|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We performed a case-control study to compare 5-HTTLPR genotype and allelic frequencies between 43 patients with a DSM-IV diagnosis of BD, with at least one manic/hypomanic episode associated with treatment with proserotonergic antidepressants (AAM+) and 69 unrelated, matched bipolar patients, who had been exposed to proserotonergic antidepressants without development of manic symptoms (AAM-(*)).
|
18534687 |
2009 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Polymorphisms within the DRD1, DRD2, DRD3, DAT1, 5-HTTLPR and HTR2A genes are being studied for association with lithium prophylaxis in a sample of 155 Sardinian unrelated probands affected by bipolar disorder (BP).
|
19647327 |
2009 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests that the markers examined thus far in COMT and SLC6A4 are not associated with pediatric bipolar disorder and that if the val66met marker in BDNF is associated with pediatric bipolar disorder the magnitude of the association is much smaller than first reported.
|
19193231 |
2009 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The findings suggest that the 5-HTTLPR s allele may contribute to a trait-related, genetically derived, neurobiological subgroup within BD characterized by prominent vACC dysfunction.
|
19037205 |
2009 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The aim of this study was firstly to investigate a possible overall impact of the 5-HTTLPR on amygdala volume in patients with bipolar disorder and healthy individuals and secondly to test a diagnosis specific influence of the 5-HTTLPR on amygdala volume.
|
19224115 |
2009 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Is the 5-HTTLPR polymorphism associated with bipolar disorder or with suicidal behavior of bipolar disorder patients?
|
17579356 |
2008 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that BDNF G196A as well as 5HTT-LPR polymorphisms confer risk for SB in BD, but we did not observe any evidence for an interaction between them.
|
18657242 |
2008 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Is the 5-HTTLPR polymorphism associated with bipolar disorder or with suicidal behavior of bipolar disorder patients?
|
17579356 |
2008 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
CTD_human |
The 5-HTTLPR polymorphism could be a useful contributor, among other clinical variables, to predict the risk for manic switches when a patient with bipolar disorder is treated with antidepressant drugs.
|
16395126 |
2006 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Meta-analyses suggest small positive associations between the polymorphism in the serotonin transporter promoter region (5-HTTLPR) and bipolar disorder, suicidal behavior, and depression-related personality traits but not yet to MDD itself.
|
16300747 |
2006 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Antidepressant-induced mania (AIM) has been described in bipolar disorder (BD) and has been associated with the short-allele of the serotonin transporter gene (5-HTT).
|
16945343 |
2006 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results indicate that SLC6A4 might not play a major role in SCZ and BP in Japanese patients, a finding that agrees with both the common disease-common variant hypothesis and common disease-rare variant hypothesis.
|
16082508 |
2006 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Serotonin transporter gene-linked polymorphic region: possible pharmacogenetic implications of rare variants.
|
16829782 |
2006 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The 5-HTTLPR polymorphism could be a useful contributor, among other clinical variables, to predict the risk for manic switches when a patient with bipolar disorder is treated with antidepressant drugs.
|
16395126 |
2006 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The serotonin transporter (5-HTT) is a candidate gene for bipolar disorder (BPD).
|
15824745 |
2005 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The human serotonin transporter gene (5-HTT) is a candidate for the pathogenesis of mood disorders, including bipolar disorder (BPD).
|
16186633 |
2005 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that this new polymorphism in the 5-HTT gene may not influence suicidal behaviour in patients with bipolar disorder.
|
15986189 |
2005 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, the 5-HTTLPR was estimated in 67 patients with bipolar mood disorder, receiving lithium carbonate for prophylactic purposes for the period of more than 5 years (mean 15 years).
|
15849387 |
2005 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
LHGDN |
The serotonin transporter (5-HTT) is a candidate gene for bipolar disorder (BPD).
|
15824745 |
2005 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The 5-HTTLPR polymorphism in the serotonin transporter gene (SLC6A4) may contribute to the risk of bipolar disorder, suicidal behavior, and neuroticism, but association to the lifetime risk of major depression has not been shown.
|
15802092 |
2005 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Current studies have found associations of SLC6A4 polymorphisms with several psychiatric traits including bipolar affective disorder (BPD) in various populations; however, studies with contradictory results were also reported.
|
15167705 |
2004 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Further evidence for a possible association between serotonin transporter gene and lithium prophylaxis in mood disorders.
|
15111989 |
2004 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The overall odds ratio (OR) for the combined individual results was significant for BD and the two 5-HTT polymorphisms: Mantel-Haenszel weighted OR=1.14, CI: 1.03-1.26, P=0.015 for the promoter locus (N=3467) and Mantel-Haenszel Weighted odds ratio OR=1.18, CI: 1.05-1.32, P=0.004 for the VNTR locus (N=3620).
|
12851635 |
2003 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We studied a functional polymorphism of the serotonin transporter (5-HTT) gene (a 44 bp insertion/deletion in the 5-HTT-linked polymorphic region (5-HTTLPR)) and lifetime history of antidepressant-induced mania (AIM) in a population of 305 patients with bipolar affective disorder.
|
12746735 |
2003 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
CTD_human |
Relative to the comparison subjects, subjects with bipolar disorder without panic disorder, but not those with comorbid bipolar disorder and panic disorder, showed significantly higher frequencies of the COMT Met158 and the short 5-HTTLPR alleles and genotypes.
|
11772685 |
2002 |