|
Pain, Postoperative
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
HR, SBP, and positive hemodynamic response at peritoneum incision (T<sub>PI</sub>), 5 min (T<sub>AE-5</sub>), 10 min (T<sub>AE-10</sub>), and 15 min (T<sub>AE-15</sub>) after the start of abdominal exploration, and incidences of moderate postoperative pain were recorded.
|
31147972 |
2019 |
|
Seizures
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
ABP-700 produced both involuntary muscle movements (14 of 14 dogs) and seizures (5 of 14 dogs).
|
31166238 |
2019 |
|
Seminoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The LCT group showed higher SHBG (P = 0.018), lower sperm concentration (P = 0.029), and lower motility (P = 0.049) than the seminoma group.
|
31532522 |
2019 |
|
Stress, Psychological
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Male rats subjected to PS displayed slow growth, decreased sperm quality, abnormal levels of the reproductive endocrine hormones, decreased expression of the reproductive-related proteins androgen-binding protein (ABP) and bromodomain-containing protein (BRDT), increased apoptosis in the testis, and accompanied by elevated levels of β-endorphin (β-EP).
|
31623282 |
2019 |
|
Vitamin D Deficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results of meta-analysis showed that, there were no significant differences between the vitamin D deficiency group and the control group on the level of change in systolic pressure (ΔSBP) [weighted mean difference (WMD) = -1.94, 95% confidence interval (CI) (-3.93,0.04) P = .06] and on the level of change in diastolic pressure (ΔDBP) [WMD = -0.50, 95% CI (-1.17, 0.17) P = .14].
|
31083159 |
2019 |
|
Clubbing
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
We therefore measured estrogens, androgens, sex hormone-binding globulin (SHBG), and gonadotropins in five patients with HOA and in 18 patients with simple clubbing.
|
29480386 |
2019 |
|
Myocardial Ischemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
NSTEMI patients without chest pain were significantly older, had lower SBP, more tachycardia, more cerebrovascular disease, but less ischemic heart disease.
|
31759528 |
2019 |
|
Aortic Aneurysm, Abdominal
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Free plasma testosterone levels were lower in the AAA group compared with the HC group (<i>P</i>=0.036), whereas sex hormone-binding globulin levels were higher (<i>P</i>=0.020).
|
31413553 |
2019 |
|
Adult Liver Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A doubling in the concentration of 4-androstenedione was associated with a 50% decreased liver cancer risk (OR=0.50,95%CI=0.30-0.82), while SHBG was associated with a 31% increased risk (OR=1.31,95%CI=1.05-1.63).
|
31808181 |
2019 |
|
Osteopenia/osteoporosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In postmenopausal women with T2DM, higher serum SHBG tended to be associated with lower BMDs, and increased the risk of osteoporosis/osteopenia and the fracture risk.
|
31700893 |
2019 |
|
Osteoarthritis of the hand
|
0.010 |
Biomarker
|
disease |
BEFREE |
We therefore measured estrogens, androgens, sex hormone-binding globulin (SHBG), and gonadotropins in five patients with HOA and in 18 patients with simple clubbing.
|
29480386 |
2019 |
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A doubling in the concentration of 4-androstenedione was associated with a 50% decreased liver cancer risk (OR=0.50,95%CI=0.30-0.82), while SHBG was associated with a 31% increased risk (OR=1.31,95%CI=1.05-1.63).
|
31808181 |
2019 |
|
Premature adrenarche
|
0.010 |
Biomarker
|
disease |
BEFREE |
DHEAS, testosterone, and androstenedione were increased in premature adrenarche, whereas sex hormone binding globulin was decreased in girls with premature adrenarche.
|
30529136 |
2019 |
|
Left atrial dilatation
|
0.010 |
Biomarker
|
disease |
BEFREE |
We analyzed outcome in 4005 treated hypertensive patients (22% obesity, 8% diabetes and 21% current smoking habit) with target attended office SBP less than 140 mmHg, in relation to quintiles of DBP, cardiovascular risk profile and target organ damage (LV hypertrophy, carotid plaque and left atrial dilatation).
|
31205199 |
2019 |
|
Malignant neoplasm of liver
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A doubling in the concentration of 4-androstenedione was associated with a 50% decreased liver cancer risk (OR=0.50,95%CI=0.30-0.82), while SHBG was associated with a 31% increased risk (OR=1.31,95%CI=1.05-1.63).
|
31808181 |
2019 |
|
Intrahepatic Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Seven sex steroid hormones and SHBG were quantitated using gas chromatography-tandem mass spectrometry (GC-MS/MS) and competitive electrochemiluminescence immunoassay, respectively, from baseline serum/plasma samples of 191 post-menopausal female liver cancer cases (HCC n=83, ICC n=56) and 426 controls, matched on sex, cohort, age, race/ethnicity, and blood collection date.
|
31808181 |
2019 |
|
Testicular dysfunction
|
0.010 |
Biomarker
|
disease |
BEFREE |
FSH, LH, and SHBG were higher and the testosterone/LH ratio was lower in LCTs than in the NoL group (P < 0.001).
|
31532522 |
2019 |
|
Hyperactive behavior
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Osmotic-release oral system methylphenidate treatment for 30 days significantly improved ADHD symptoms and abnormal sex hormone levels, normalizing SHBG and bioavailable testosterone percentages that were similar to HCs while free testosterone remained elevated versus HCs.Key pointsCompare to healthy matched controls prepubertal stimulant-naïve boys with ADHD had significantly lower SHBG and higher free and bioavailable testosterone percentages, suggesting a possible effect on sex hormones to ADHD.After 30-day methylphenidate treatment, ADHD symptoms significantly improved, and SHBG and bioavailable testosterone percentages normalized which were similar to HCs, while free testosterone remained elevated versus HCs.We found a negative relationship between MIS levels and hyperactivity scores in ADHD boys.
|
31339400 |
2019 |
|
Chronic active hepatitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Although PWV and cIMT were identical in patients and controls, higher rAI (64.6 ± 1.7 vs. 59.9 ± 1.6%, P = 0.02) and higher central SBP (101.8 ± 1.5 vs. 95.1 ± 1.5 mmHg, P < 0.001) were observed in CAH patients.
|
30036269 |
2019 |
|
Hyperuricemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High levels of BMI, SBP, FPG, TG, LDL-C, ALT, BUN, and creatinine increased the risk of hyperuricemia.
|
31626136 |
2019 |
|
Diabetic peripheral neuropathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ALB = albumin; ALT = alanine transaminase; AST = aspartate transaminase; AUC = area under the curve; AUCc-p/AUCglu = AUC of C-peptide/AUC of glucose; BMI = body mass index; BP = blood pressure; CI = confidence interval; Cr = creatinine; DBP = diastolic blood pressure; DPN = diabetic peripheral neuropathy; FC-P = fasting C-peptide; FPG = fasting plasma glucose; FFA = free fatty acid; γ-GGT = γ-glutamyl transferase; HbA1c = glycated hemoglobin A1c; HDL-C = high-density-lipoprotein cholesterol; ISI = insulin sensitivity index; ISSI-2 = insulin secretion-sensitivity index-2; LDL-C = low-density-lipoprotein cholesterol; MNCS = motor nerve conduction velocity; OGTT = oral glucose tolerance test; PG = plasma glucose; SAT = subcutaneous adipose tissue; SBP = systolic blood pressure; SNCS = sensory nerve conduction velocity; T2DM = type 2 diabetes mellitus; TC = total cholesterol; TG = triglyceride; UA = uric acid; VAT = visceral adipose tissue; WC = waist circumference.
|
30913011 |
2019 |
|
Hypersomnia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Excessive sleep (> 9 hours) compared to 7-9 hours of sleep was significantly associated with lower tT, bT and fT, but not with SHBG or DHEAS.
|
30668526 |
2019 |
|
Metastatic Prostate Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study suggested genetic variation in SHBG (rs6259) might be an independent prognostic biomarker among men treated with primary ADT for metastatic prostate cancer.
|
31036465 |
2019 |
|
Autonomic nervous system disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Conclusions Daytime SD of SBP is a better screening tool than nondipping status in detecting autonomic dysfunction.
|
30905258 |
2019 |
|
Compensatory Hyperinsulinemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Low serum SHBG levels are considered a biomarker of abnormal metabolism and are related to insulin resistance (IR), compensatory hyperinsulinemia and abnormalities in glucose and lipid metabolism in PCOS patients.
|
31525346 |
2019 |