|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
-308(G/A) TNF-alpha gene polymorphism and risk of depression late in the life.
|
19836613 |
2009 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
1 L-1β, TNF-α and COX-2), increased BDNF expression and neurogenesis, restored the dysfunction of ATP production and oxidative stress in inflammation- induced depression.
|
31022424 |
2019 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Depression after myocardial infarction: TNF-α-induced alterations of the blood-brain barrier and its putative therapeutic implications.
|
23415700 |
2013 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Depression was directly related to evening salivary cortisol and inflammation, such that higher evening cortisol predicted greater depressive symptoms (β=0.215, p<0.01) and higher pro-inflammatory cytokines (interleukin-2 [IL-2], IL-6, and tumor necrosis factor-alpha [TNF-α] levels (β=0.185, p<0.05), when controlling for covariates.
|
28918107 |
2018 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Depression and TNF may have a two-way relationship.
|
29460011 |
2018 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
TNF-α -308G/A and IL-8 -251T/A were significantly associated with AD and IL-1β +3953C/T with late-life depression, while the significance of these associations was lost after Bonferroni correction.
|
25315113 |
2015 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
TNF was not a moderator of the effects of either interpersonal or non-interpersonal stress on later depression outcomes.
|
25596176 |
2015 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
TNF-α was not associated with depression severity.
|
30035700 |
2018 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
A significant number of protein targets such as IL10, MAPK1, PTGS2, AKT1, APOE, PPARA, MAPK1, MIF, NOS3 and TNF-α were found to be involved in the functioning of Tiansi Liquid against depression.
|
28954415 |
2017 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
According to the current literature, it seems that peripheral levels of interleukin (IL)-6, IL-10, IL-12, IL-13, and tumor necrosis factor (TNF)-α are elevated and that interferon (IFN)-γ levels are lower in patients with depression compared to healthy controls.
|
30792669 |
2019 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Altered expression of norepinephrine transporter participate in hypertension and depression through regulated TNF-α and IL-6.
|
30957546 |
2020 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Among people with only a drug use disorder, TNF-α was positively associated with depression score.
|
29500107 |
2018 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
BDNF levels were negatively correlated and IL-1β and TNF-α levels were positively correlated with Hamilton Depression Rating Scale-24 scores.
|
30616482 |
2019 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Because several polymorphisms in the TNF-α promoter region are known to affect its gene expression, the aim of this study was determine whether TNF-α - 857C/T, -308G/A, and -238G/A polymorphisms confer susceptibility to depression during pregnancy in a Mexican mestizo population.
|
29424322 |
2018 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Compelling evidence supports the involvement of the pro-inflammatory cytokines, IL-6, IFN-α and TNF-α in depression and related stress-associated pathologies.
|
27876634 |
2017 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Considering the inflammatory-depression link, and that women are twice as likely to experience depression compared to men, the current study (<i>N</i> = 475 university students) examined the moderating role of three independent cytokine single nucleotide polymorphisms (SNPs; IL-1β rs16944, IL-6 rs1800795 SNP, TNF-α rs1800629) in the relationship between early-life adversity and depressive symptoms, and whether these relations differed between males and females.
|
30967802 |
2019 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Correlation analysis revealed that depression severity negatively correlated with IL-12 in males, and positively correlated with IL-1β and tumor necrosis factor (TNF)-α in females.
|
28670290 |
2017 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of tumor necrosis factor-alpha and interferon-gamma mRNA in blood cells correlates with depression scores during an acute attack in patients with multiple sclerosis.
|
12084660 |
2002 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Findings across the literature suggest that functional allelic variants of genes for interleukin-1beta (IL)-1β, tumor necrosis factor-alpha (TNF-α) and C-reactive protein (CRP), as well as genetic variations affecting T-cell function, may increase the risk for depression.
|
22580182 |
2013 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, only passive coping rats exhibited increased proinflammatory proteins (IL-1β, TNF-α, GM-CSF) in the locus coeruleus (LC), a noradrenergic brain region implicated in depression.
|
27592314 |
2017 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, the M1 marker Interleukin (IL)-1β and tumor necrosis factor (TNF)-α were increased in depression mice while the M1 marker IL-6 and M2 marker IL-10 remained unchanged.
|
29574669 |
2018 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Having in mind the hypothesis of impaired cytokine regulation in depressive disorder, as well as the diverse population-dependent results for cytokine polymorphisms, we investigated the relation between the cytokine gene polymorphisms of key pro- and anti-inflammatory cytokines (TNF-α, TGF-β, IL-10, IL-6, IFN-γ) and susceptibility as well as clinical course of depression in Bulgarians.
|
27049572 |
2016 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Higher TNF-α and IL-6 levels in schizophrenia patients were associated with depression, physical comorbidity, and mental well-being.
|
27840055 |
2017 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, NR decreased the number of activated microglia in the hippocampus, and it reduced the levels of pro-inflammatory (IL-1β, IL-6, and TNF-α) and anti-inflammatory (IL-10 and TGF-β) cytokines in the brain of mice with alcohol-induced depression.
|
31820774 |
2020 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, levels of serum CRP, IL-6, TNF-α and BDNF can be used as judgment indicators for the severity of depression.
|
29849779 |
2018 |