|
Alcohol Use Disorder
|
0.300 |
Biomarker
|
disease |
CTD_human |
Alcoholic hypogonadism: hormonal response to clomiphene.
|
8590623 |
1996 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
SHBG protein production from the three breast cancer cell lines was detected by immunoprecipitation using an affinity purified SHBG antibody.
|
9010321 |
1996 |
|
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
SHBG protein production from the three breast cancer cell lines was detected by immunoprecipitation using an affinity purified SHBG antibody.
|
9010321 |
1996 |
|
Chronic liver disease
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Comparison of the level of expression of the thyroid hormone-regulated mRNAs encoding T4-binding globulin, sex hormone-binding globulin, cortisol-binding globulin, and transthyretin in normal and diseased tissue revealed no significant difference, suggesting that hepatocellular expression of these mRNAs is maintained in chronic liver disease despite a marked reduction in circulating T3 concentrations.
|
8550778 |
1996 |
|
Endometrial Carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
These results suggest that dedifferentiation of endometrial cancers might induce a reduction in their estrogen-dependent properties via intracellular SHBG.
|
9407970 |
1997 |
|
Endometrial Carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
A decrease of intracellular SHBG caused by high-dose danazol or progesterone might partly contribute to the abolition of the intracellular estrogen-dominant milieu, and be related to the inhibition of estrogen-dependent growth of some endometrial cancer cells.
|
9408086 |
1997 |
|
Malignant neoplasm of endometrium
|
0.060 |
Biomarker
|
disease |
BEFREE |
A decrease of intracellular SHBG caused by high-dose danazol or progesterone might partly contribute to the abolition of the intracellular estrogen-dominant milieu, and be related to the inhibition of estrogen-dependent growth of some endometrial cancer cells.
|
9408086 |
1997 |
|
Androgen-Insensitivity Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
The SHBG decrease was diminished in partial AIS with predominantly female (83.8% +/- 1.7%; range 81.3%-87.0%), ambiguous (80.4% +/- 4.4%, range 68.4%-89.1%), and predominantly male (mean 65.9% +/- 4.9%, range 48.6%-80.8%) phenotypes, and normal in controls (51.4% +/- 2.1%, range 35.6%-62.1%).
|
9007482 |
1997 |
|
Androgen-Insensitivity Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our data suggest that the SHBG changes during the hCG test can be used to assess in vivo the biologic response to androgens in prepubertal patients with ambiguous genitalia, selecting those patients in whom it is worth performing second level investigations to confirm the AIS diagnosis.
|
9029649 |
1997 |
|
Anaplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that dedifferentiation of endometrial cancers might induce a reduction in their estrogen-dependent properties via intracellular SHBG.
|
9407970 |
1997 |