|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, only passive coping rats exhibited increased proinflammatory proteins (IL-1β, TNF-α, GM-CSF) in the locus coeruleus (LC), a noradrenergic brain region implicated in depression.
|
27592314 |
2017 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Because several polymorphisms in the TNF-α promoter region are known to affect its gene expression, the aim of this study was determine whether TNF-α - 857C/T, -308G/A, and -238G/A polymorphisms confer susceptibility to depression during pregnancy in a Mexican mestizo population.
|
29424322 |
2018 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Markers exhibiting the most consistent associations with depression include tumour necrosis factor-α, flow-mediated dilation, endothelin-1, endothelial progenitor cells, brain-derived neurotrophic factor, and docosahexaenoic acid.
|
26812919 |
2016 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Findings across the literature suggest that functional allelic variants of genes for interleukin-1beta (IL)-1β, tumor necrosis factor-alpha (TNF-α) and C-reactive protein (CRP), as well as genetic variations affecting T-cell function, may increase the risk for depression.
|
22580182 |
2013 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Since depression is a common co-morbid condition with PD, we undertook this study to determine whether Hc-TeTx might also show antidepressant-like properties and whether central brain-derived neurotrophic factor (BDNF) and/or tumor necrosis factor (TNF)-alpha are also affected by it.
|
31125623 |
2019 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Considering the inflammatory-depression link, and that women are twice as likely to experience depression compared to men, the current study (<i>N</i> = 475 university students) examined the moderating role of three independent cytokine single nucleotide polymorphisms (SNPs; IL-1β rs16944, IL-6 rs1800795 SNP, TNF-α rs1800629) in the relationship between early-life adversity and depressive symptoms, and whether these relations differed between males and females.
|
30967802 |
2019 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
-308(G/A) TNF-alpha gene polymorphism and risk of depression late in the life.
|
19836613 |
2009 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis revealed that TNF-α G-308A polymorphism is not associated with susceptibility to depression.
|
29118582 |
2017 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The TNF-alpha A allele was associated with worsened labile anger (F = 2.5; P < 0.05) and fatigue (F = 2.9; P < 0.05) during treatment but not with major depression incidence (chi = 0.0; P = 0.99) or increased Beck Depression Inventory II (F = 1.2; P = 0.31).
|
20661026 |
2010 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In inflammatory cytokines, increased cytokines [including interleukin (IL) 1beta, IL-18, tumor necrosis factor alpha] after stroke lead to depression.
|
19891854 |
2009 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To gain rich and valid information at the symptom level, this article developed a depression test under the framework of cognitive diagnosis models (CDMs), referred to as CDMs-D. A total of 1,181 individuals were finally recruited and their responses were used to examine the psychometric properties of CDMs-D. After excluding poor items for statistical reasons (e.g., low discrimination, poor model-fit or having DIF), 56 items were included in the CDMs-D.
|
31214095 |
2019 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It is concluded that the association of <i>TNF-RII</i> rs1061622 with depression is longitudinally different in Chinese Han adolescents after the 2008 Wenchuan earthquake.
|
29799484 |
2018 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
We have assessed TNF(-/-), TNF-R1(-/-) and TNF-R2(-/-) mice against C57BL/6 wild-type (WT) mice from 12 weeks of age in order to evaluate measures of spatial memory and learning in the Barnes maze (BM) and Y-maze, as well as other behaviours such as exploration, social interaction, anxiety and depression-like behaviour in a battery of tests.
|
24094876 |
2013 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
We demonstrated that prenatal stress leads to depression-like behavior, decreased IGF-1, increased IL-1β, TNF-α and IFN-γ release and disturbed SOCS-1, SOCS-2 and SOCS-3 expression in the hippocampus and frontal cortex of adult offspring.
|
25151093 |
2014 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our studies demonstrated that CGA pretreatment ameliorated depression-like behavior (SPT, FST, TST, and OFT) and serum biochemical levels (5-HT, DA, IL-6, and TNF-α) in ACTH-induced depression rats.
|
31073553 |
2019 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest that TNFα plays a critical role in mediating UCMS-induced depression through up-regulation of IDO and subsequent damage of cortical neurons.
|
26083579 |
2016 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Stress-related suppression of TNFα predicted drinking severity only in alcohol-dependent individuals with subclinical depression, and suppressed TNFR1 following stress was only seen in individuals with subclinical depression.
|
31736187 |
2019 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The goal of this study was to investigate the effects of etanercept (ETN), an anti-tumor necrosis factor α (TNF-α) protein, on cavernosal function in the unpredictable chronic mild stress (UCMS) rat model of depression.
|
30052465 |
2018 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Compelling evidence supports the involvement of the pro-inflammatory cytokines, IL-6, IFN-α and TNF-α in depression and related stress-associated pathologies.
|
27876634 |
2017 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The 10th revision of the International Statistical Classification of Diseases and Related Health Problems was utilized to diagnose depression and PTSD.At 7a.m. blood samples were collected and serum NT-4/5, GPX-1, TNF-α and l-arginine concentrations were assessed using the ELISA method.
|
28958613 |
2017 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, levels of serum CRP, IL-6, TNF-α and BDNF can be used as judgment indicators for the severity of depression.
|
29849779 |
2018 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we tested the leukocyte mRNA expression levels of genes belonging to glucocorticoid receptor (GR) function (FKBP-4, FKBP-5, and GR), inflammation (interleukin (IL)-1α, IL-1β, IL-4, IL-6, IL-7, IL-8, IL-10, macrophage inhibiting factor (MIF), and tumor necrosis factor (TNF)-α), and neuroplasticity (brain-derived neurotrophic factor (BDNF), p11 and VGF), in healthy controls (n=34) and depressed patients (n=74), before and after 8 weeks of treatment with escitalopram or nortriptyline, as part of the Genome-based Therapeutic Drugs for Depression study.
|
22990943 |
2013 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
TNF-α was not associated with depression severity.
|
30035700 |
2018 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
To investigate increased gut permeability (a "leaky gut") as one potential mechanistic pathway from marital distress and depression to heightened inflammation, this secondary analysis of a double-blind, randomized crossover study examined serial assessments of two endotoxin biomarkers, LPS-binding protein (LBP) and soluble CD14 (sCD14), as well as C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) during two separate 9.5 h visits.
|
30098513 |
2018 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
To further elucidate inflammatory mechanisms related to TNF in depression, the aim of the current study was to investigate the involvement of ligands and receptors of the TNF/TNF-receptor-superfamily yet un- or little explored in major depression.
|
31622870 |
2019 |