|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
LKB1 loss exhibited a dramatic reduction on tumor burden and metastatic potential; in particular, OVCAR8-STK11KO tumors had evidence of extensive necrosis, apoptosis and hypoxia.
|
31744879 |
2020 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Detailed phenotyping including tumor IHC and its correlation with comprehensive STK11 genotyping by full gene sequencing followed by large genomic rearrangement analysis was performed in an Indian PJS cohort.
|
30689838 |
2019 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
In this review we discuss exciting recent advances indicating that LKB1 functions as a tumour suppressor perhaps by controlling cell polarity.
|
12829253 |
2003 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
LKB1, the tumour suppressor, is found mutated in Peutz-Jeghers syndrome (PJS).
|
27160967 |
2017 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
All coding exons and exon/intron boundaries of the LKB1 gene were analyzed by direct sequencing in 77 renal cell carcinoma (RCC) tumors and 62 matched noncancerous tissue samples.
|
25179843 |
2014 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Thus, it has been demonstrated recently that the tumor suppressor LKB1 is a kinase that has a major role in phosphorylating and activating AMPK, and that another tumor suppressor, tuberous sclerosis complex 2, is phosphorylated and activated by AMPK.
|
15681023 |
2005 |
|
Neoplasms
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Decreased Expression of Tumor-suppressor Gene LKB1 Correlates with Poor Prognosis in Human Gastric Cancer.
|
26976973 |
2016 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
The LKB1/STK11 serine/threonine kinase is mutated in Peutz-Jeghers' syndrome and acts as a tumour suppressor.
|
11004696 |
2000 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Microtubule affinity-regulating kinases (MARKs; MARK1, MARK2, MARK3 and MARK4) act directly downstream of LKB1, the multitasking tumor-suppressor kinase, and thereby mediate its biological effects.
|
28560405 |
2017 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
More than one of the pathways also appear to contribute to tumor growth following Lkb1 deficiencies based on a number of mouse tumor models.
|
21926085 |
2011 |
|
Neoplasms
|
0.200 |
AlteredExpression
|
group |
BEFREE |
LKB1 protein expression was evaluated using immunohistochemistry in tumors from early breast cancer patients in two Taiwanese medical centers.
|
26877155 |
2016 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
None of STK11 mutated tumors (n = 7) expressed PD-L1.
|
30885341 |
2019 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
To investigate whether genetic alteration of the STK11 (serine/threonine kinase 11)/LKB1 tumor-suppressor gene is involved in the carcinogenesis of head and neck squamous cell carcinoma (HNSCC), the entire encoding exons and flanking intronic sequences of the STK11/LKB1 gene were analysed with direct genomic sequencing of 15 HNSCC specimens.
|
16407837 |
2006 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Liver kinase B1 (LKB1) is a tumor suppressor, and there is a very high proportion of LKB1 mutation in lung adenocarcinoma.
|
30185829 |
2018 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
LKB1 functions as a tumor suppressor in sporadic cancers including lung cancer.
|
29138862 |
2018 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
LKB1 (also known as serine-threonine kinase 11, STK11) is a tumor suppressor, which is mutated or deleted in Peutz-Jeghers syndrome (PJS) and in a variety of cancers.
|
24387336 |
2014 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
The data suggest that LKB1 functions as a tumor suppressor by not only inhibiting proliferation, but also by exerting profound effects on cell polarity and, most unexpectedly, on the ability of a cell to detect and respond to low cellular energy levels.
|
16756488 |
2006 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
If the STK11 gene is one of the mutational targets of microsatellite instability, its inactivation may be associated with tumor development in a small proportion of colorectal cancers.
|
10429655 |
1999 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
The kinase LKB1 is a critical tumor suppressor in sporadic and familial human cancers, yet the mechanisms by which it suppresses tumor growth remain poorly understood.
|
31350327 |
2019 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Liver kinase B1 (LKB1) is a newly discovered tumor suppressor gene that plays a role in apoptosis induction.
|
30863111 |
2019 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Since PJS patients also show a predisposition to a wide spectrum of cancers, it is speculated that LKB1 has a tumor suppressor function.
|
10441497 |
1999 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Here, we summarize the current knowledge about the upstream regulation of LKB1, which is important for the understanding of the pathogenesis of many types of tumors.
|
29540834 |
2018 |
|
Neoplasms
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Similar tumor and redox heterogeneity also exist in human NSCLC with LKB1 inactivation.
|
25936644 |
2015 |
|
Neoplasms
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Patients with LKB1 expression loss experienced significantly lower disease-free survival (DFS) (hazard ratio [HR], 1.287; 95% confidence interval [CI], 1.093 to 1.654; p=0.021) and overall survival (OS) (HR, 1.541; 95% CI, 1.197 to 1.932; p=0.002), compared to patients with LKB1 expressing expressing tumors.
|
30913862 |
2019 |
|
Neoplasms
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Loss of LKB1 activity is prevalent in <i>KRAS</i> mutant lung adenocarcinoma and promotes aggressive and treatment-resistant tumors.
|
28289710 |
2017 |