SHBG, sex hormone binding globulin, 6462

N. diseases: 368; N. variants: 20
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.100 Biomarker group BEFREE Hypertension was defined as SBP at least 130 mmHg or DBP at least 80 mmHg, taking antihypertensive medicine or self-report. 31356404 2019
CUI: C3178782
Disease: Aortic Stiffness
Aortic Stiffness 		0.020 Biomarker phenotype BEFREE Aortic stiffness and central SBP are independently associated with orthostatic SBP fall in CKD patients. 31598911 2019
CUI: C0032460
Disease: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome 		0.100 AlteredExpression disease BEFREE Sex hormone-binding globulin levels were lower in women with PCOS and in groups 1 and 3 than those in group N (P < 0.002, P < 0.02, and P < 0.002, respectively) independently of the body mass index. 10566641 1999
CUI: C0022735
Disease: Klinefelter Syndrome
Klinefelter Syndrome 		0.020 Biomarker disease BEFREE ABP profiles were significantly smaller in men with Klinefelter's syndrome who were negative for spermatozoa compared with men who were positive. 11925377 2002
CUI: C0432474
Disease: Klinefelter's syndrome - male with more than two X chromosomes
Klinefelter's syndrome - male with more than two X chromosomes 		0.010 Biomarker disease BEFREE ABP profiles were significantly smaller in men with Klinefelter's syndrome who were negative for spermatozoa compared with men who were positive. 11925377 2002
CUI: C1611743
Disease: Familial (FPAH)
Familial (FPAH) 		0.020 GeneticVariation disease BEFREE Sex hormone-binding globulin polymorphisms in familial and sporadic breast cancer. 12151349 2002
CUI: C1336076
Disease: Sporadic Breast Carcinoma
Sporadic Breast Carcinoma 		0.010 GeneticVariation disease BEFREE Sex hormone-binding globulin polymorphisms in familial and sporadic breast cancer. 12151349 2002
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.100 AlteredExpression phenotype LHGDN Sex hormone binding globulin offers a potential early marker to target women who are at risk for gestational diabetes mellitus. 12861158 2003
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.100 Biomarker disease BEFREE Sex hormone-binding globulin action in estrogen breast cancer cells is strongly associated to cell growth and estrogen-sensitivity. 17447168 2007
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.100 Biomarker disease BEFREE Sex hormone-binding globulin action in estrogen breast cancer cells is strongly associated to cell growth and estrogen-sensitivity. 17447168 2007
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.010 Biomarker disease BEFREE SHBG internalization was specific as it did not occur in either the human neuroblastoma cell line SK-N-SH or the glioma cell line C6. 17684316 2007
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.010 Biomarker disease BEFREE SHBG internalization was specific as it did not occur in either the human neuroblastoma cell line SK-N-SH or the glioma cell line C6. 17684316 2007
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma 		0.010 Biomarker disease BEFREE SHBG internalization was specific as it did not occur in either the human neuroblastoma cell line SK-N-SH or the glioma cell line C6. 17684316 2007
CUI: C0017638
Disease: Glioma
Glioma 		0.010 Biomarker disease BEFREE SHBG internalization was specific as it did not occur in either the human neuroblastoma cell line SK-N-SH or the glioma cell line C6. 17684316 2007
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.050 Biomarker disease BEFREE SHBG alone explained 8% of variance of the CES-D depression score. 23602133 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.040 Biomarker disease BEFREE SHBG alone explained 8% of variance of the CES-D depression score. 23602133 2013
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.040 Biomarker phenotype BEFREE SHBG alone explained 8% of variance of the CES-D depression score. 23602133 2013
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.020 Biomarker disease BEFREE Sex hormone-binding globulin (SHBG), a major controlling factor in the proportion of bioavailable versus bound testosterone and estrogen, has been proposed to contribute to links between hormones and dementia, but has not yet been investigated fully in a prospective biomarker trial. 27767986 2017
CUI: C0497327
Disease: Dementia
Dementia 		0.020 Biomarker disease BEFREE Sex hormone-binding globulin (SHBG), a major controlling factor in the proportion of bioavailable versus bound testosterone and estrogen, has been proposed to contribute to links between hormones and dementia, but has not yet been investigated fully in a prospective biomarker trial. 27767986 2017
CUI: C0001787
Disease: Osteoporosis, Age-Related
Osteoporosis, Age-Related 		0.010 Biomarker disease BEFREE SHBG may play a role in regulating age-related bone loss in men after middle-age. 27873076 2017
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.400 Biomarker disease BEFREE SHBG and TE are independent risk factors for the development of T2D in women. 28223343 2017
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.050 Biomarker group BEFREE Sex Hormone-Binding Globulin Reduction in Metabolic Disorders May Play a Role in NAFLD Development. 28359088 2017
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.030 Biomarker phenotype BEFREE SHBG decreased stepwise with worsening categories of glucose intolerance in females whereas FAI decreased stepwise with worsening categories in males only. 28950181 2017
CUI: C0011847
Disease: Diabetes
Diabetes 		0.100 Biomarker disease BEFREE SBP ≥140 mmHg (OR = 0.78; 95% CI: 0.65-0.95), DBP ≥90 mmHg (OR = 0.71; 95% CI: 0.58-0.88), and a positive family history of diabetes (OR = 0.77; 95% CI: 0.66-0.9) were found as protective factors against zero or five EDP in blood pressure recording the male gender (OR = 1.18; 95% CI: 1.04-1.35) was found to be its independent risk factor. 29137464 2017
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.100 Biomarker group BEFREE SBP ≥140 mmHg (OR = 0.78; 95% CI: 0.65-0.95), DBP ≥90 mmHg (OR = 0.71; 95% CI: 0.58-0.88), and a positive family history of diabetes (OR = 0.77; 95% CI: 0.66-0.9) were found as protective factors against zero or five EDP in blood pressure recording the male gender (OR = 1.18; 95% CI: 1.04-1.35) was found to be its independent risk factor. 29137464 2017