|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Effect of TLR4/MyD88 signaling pathway on sepsis-associated acute respiratory distress syndrome in rats, via regulation of macrophage activation and inflammatory response.
|
29545858 |
2018 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To simulate sepsis, male C57BL/6 (wild-type) and C57BL/10ScNJNJU (TLR4<sup>-/-</sup>) mice were subjected to cecal ligation and puncture (CLP).
|
29149705 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, the present results suggested that apelin had a protective effect against sepsis‑induced cardiac impairment by attenuating TLR4 and NLRP3 signaling‑mediated inflammatory responses.
|
29749463 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
TLR4 recognizes lipopolysaccharide (LPS) and drives the secretion of inflammatory cytokines, often contributing to sepsis.
|
29343440 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Circulating histones contribute to inflammation, and to lethality in sepsis, a hyperinflammatory condition, by interacting with specific receptors, notably toll-like receptor 4 (TLR4).
|
29997623 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Monophosphoryl lipid A (MPLA) is a detoxified TLR4 agonist that enhances innate antimicrobial immunity and improves survival following sepsis.
|
29741098 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Toll-like receptor 4 (TLR4)-a transmembrane pattern-recognition receptor responsible for propagating the immediate immune response to Gram-negative bacterial infection-plays a central role in the pathogenesis of sepsis and chronic inflammation-related disorders.
|
30276970 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings indicate that CIRP is a proinflammatory mediator that plays an important role in T-cell dysregulation during sepsis in a TLR4-dependent manner.
|
27569563 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the present study, the role of deleted in liver cancer 1 (DILC), interleukin (IL)‑6, signal transducer and activator of transcription 3 (STAT3), and Toll‑like receptor 4 (TLR4) in the pathogenesis of sepsis was investigated.
|
30365067 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, GLN has a potential therapeutic effect in the protection against cardiac dysfunction mediated by sepsis through regulating the TLR4/MAPK/NF-κB signaling pathway.
|
29285127 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
ULI administration may improve patient outcome by reducing the spinal inflammation through a mechanism involving the TLR4/MyD88/NF-κB signaling in sepsis.
|
28796387 |
2017 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, preemptive clinical sedative doses of DXM may upregulate the expression of caveolin‑1 downregulated by sepsis, which may contribute to the inhibition of inflammatory pathways such as TLR4‑mediated pathways.
|
28000867 |
2017 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expressions of TLR4 and NF-κB p65 protein were significantly lower in simvastatin-treated rats than that in sepsis rats at the same time point.
|
28800541 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Activation of the TLR4 receptor by bacterial lipopolysaccharide (LPS) is the most widely studied TLR pathway due to its central role in host responses to gram-negative bacterial infection and its contribution to endotoxemia and sepsis.
|
28248925 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, the identification of platelet TF and TLR4 as regulators of the effect of E. coli O111 might represent a novel therapeutic target to reduce the devastating consequences of the hemostatic disorder during sepsis.
|
28957360 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The virulence properties demonstrated by Acinetobacter spp. primarily stem from evasion of rapid clearance by the innate immune system, effectively enabling high bacterial density that triggers lipopolysaccharide (LPS)-Toll-like receptor 4 (TLR4)-mediated sepsis.
|
27974412 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Because TcpB suppresses both TLR4- and caspase-4/11-mediated inflammation, TcpB might be a candidate target for developing drugs against LPS-induced septicemia.
|
29061850 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Myeloid differentiation 2 (MD2) is essential to the recognition of lipopolysaccharide (LPS) and the subsequent mediation of toll-like receptor 4 (TLR4)-dependent acute inflammatory disorders including sepsis and acute lung injury.
|
28858767 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Activation of the TLR4 receptor by bacterial lipopolysaccharide (LPS) is the most widely studied TLR pathway due to its central role in host responses to gram-negative bacterial infection and its contribution to endotoxemia and sepsis.
|
28248930 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aim of the present work was to delineate the beneficial role of BZL during sepsis, analyzing its effects on the cellular redox status and the possible link to the innate immunity receptor TLR4.
|
27899278 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recent studies found toll-like receptors 4 (TLR4) played an important role in sepsis.
|
28056977 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Targeting myeloid differentiation protein 2 (MD-2) or Toll-like receptor 4 (TLR4) with small molecule inhibitor rescues the systemic inflammatory response syndrome (SIRS) in sepsis due to infection with Gram-negative bacteria but not other microbes.
|
28145460 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, early-onset sepsis in term babies is caused by gram-positive species in more than 90% of cases, and neuro-inflammatory responses triggered through the gram-negative route (Toll-like receptor 4, TLR-4) are different from those induced through the gram-positive route via TLR-2.
|
28407632 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Acute hepatic dysfunction associating sepsis is mediated mainly by toll-like receptor-4 (TLR-4)/nuclear factor kappa-B (NF-κB) inflammatory pathway.
|
28189063 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to assess the role played by TLR4 and by the NLRP3 inflammasome in the cardiac dysfunction that occurs after high-grade polymicrobial sepsis.
|
29176403 |
2017 |