|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Tumours were obtained from patients of US (n=143) and Korean (n=167) origin and screened for LKB1, KRAS, BRAF, and EGFR mutations using RT-PCR-based SURVEYOR-WAVE method followed by Sanger sequencing.
|
18594528 |
2008 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Tumor Suppressor LKB1 inhibits both the mRNA Expression and the Amplification of hTERC by the Phosphorylation of YAP in Lung Cancer Cells.
|
31333780 |
2019 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
LKB1 is therefore a candidate tumour suppressor gene for sporadic ovarian tumours.
|
10389980 |
1999 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo.
|
10642527 |
2000 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
LKB1, the product of a tumour suppressor gene, is a serine/threonine kinase that coordinates disparate cellular processes.
|
15186763 |
2004 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Lkb1-deficient tumours demonstrated shorter latency, an expanded histological spectrum (adeno-, squamous and large-cell carcinoma) and more frequent metastasis compared to tumours lacking p53 or Ink4a/Arf.
|
17676035 |
2007 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
LKB1 plays the role of tumor suppressor, opposite to Akt, by negatively regulating mammalian target of rapamycin through the activation of AMP-activated protein kinase and TSC signaling.
|
18794113 |
2008 |
|
Neoplasms
|
0.200 |
AlteredExpression
|
group |
BEFREE |
LKB1 directly activates a family of 14 kinases related to AMPK [adenosine monophosphate (AMP)-activated protein kinase] to control cell metabolism, growth, and polarity, though which of these are critical to its tumor suppressor functions remain undefined.
|
19724060 |
2009 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
LKB1, originally considered a tumor suppressor, plays an important role in hepatocyte proliferation and liver regeneration.
|
20815019 |
2010 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
LKB1 can regulate a host of different functions which all have potential to impact upon the initiation and progression of neoplastic disease.
|
21241696 |
2011 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Liver kinase B1 (LKB1), as a serine/threonine kinase and tumor suppressor, is frequently mutated and inactivated in non-small cell lung cancer (NSCLC).
|
21380642 |
2011 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
LKB1 (also known as serine-threonine kinase 11, STK11) is a tumor suppressor, which is mutated or deleted in Peutz-Jeghers syndrome (PJS) and in a variety of cancers.
|
24387336 |
2014 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
LKB1 and FUS1 are two kinds of new tumor suppressor genes as well as early-stage genes in lung cancer.
|
24659339 |
2014 |
|
Neoplasms
|
0.200 |
AlteredExpression
|
group |
BEFREE |
LKB1 Loss induces characteristic patterns of gene expression in human tumors associated with NRF2 activation and attenuation of PI3K-AKT.
|
24828662 |
2014 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Liver kinase B1 (LKB1) is a serine/threonine kinase that functions as a tumor suppressor and regulates cell polarity, proliferation, and metabolism.
|
25042259 |
2014 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
LKB1 loss did not correlate with a specific KRAS mutation but was more frequent in tumors with KRAS transversion mutations (P = 0.029).
|
25737507 |
2015 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Liver kinase B1 (LKB1) is a tumor suppressor ubiquitously expressed serine/threonine protein kinase involved in energy metabolism and cellular polarity.
|
25798842 |
2016 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Liver kinase B1 (LKB1), also known as serine/threo-nine kinase 11 (STK11), is a tumor suppressor that is inactivated in Peutz-Jeghers familial cancer syndrome.
|
26398719 |
2015 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
LKB1 protein is a tumor‑suppressor in gastric cancer and may be potentially be developed as a novel gene therapy target in the treatment of gastric cancer.
|
26549522 |
2016 |
|
Neoplasms
|
0.200 |
AlteredExpression
|
group |
BEFREE |
LKB1 protein expression was evaluated using immunohistochemistry in tumors from early breast cancer patients in two Taiwanese medical centers.
|
26877155 |
2016 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Serine/threonine kinase 11 gene (STK11), better known as liver kinase β1, is a tumor suppressor that is commonly mutated in lung adenocarcinoma (LUAD).
|
26917230 |
2016 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
LKB1, the tumour suppressor, is found mutated in Peutz-Jeghers syndrome (PJS).
|
27160967 |
2017 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
LKB1 is a commonly mutated tumor suppressor in non-small cell lung cancer that exerts complex effects on signal transduction and transcriptional regulation.
|
27821489 |
2017 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
LKB1 as a Tumor Suppressor in Uterine Cancer: Mouse Models and Translational Studies.
|
27910069 |
2017 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Liver kinase B1 ( LKB1 ) is a tumor suppressor in lung adenocarcinoma (LADC).
|
28376202 |
2017 |