Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The p53 tumor suppressor gene and gene product are among the most diverse and complex been shown to have a direct correlation with cancer development and have been shown to occur in nearly 50% of all cancers. p53 mutations are particularly common in skin cancers and UV irradiation has been shown to be a primary cause of specific 'signature' mutations that can result in oncogenic transformation.
|
18348463 |
2008 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Targeting mutant p53 shows promise for sunscreens and skin cancer.
|
18060027 |
2007 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Genetic alterations within the p53 gene have been shown to have a direct correlation with cancer development and have been shown to occur in nearly 50% of all cancers. p53 mutations are particularly common in skin cancers and UV irradiation has been shown to be a primary cause of specific 'signature' mutations that can result in oncogenic transformation.
|
17270229 |
2007 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Analysis of skin cancer risk factors in immunosuppressed renal transplant patients shows high levels of UV-specific tandem CC to TT mutations of the p53 gene.
|
17065198 |
2007 |
Malignant neoplasm of skin
|
0.600 |
Biomarker
|
disease |
BEFREE |
These studies indicate that reconstituting p53 tumor suppressor functions in vivo by small molecular weight compounds may block the pathogenesis and progression of skin cancer.
|
18060030 |
2007 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although mammalian solar UV-induced mutation spectra were studied intensively in the aprt gene using rodent cultured cells and the UV-specific mutation pattern was confirmed, the second characteristic of the p53 mutations in human skin cancers had not been reproduced.
|
16620158 |
2007 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The transcription factor p53 is mutated in most keratinocyte carcinomas (nonmelanoma skin cancers).
|
16712710 |
2006 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The p53 codon 72 polymorphism, sunburns, and risk of skin cancer in US Caucasian women.
|
16739124 |
2006 |
Malignant neoplasm of skin
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
To ascertain whether perturbation of methylation plays a role in such carcinogenesis, the degree of methylation of p53 and p16 gene in DNA obtained from blood samples of people chronically exposed to arsenic and skin cancer subjects was studied.
|
16251483 |
2006 |
Malignant neoplasm of skin
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition to transition-type mutations at dipyrimidine sites, mutations which may be induced by the presence of oxidative DNA damage, are frequently observed in the ras oncogene and p53 tumor suppressor gene in human skin cancers of sun-exposed area and in UV-induced mouse skin cancers.
|
16465307 |
2006 |
Malignant neoplasm of skin
|
0.600 |
Biomarker
|
disease |
BEFREE |
Such epidermal p53 clones are common in chronically sun-exposed skin and have been suggested to play a role in skin cancer development.
|
15447725 |
2004 |
Malignant neoplasm of skin
|
0.600 |
Biomarker
|
disease |
BEFREE |
Indeed, in addition to transition-type mutations at dipyrimidine sites, G:C to T:A transversions, which may be induced by the presence of 8-oxoguanine during DNA replication, are frequently observed in the ras oncogene and p53 tumor suppressor gene in human skin cancers of sun-exposed areas and in UV-induced mouse skin cancers.
|
15130282 |
2004 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association of p53 arginine polymorphism with skin cancer.
|
15230885 |
2004 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We assessed the hypothesis that there is a relationship between the p53 codon 72, Pro/Pro polymorphism, cumulative arsenic exposure, and the risk of skin cancer in a hospital-based case-control study in southwestern Taiwan.
|
12635827 |
2003 |
Malignant neoplasm of skin
|
0.600 |
Biomarker
|
disease |
BEFREE |
Reduction in this range of early markers, i.e. sunburn, UVR-induced p53 in skin and strand breaks in PBL, indicate protection by dietary EPA against acute UVR-induced genotoxicity; longer-term supplementation might reduce skin cancer in humans.
|
12771037 |
2003 |
Malignant neoplasm of skin
|
0.600 |
Biomarker
|
disease |
CTD_human |
We assessed the hypothesis that there is a relationship between the p53 codon 72, Pro/Pro polymorphism, cumulative arsenic exposure, and the risk of skin cancer in a hospital-based case-control study in southwestern Taiwan.
|
12635827 |
2003 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The molecular mechanism of this carcinogenesis remains unclear, but p53 has been proposed as a mediator of this process. p53 overexpression, detected by immunohistochemistry, has frequently been reported in PK, and p53 mutations are direct results of ultraviolet (UV) skin exposure and are directly involved in most common skin cancers.
|
12859744 |
2003 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this review, we will describe different p53 mutation spectra, in relation to the various histopathological types of skin cancers such as basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and malignant melanoma as well as to the DNA repair efficiency of the patients.
|
12619107 |
2003 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
About 40-50% of all skin cancers in normal individuals and 60-80% of the DNA-repair-deficient xeroderma pigmentosum patients exhibit p53 mutations.
|
12444960 |
2002 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Hence, EMAST likely reflects a particular pattern of somatic events that are interactive with p53 mutation, particularly common in skin cancer and limited to non-invasive disease in bladder cancer.
|
12118368 |
2002 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To relate clinical observations to molecular events, the nature of p53 mutations found in skin cancers from psoriasis patients is also analyzed.
|
11702610 |
2002 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The same group of cases and controls was large enough to show an association between melanocortin 1 receptor gene polymorphism and skin cancer and to reasonably exclude an association between p53 codon 72 polymorphism and skin cancer.
|
11918717 |
2002 |
Malignant neoplasm of skin
|
0.600 |
Biomarker
|
disease |
BEFREE |
We conclude that inhibition of the premalignant AK lesions as well as a reduction in the expression of p53 and in spermidine concentrations may serve as surrogate endpoint biomarkers of DFMO and possibly other topically administered skin cancer chemopreventive agents.
|
11801552 |
2002 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study's data suggest that psoralen + ultraviolet A-induced p53 mutations may play an important part in the development of nonmelanoma skin cancer in psoralen + ultraviolet A-treated patients, but these mutations are likely to act in concert with the effects of other carcinogenic exposures, particularly ultraviolet B, in the development of skin cancer.
|
12190879 |
2002 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We also found a significant association between p53-72R homozygosity and nonmelanoma skin cancer in renal transplant recipients (basal cell carcinoma, p < 0.01; squamous cell carcinoma, p < 0.05) but not in immunocompetent patients compared with skin type matched controls. p53 sequence data revealed mutations in 30 of 70 (42.9%) nonmelanoma skin cancers, 28 (93%) of which were in the p53-72R allele.
|
12164929 |
2002 |