|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of tumor necrosis factor-alpha and interferon-gamma mRNA in blood cells correlates with depression scores during an acute attack in patients with multiple sclerosis.
|
12084660 |
2002 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
-308(G/A) TNF-alpha gene polymorphism and risk of depression late in the life.
|
19836613 |
2009 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In inflammatory cytokines, increased cytokines [including interleukin (IL) 1beta, IL-18, tumor necrosis factor alpha] after stroke lead to depression.
|
19891854 |
2009 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The TNF-alpha A allele was associated with worsened labile anger (F = 2.5; P < 0.05) and fatigue (F = 2.9; P < 0.05) during treatment but not with major depression incidence (chi = 0.0; P = 0.99) or increased Beck Depression Inventory II (F = 1.2; P = 0.31).
|
20661026 |
2010 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Markers of impaired cellular immunity (decreased natural killer cell cytotoxicity) and inflammation (elevated IL-6, TNFα, and CRP) have been associated with depression.
|
20955778 |
2011 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The depression-like behavior was virtually abolished in TNFα p55 receptor-knockout mice, and increased B1 receptor mRNA expression was completely absent in this mouse strain.
|
21194425 |
2010 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Findings across the literature suggest that functional allelic variants of genes for interleukin-1beta (IL)-1β, tumor necrosis factor-alpha (TNF-α) and C-reactive protein (CRP), as well as genetic variations affecting T-cell function, may increase the risk for depression.
|
22580182 |
2013 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The associations between physical disorders and incident depression were significant in the presence of 2 alleles related to higher proinflammatory cytokine production (tumor necrosis factor-α -850T and IL-8 -251A), and 1 allele related to lower anti-inflammatory cytokine production (IL-4 +33C).
|
22921153 |
2013 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we tested the leukocyte mRNA expression levels of genes belonging to glucocorticoid receptor (GR) function (FKBP-4, FKBP-5, and GR), inflammation (interleukin (IL)-1α, IL-1β, IL-4, IL-6, IL-7, IL-8, IL-10, macrophage inhibiting factor (MIF), and tumor necrosis factor (TNF)-α), and neuroplasticity (brain-derived neurotrophic factor (BDNF), p11 and VGF), in healthy controls (n=34) and depressed patients (n=74), before and after 8 weeks of treatment with escitalopram or nortriptyline, as part of the Genome-based Therapeutic Drugs for Depression study.
|
22990943 |
2013 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Depression after myocardial infarction: TNF-α-induced alterations of the blood-brain barrier and its putative therapeutic implications.
|
23415700 |
2013 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
We have assessed TNF(-/-), TNF-R1(-/-) and TNF-R2(-/-) mice against C57BL/6 wild-type (WT) mice from 12 weeks of age in order to evaluate measures of spatial memory and learning in the Barnes maze (BM) and Y-maze, as well as other behaviours such as exploration, social interaction, anxiety and depression-like behaviour in a battery of tests.
|
24094876 |
2013 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Monitoring candidate gene expression variations before, during and after a first major depressive episode in a 51-year-old man.
|
24620999 |
2014 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
We demonstrated that prenatal stress leads to depression-like behavior, decreased IGF-1, increased IL-1β, TNF-α and IFN-γ release and disturbed SOCS-1, SOCS-2 and SOCS-3 expression in the hippocampus and frontal cortex of adult offspring.
|
25151093 |
2014 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
TNF-α -308G/A and IL-8 -251T/A were significantly associated with AD and IL-1β +3953C/T with late-life depression, while the significance of these associations was lost after Bonferroni correction.
|
25315113 |
2015 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
TNF was not a moderator of the effects of either interpersonal or non-interpersonal stress on later depression outcomes.
|
25596176 |
2015 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Ketamine suppressed the production of the only established depression-relevant proinflammatory cytokines, IL-6 and TNFα.
|
25903726 |
2015 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
We hypothesized that chronic peripheral inflammation in the human TNF-α transgenic (TNFtg) mouse model of rheumatoid arthritis spreads into the central nervous system and induces depressive state manifested in specific behavioral pattern and impaired adult hippocampal neurogenesis.
|
26074461 |
2015 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest that TNFα plays a critical role in mediating UCMS-induced depression through up-regulation of IDO and subsequent damage of cortical neurons.
|
26083579 |
2016 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Long-term potentiation and depression are reduced in colitic animals, and the synaptic alterations are reversed if microglial activation and tumor necrosis factor α synthesis within the brain are blocked.
|
26378439 |
2015 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Markers exhibiting the most consistent associations with depression include tumour necrosis factor-α, flow-mediated dilation, endothelin-1, endothelial progenitor cells, brain-derived neurotrophic factor, and docosahexaenoic acid.
|
26812919 |
2016 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Having in mind the hypothesis of impaired cytokine regulation in depressive disorder, as well as the diverse population-dependent results for cytokine polymorphisms, we investigated the relation between the cytokine gene polymorphisms of key pro- and anti-inflammatory cytokines (TNF-α, TGF-β, IL-10, IL-6, IFN-γ) and susceptibility as well as clinical course of depression in Bulgarians.
|
27049572 |
2016 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this review article, we focus on recent evidence linking TNF-α and MDD looking at data from animal and clinical studies, illustrating the pathophysiological role, susceptibility and its therapeutic application in depression.
|
27187381 |
2016 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, only passive coping rats exhibited increased proinflammatory proteins (IL-1β, TNF-α, GM-CSF) in the locus coeruleus (LC), a noradrenergic brain region implicated in depression.
|
27592314 |
2017 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Higher TNF-α and IL-6 levels in schizophrenia patients were associated with depression, physical comorbidity, and mental well-being.
|
27840055 |
2017 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Compelling evidence supports the involvement of the pro-inflammatory cytokines, IL-6, IFN-α and TNF-α in depression and related stress-associated pathologies.
|
27876634 |
2017 |