|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
This results indicate that STK11 is a tumor suppressor gene and that genetic changes of STK11 play an important role in left-sided colon cancer carcinogenesis.
|
9731485 |
1998 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Haplotype analysis indicated that the retained allele carried a germ-line mutation, confirming that STK11 is a tumor suppressor gene.
|
9850045 |
1998 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
This observation and a previous observation that the LKB1 locus is often deleted in PJS polyps suggest that the gene may function as a tumor suppressor.
|
9605748 |
1998 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Germ-line mutations of the gene have been detected in familial PJS patients and are predicted to predispose STK11 carriers to the development of a wide range of gastrointestinal and other neoplasms.
|
9683800 |
1998 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
If the STK11 gene is one of the mutational targets of microsatellite instability, its inactivation may be associated with tumor development in a small proportion of colorectal cancers.
|
10429655 |
1999 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Since PJS patients also show a predisposition to a wide spectrum of cancers, it is speculated that LKB1 has a tumor suppressor function.
|
10441497 |
1999 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Germline mutations in LKB1 have been reported to underlie familial Peutz-Jeghers syndrome (PJS) with intestinal hamartomatous polyps and an elevated risk of various neoplasms.
|
9887330 |
1999 |
|
Neoplasms
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Here, we have identified tumor cell lines with severely reduced mRNA levels and impaired Lkb1 kinase activity.
|
10430928 |
1999 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
To evaluate whether somatic mutations of LKB1 contribute to the tumorigenesis of yet unstudied tumor types, we screened 14 cell lines and 129 tumor specimens from different cancers for a genetic defect in LKB1.
|
10079245 |
1999 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Allelic imbalance [allele loss, loss of heterozygosity (LOH)] has previously been reported in a small number of PJS polyps, suggesting that LKB1 acts as a tumour suppressor in these tumours.
|
10398133 |
1999 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Two LKB1/STK11 mutations were found: a missense change (Y49D) accompanied by allele loss in a cell line; and a missense change (G135R), without a detected mutation in the other allele, in a primary tumor.
|
10201537 |
1999 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
LKB1 is therefore a candidate tumour suppressor gene for sporadic ovarian tumours.
|
10389980 |
1999 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
The LKB1/STK11 serine/threonine kinase is mutated in Peutz-Jeghers' syndrome and acts as a tumour suppressor.
|
11004696 |
2000 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Germ-line mutations of the LKB1 gene cause Peutz-Jeghers syndrome (PJS) characterized by mucocutaneous pigmentation, predisposition to benign hamartomas of the gastrointestinal tract and also to several types of tumors.
|
10644993 |
2000 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo.
|
10642527 |
2000 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
The recently cloned STK11/LKB1 on chromosome 19p has been shown to be a new tumor suppressor gene.
|
10852375 |
2000 |
|
Neoplasms
|
0.200 |
PosttranslationalModification
|
group |
BEFREE |
To investigate the LKB1/STK11 gene for promoter hypermethylation and allelic loss in tumour specimens of patients with sporadic colorectal cancer.
|
10896921 |
2000 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
The causative gene is a protein kinase termed LKB1, predicted to function as a tumor suppressor.
|
11297520 |
2001 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
PJS patients with no identified STK11/LKB1 mutation are at major risk for proximal biliary adenocarcinoma, an infrequent tumour in the general population.
|
11389158 |
2001 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
These results provide further evidence that STK11/LKB1 acts as a tumour suppressor gene, and may be involved in the early stages of PJS tumorigenesis.
|
11215281 |
2001 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
The causative gene encodes a nuclear-localized protein kinase, termed LKB1, which is predicted to function as a tumour suppressor.
|
11853558 |
2002 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
In nearly 50% of patients PJS is caused by germ line mutations in the STK11/LKB1 serine/threonine kinase gene, the only kinase gene currently known to act as a tumor suppressor.
|
12112668 |
2002 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Moreover, the tumor showed loss of heterozygosity of the 19p marker near STK11 and somatic mutation of the p53 gene.
|
12051537 |
2002 |
|
Neoplasms
|
0.200 |
PosttranslationalModification
|
group |
BEFREE |
The epigenetic features analyzed were the 5-methylcytosine content in the genome of the tumors and their normal counterparts, and the presence of CpG island hypermethylation of tumor suppressor genes (p16(INK4a), p14(ARF), hMLH1, MGMT, APC, LKB1, DAPK, GSTP1, BRCA1, RAR beta 2, CDH1, and RASSF1).Two positive associations were found.
|
12154064 |
2002 |
|
Neoplasms
|
0.200 |
AlteredExpression
|
group |
BEFREE |
We also demonstrated that low LKB1 protein expression correlates with higher histological grade (P = 0.013), larger tumor size (P = 0.001), progesterone receptor status (P = 0.048), and presence of lymph node metastasis (P = 0.003).
|
12114407 |
2002 |