|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Ro60 ameliorated colitis severity and reduced the levels of tumor necrosis factor α, IL-6, IL-17, IL-8, and vascular endothelial growth factor.
|
30395870 |
2018 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The detected concentrations of the two cytokines TNF-α and IL-6 showed that their levels decreased after TRYP treatment of the colitis.
|
29724065 |
2018 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Myeloperoxidase activity and levels of TNF-α in colonic tissue were notably greater in both groups with colitis compared to controls.
|
29871733 |
2018 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
<b>Materials and Methods:</b> Healthy human colonic mucosal strips (4 × 10 mm) were incubated in carbogenated culture medium at 37°C for 16 h. Proinflammatory cytokines TNFα and IL-1β (each 10 ng/mL) were used to induce colitis in mucosal strips, and the effects of Panx1 and P2X7R on cytokines-induced tissue damage were determined in the presence of the Panx1 channel blocker <sup>10</sup>Panx1 (100 μM) and P2X7R antagonist A438079 (100 μM).
|
30127744 |
2018 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Treatment with DR-10, ML-7, SR-7 and MF-7 also significantly inhibited the local secretion of pro-inflammatory cytokines TNF-α and IL-6 and markedly decreased the gene expression of pro-inflammatory cytokines, including TNF-α, IL-6, IL-17, IL-1β, IFN-γ and MCP-1, in DSS-induced mice colitis.
|
30462121 |
2018 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor Necrosis Factor Ligand-Related Molecule 1A Regulates the Occurrence of Colitis-Associated Colorectal Cancer.
|
29796912 |
2018 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We further found that GWT suppressed mRNA expression of tumor necrosis factor-<i>α</i> (TNF-<i>α</i>) and interleukin-12 (IL-12) in macrophage and reduced TNF-<i>α</i> mRNA expression in specimens with experimental colitis, which is in contrast to VSL#3 that enhanced TNF-<i>α</i> production.
|
29862296 |
2018 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The tumor necrosis factor⁻related weak inducer of apoptosis (TWEAK) belongs to the tumor necrosis factor ligand superfamily, which was shown to play an important role in inflammatory and malignant gastrointestinal diseases, including colitis or colorectal cancer.
|
30011858 |
2018 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In particular, P. oleracea extracts also inhibited pro-inflammatory cytokine (TNF-α, IL-6, and 1L-1β) production in mice with DSS-induced colitis; the P. oleracea extracts displayed higher and/or similar inhibitory activity to sulfasalazine at high concentrations.
|
29579933 |
2018 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, the results indicate that the protective effects of TI-1-162 against colon inflammation and epithelial cell death are associated with its inhibitory action in RIP/ASK-1/MAPK signaling pathway downstream to TNF receptor 1.
|
29555502 |
2018 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The present study identified that the expression level of DRA was reduced in active UC patients and DSS‑induced colitis mice with high expression levels of TNF‑α identified in the peripheral blood serum.
|
29286110 |
2018 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In a prospective, multicenter, one-year study biologic naïve patients aged 25-65 years, with corticosteroid-dependent or refractory colitis received combination treatment with anti-TNFα and azathioprine for 6 months followed by anti-TNFα monotherapy.
|
27866814 |
2017 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MIR301A-knockout mice were resistant to the development of colitis following administration of DSS; their colon tissues expressed lower levels of interleukin 1β (IL1β), IL6, IL8, and tumor necrosis factor than colons of control mice.
|
28193514 |
2017 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Inulins inhibited the development of dextran sulfate sodium-induced colitis and colon cancer in mice; these fructans reduced the concentration of tumor necrosis factor alpha and prevented the formation of intestinal polyps, villous atrophy, and lymphoid hyperplasia.
|
28293641 |
2017 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Administration of LMWH-NP at 500 IU/kg has markedly improved the clinical activity as compared to LMWH while similarly pathophysiological indicators revealed increased therapeutic outcome in presence of NP compared to LMWH alone: Myeloperoxidase (Colitis control: 10 480 ± 5335, LMWH-PEMT-A NP: 1507 ± 2165, LMWH-PEMT-B NP: 382 ± 143, LMWH: 8549 ± 5021 units/g) and tumor necrosis factor: (Colitis control: 1636 ± 544, LMWH-PEMT-A NP: 511 ± 506, LMWH-PEMT-B NP: 435 ± 473, LMWH: 1110 ± 309 pg/g).
|
28509629 |
2017 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Mechanically, reduced NF-κВ DNA phosphorylation activity and downregulated TNF-α, IL-1β, IL-6, IL-17 expressions and myeloperoxidase (MPO) activity were associated with improvement in colitis observed in APS-treated mice.
|
28188801 |
2017 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
However a role of TNF-α in the regulation of NHE-2 is discounted in the present model of colitis.
|
28493993 |
2017 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our results showed that ginsenoside Rg1 markedly reduces proinflammatory cytokines release upon DSS stimulation of mouse dendritic cells, that ginsenoside Rg1 suppresses IL-1β (Interleukin 1 beta) and TNF-α (Tumor necrosis factor alpha) release via up-regulation of NLRP12 (NACHT, LRR and PYD domains-containing protein 12) expression, and that ginsenoside Rg1 significantly decreases the inflammatory response to DSS-induced mouse colitis, as evidenced by increased body weight, reduced colonic damage scores and disease activity index (DAI), and lowered proinflammatory cytokines levels.
|
28605639 |
2017 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The loss of NLRX1 results in increased disease severity, populations of Th1 and Th17 cells, and inflammatory markers (IFN-γ, TNF-α, and IL-17) in mice with dextran sodium sulfate-induced colitis.
|
28159898 |
2017 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Colitis was induced in mice by transfer of CD4+CD45RB<sup>hi</sup> to FcγR<sup>-/-</sup>Rag1<sup>-/-</sup> or Rag1<sup>-/-</sup> littermates; mice were given different antibodies against TNF or isotype (control) antibodies and disease activity index scores were determined.
|
28756234 |
2017 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In mice with colitis, ultrasound delivery of unencapsulated siRNA against Tnf mRNA reduced protein levels of TNF in colon tissues, compared with mice with colitis given siRNA against Tnf mRNA without ultrasound (P ≤ .014), and reduced features of inflammation (P ≤ 4.1 × 10<sup>-5</sup>).
|
28088460 |
2017 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
High mucosal TNFα concentrations were observed in αCTLA-4-induced colitis.
|
28967957 |
2017 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Male, but not female, α7 knockout mice displayed a significantly increased colitis severity and higher tumor necrosis factor-alpha levels as compared with their littermate wild-type mice.
|
27639096 |
2017 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We have shown that there is an inverse relationship between vagal tone and plasma TNFα level in patients with CD, and have reported, for the first time, that chronic vagus nerve stimulation has anti-inflammatory properties in a rat model of colitis and in a pilot study performed in seven patients with moderate CD.
|
28421634 |
2017 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A DNAzyme that prevents expression of GATA3 reduces colitis in mice, independently of TNF, and reduces levels of cytokines in the colon.
|
27639807 |
2017 |