|
Colitis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Additionally, huperzine A was effective to reverse colitis-induced high lucigenin-enhanced CL values and serum TNF-α levels.
|
23810507 |
2013 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore BTZO-15 reduced the ulcerated area and rectal MPO activity in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis rats without affecting rectal TNF-α levels.
|
21853095 |
2011 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, we identified a pteridine derivative, 4AZA2096, with strong inhibitory activity on TNF production and a remission- inducing effect in TNBS colitis, supporting further preclinical and clinical development of this novel TNF inhibitor for treatment of inflammatory diseases.
|
16881868 |
2006 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Recently, it has been demonstrated that TNF downregulates Klotho (KL) through the nuclear factor kappa B (NFkB) system in animal models of chronic kidney disease and colitis.
|
23634661 |
2013 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We found the BAG-1 isoform BAG-1M upregulated threefold in human Caco-2 cells following stimulation with tumor necrosis factor receptor α (TNFα) to induce a pro-inflammatory response, and up to sixfold in mouse enterocytes following treatment with dextran sodium sulfate (DSS) to induce colitis.
|
24876225 |
2014 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
OPTN-deficient mice were more susceptible to Citrobacter colitis and E. coli peritonitis, and showed reduced levels of proinflammatory TNFα in serum, diminished neutrophil recruitment to sites of acute inflammation and greater mortality, compared with wild-type mice.
|
26044960 |
2015 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Involvement of TACE in colon inflammation: a novel mechanism of regulation via SIRT-1 activation.
|
24548422 |
2014 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
SEW2871 treatment attenuated established colitis associated with decreased CD4+ T cells in colon lamina propria and reduced TNF-α and IFN-γ levels.
|
25588868 |
2015 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
High mucosal TNFα concentrations were observed in αCTLA-4-induced colitis.
|
28967957 |
2017 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We found that more inflammatory cells, with expression of tumor necrosis factor α, were infiltrated in double knockout mouse colitis compared with that in wild-type mice.
|
29350564 |
2018 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here, we use the mucosal delivery of Lactococcus lactis carrying an anti-TNFα scFv expression plasmid on a DSS-induced colitis model in mice.
|
31238939 |
2019 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Male, but not female, α7 knockout mice displayed a significantly increased colitis severity and higher tumor necrosis factor-alpha levels as compared with their littermate wild-type mice.
|
27639096 |
2017 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our study demonstrates that the LB-9 probiotic exhibits therapeutic potential for UC through suppression of TNF-α-mediated IEC apoptosis in a murine DSS-induced colitis model, with important biological implications for treatment of IBD in humans.
|
30615542 |
2019 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here we use wildtype (WT) and mice lacking Tnf (Tnf-/-) in an acute TNBS colitis model to investigate the role of TNF in colitis and how its presence or absence affects the colonic microbiota.
|
25775453 |
2015 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, this study determines the levels of miR-19a and TNF-α in both DSS-induced experimental murine colitis and human UC and further demonstrates that miR-19a might directly regulate TNF-α.
|
23795660 |
2013 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Treatment with M1 and its derivatives M2-M4 significantly inhibited TNF-alpha-induced attachment of U937 monocytic cells to HT-29 cells, which mimics the initial phase of colon inflammation.
|
19765578 |
2009 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In this study, we compared the benefits of an angiotensin-converting enzyme (ACE) inhibitor, enalapril, an angiotensin receptor blocker, losartan and their combination in dextran sodium sulfate (DSS)-induced colitis in mice by assessing the histopathological and macroscopic changes in the colon, and by measuring the expression of the pro-inflammatory interleukin 1beta (IL-1β) and tumor necrosis factor alpha (Tnf-α) genes.
|
30415241 |
2018 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Next, we orally administered GC-modified NPs loaded with TNF-α siRNA to C57BL/6 mice treated with 3% dextran sodium sulfate (DSS) to investigate their use in the treatment of colitis.
|
30315858 |
2018 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We have shown that there is an inverse relationship between vagal tone and plasma TNFα level in patients with CD, and have reported, for the first time, that chronic vagus nerve stimulation has anti-inflammatory properties in a rat model of colitis and in a pilot study performed in seven patients with moderate CD.
|
28421634 |
2017 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A DNAzyme that prevents expression of GATA3 reduces colitis in mice, independently of TNF, and reduces levels of cytokines in the colon.
|
27639807 |
2017 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Monocytes/macrophages are major producers of tumor necrosis factor-α (TNF-α), a representative cytokine that aggravates colitis.
|
24938744 |
2015 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Plant cells expressing recombinant anti-TNF fusion protein show biological activity when orally administered, exerting an immune modulatory effect through the alleviation of immune-mediated hepatitis and immune-mediated colitis.
|
27832933 |
2017 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings suggest that the combination of TNF-α- and TNFR1-binding peptide effectively improves the symptoms of TNBS-induced colitis and alleviates colonic pathological damages in rats.
|
21296062 |
2011 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
SR58611A significantly reduced the severity of colitis as well as the tissue levels of TNF-alpha, IL-1beta and IL-6.
|
18492028 |
2008 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
DSS treatment increased IL-10 and TNF levels during the acute phase of colitis, and increased IL-10 but reduced TNF levels during the recovery phase in Egfr(fl/fl)LysM-Cre mice.
|
24391216 |
2014 |