|
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
Adding MET or TP53 inhibitors to checkpoint inhibitors may be an attractive combination therapy in patients with lung cancer and MET amplification.
|
29568386 |
2018 |
|
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells.
|
30207732 |
2018 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Low P53RRA expression significantly correlated with poor survival in patients with breast and lung cancers harboring wild-type p53.
|
29588351 |
2018 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Epidermal Growth Factor Receptor-mutated Lung Cancer as the Initial Manifestation of Germline TP53 Mutation Associated Cancer.
|
29854570 |
2018 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
This retrospective observational study examined lung cancer tumor samples from 163 H/L patients, and tumor-derived DNA was subjected to targeted-exome sequencing (>1000 genes, including EGFR, KRAS, serine/threonine kinase 11 gene [STK11], and tumor protein p53 gene [TP53]) and ancestry analysis.
|
28911955 |
2017 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We show that lung epithelial expression of R270H and R172H (R273H and R175H in humans), common TRP53 mutants in lung cancer, combined with RB1 loss selectively results in two subtypes of neuroendocrine carcinoma, SCLC and large cell neuroendocrine carcinoma (LCNEC).
|
28847987 |
2017 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Significantly, codons 244 and 248 are mutational "hotspots" in nonsmall cell and small cell lung cancers, supporting a possible role of oxidation in p53 mutations leading to lung cancer.
|
29116749 |
2017 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We selected eight genes, ATM serine/threonine kinase gene (ATM), BRCA2, DNA repair associated gene (BRCA2), checkpoint kinase 2 gene (CHEK2), EGFR, parkin RBR E3 ubiquitin protein ligase gene (PARK2), telomerase reverse transcriptase gene (TERT), tumor protein p53 gene (TP53), and Yes associated protein 1 gene (YAP1), on the basis of prior anecdotal association with lung cancer or genome-wide association studies.
|
28843361 |
2017 |
|
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
Since blocking autophagy by lysosomal inhibitors enhanced the apoptosis-inducing effect of bromoconduritol, independent of p53 status, their combined use may hold promise for the treatment of cancer, particularly lung cancer.
|
28929344 |
2017 |
|
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
Polyvinyl pyrrolidone-coated silver nanoparticles in a human lung cancer cells: time- and dose-dependent influence over p53 and caspase-3 protein expression and epigenetic effects.
|
27387714 |
2017 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Indeed, germline mutations in the TP53 gene predispose to multiple cancer types, including LC.
|
28968711 |
2017 |
|
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
The PRR11-SKA2 Bidirectional Transcription Unit Is Negatively Regulated by p53 through NF-Y in Lung Cancer Cells.
|
28257042 |
2017 |
|
Malignant neoplasm of lung
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
The bioinformatics data substantiated our findings showing that positive correlation between G9a and p53 expression is associated with better survival of lung cancer patients.
|
27452519 |
2017 |
|
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
The tumor suppressor p53 regulates autophagosomal and lysosomal biogenesis in lung cancer cells by targeting transcription factor EB.
|
28292013 |
2017 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We further tested 85 unrelated Arab cancer patients and father of a BC carrier patient for TP53 c.541C>T using a real time polymerase chain reaction (RT-PCR) approach and identified four additional carriers, two with BC one with lung cancer, and the father of a BC carrier patient, diagnosed with GBM.
|
27866339 |
2017 |
|
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
However, the interaction of ROR, p53 and miR-145 in lung cancer and its correlation with lung cancer stem cell (LCSC) signatures were not fully understood.
|
28516515 |
2017 |
|
Malignant neoplasm of lung
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Correlation of MMP-9 and p53 protein expression with prognosis in metastatic spinal tumor of lung cancer.
|
29113175 |
2017 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Endoplasmic Reticulum Stress Promotes Autophagy and Apoptosis and Reduces Chemotherapy Resistance in Mutant p53 Lung Cancer Cells.
|
29130967 |
2017 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Concurrent mutations, specifically TP53, are common in EGFR mutated lung cancer and may alter clinical outcomes.
|
28285689 |
2017 |
|
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
TP53 gene status is a critical determinant of phenotypes induced by ALKBH3 knockdown in non-small cell lung cancers.
|
28479246 |
2017 |
|
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
Our findings provide us with new insights regarding the mechanism by which p53 mediates A549 apoptosis and may cast light on the development of more efficient p53-based strategies for treating lung cancer.
|
28662516 |
2017 |
|
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
The aim of the current study is to elucidate the correlation of HOXA5 and p53 in tumor invasion and its prognostic influence in lung cancer patient specimens.
|
28529621 |
2017 |
|
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
So the p53(DEL) is a promising target for prevention and treatment of lung cancer.
|
28631571 |
2017 |
|
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
Here, we show that mutant p53 drives the release of invasive extracellular factors (the 'secretome') that facilitates the invasion of lung cancer cell lines.
|
28368395 |
2017 |
|
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |