|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Therefore, we here developed a mouse model of asthma by microinjecting the pronucleus with a vector spontaneously coding human IL10 and TGFB1 gene to explore the possible interaction between these two potent molecules during asthma progression.
|
27696149 |
2016 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Therefore, TGFbeta1 is a promising candidate gene for contributing to asthma severity.
|
11810274 |
2001 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The three cytokine genes involved are interleukin (IL)-4, IL-9 and transforming growth factor beta1, and the nature of the polymorphisms may be related to significantly higher outputs of these cytokines in atopy and asthma.
|
10224407 |
1999 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
The results showed that RAGE inhibition or RAGE knockdown decreased β-catenin nuclear accumulation and the expression of relevant β-catenin targeted genes (VEGF, MMP9, TGF-β1) in the TDI-induced murine asthma model and TDI-HSA-treated 16HBE cells, respectively.
|
29656209 |
2018 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The present study investigated two polymorphisms within the gene coding for TGF-beta1, -C509T and G915C, and for their potential association with bronchial asthma in Caucasian children.
|
15943594 |
2005 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
RGD |
The levels of TGF-beta1 mRNA and collagen type III in cigarette smoke treated group (0.42 +/- 0.04, 25.8 +/- 2.3) were higher than those in the asthmatic group (0.39 +/- 0.04, 22.9 +/- 3.1) and in the control group (0.26 +/- 0.04, 16.3 +/- 2.3).
|
18366906 |
2008 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The goal of this study was to investigate a gene-gene interaction between IL-10 and TGF-beta1 polymorphisms in Korean asthmatics with aspirin hypersensitivity.
|
19222424 |
2009 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The functional TGFβ1 promoter SNP C-509 associates with renal fibrosis and asthma.
|
26656423 |
2015 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The frequencies of the genotype associated with low production of TGF-beta1 were 14% versus 1% in infants with and without a parental history of asthma, respectively (p < 0.01).
|
15120189 |
2004 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
The exhaled-TGF-β1 levels were significantly lower in those children with asthma exacerbation when compared to the stable asthmatic children (<i>p</i> = 0.0003).<b>Conclusion:</b> Our results suggest that TGF-β1 may play a role in suppressing airway reactivity and its deficiency is associated with asthma exacerbation.AbbreviationsACTAsthma control testAHRAirway hyper-reactivityASMAirway smooth muscleBALBronchoalveolar lavageELISAEnzyme-linked immunoassayEIBExercise-induced bronchospasmEBCExhaled breath condensateFEV1Forced expiratory volume in the first secondFEV1/FVCForced expiratory volume in the first second/forced vital capacityFEF25%-75%Forced expiratory flow, midexpiratory phaseGINAGlobal Initiative for Asthma(Ig)EImmunoglobulin EISAACInternational Study of Asthma and Allergies in ChildhoodIQRInterquartile rangeIL-10Interleukin-10TGF-β1Transforming growth factor-β1Treg cellsT regulatory cells.
|
31709879 |
2019 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The carriers of both IL4-RA Q551R A/G and TGF-beta1 C-509T C/T did not have a more significant risk of having asthma than those who covered either.
|
19657898 |
2009 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to analyze common TGFB1 gene promoter polymorphisms C-509T and G-800A in Serbian asthmatics and to investigate their association with exacerbations.
|
27627560 |
2016 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study is to evaluate plasma TGF-beta 1 level in stable asthmatic sufferers and to investigate its correlation with the asthma control test.
|
19331718 |
2009 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of this meta-analysis was to evaluate the relation of two transforming growth factor-β1 (TGF-β1) polymorphisms with asthma risk in Chinese population.
|
29958018 |
2018 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The aim of the present study was to identify polymorphic forms of the nuclear receptor subfamily 3, group C, member 1 (NR3C1) and transforming growth factor β1 (TGF-β1) genes and evaluate their impact on the expression levels of interleukin (IL)-5 and IL‑15 in asthma.
|
27081784 |
2016 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The aim of the present study was to evaluate the effect of TGF-β1 mRNA expression on IL-15 mRNA expression in asthmatic patients and to assess the role of IL-15 in the clinical course of asthma.
|
29104662 |
2017 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The transforming growth factor β1 (TGFB1) polymorphism -509C>T also modified the association of pollutants with asthma.
|
24243740 |
2014 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The TGFbeta1-509C>T polymorphism was not significantly associated with the AIA phenotype; however, a significant association with the prevalence of rhinosinusitis in AIA (P=0.012), but not in ATA (P>0.05), was observed.
|
16916603 |
2007 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
TGF-beta(2) expression was observed in both the normal and asthmatic bronchial epithelium, and both real-time PCR and an ELISA showed a significant basal and TGF-beta(1)-induced TGF-beta(2) expression in the bronchial epithelial cell line BEAS2B.
|
17651146 |
2007 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these results demonstrate that SIRT7 is involved in regulating TGF-β1-induced ASM cell proliferation and migration by regulating the expression of TβRI, thus indicating an important role of SIRT7 during airway remodeling in asthma.
|
29843083 |
2018 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Taken together, the present results have revealed that PCA inhibits asthma airway remodeling by suppressing proliferation and extracellular matrix (ECM) protein deposition in TGF-β1-mediated ASMCs via the inactivation of Smad2/3 signaling pathway.
|
30472056 |
2019 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Subjects with more severe asthma had higher serum levels of TGF-β1 and TNF-α.
|
23466425 |
2013 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Some studies have indicated that transforming growth factor beta(1) (TGF-beta(1)), a pleiotropic cytokine regulating inflammatory reactions and airway remodeling, may participate in the pathogenesis of asthma.
|
19136038 |
2009 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
SNPs in TGFB1 are associated with airway responsiveness and disease exacerbations in children with asthma.
|
19096005 |
2009 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Rhinovirus replication and virus release into supernatants were enhanced in fibroblasts incubated with TGF-beta1 and in fibroblasts obtained from patients with asthma.
|
19168696 |
2009 |