|
Hashimoto Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Sixty-one adult Caucasian 47,XXY KS patients were tested for autoantibodies specific to T1DM (Insulin Abs, GAD Abs, IA-2 Abs, Znt8 Abs), HT (TPO Abs), AD (21-OH Abs), and AG (APC Abs).
|
25935328 |
2016 |
|
Hashimoto Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We experienced a 6-year-old case of drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) with subsequent development autoimmune thyroiditis (Hashimoto's thyroiditis), type 1 diabetes with antithyroglobulin, thyroid peroxidase, insulinoma-associated antigen and anti-insulin antibodies at 4 months, alopecia at 7 months, vitiligo, uveitis due to Vogt-Koyanagi-Harada disease at 8 months after clinical resolution of the DiHS/DRESS.
|
30368475 |
2018 |
|
Hashimoto Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to evaluate cognitive function and quality of life (QoL) in patients on long-term levothyroxine replacement for HT in relation to thyroid function tests and TPO (thyroid-peroxidase) antibody (TPOAb) status.
|
29959689 |
2018 |
|
Hashimoto Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Individuals with positive thyroid peroxidase antibodies (TPOAbs) have an increased risk of autoimmune hypothyroidism (Hashimoto's thyroiditis), as well as autoimmune hyperthyroidism (Graves' disease).
|
24586183 |
2014 |
|
Hashimoto Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, TPO rs2071400 and rs2071403 polymorphisms were associated with the development of HD and GD, but not with the prognosis.
|
28845025 |
2017 |
|
Hashimoto Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Three genetic variants showed nominal association with HT; rs10774625 in ATXN2 gene (p = 0.0149, OR = 0.73, CI = 0.56-0.94), rs7171171 near RASGRP1 gene (p = 0.0356, OR = 1.4, CI = 1.02-1.92) and rs11675434 in TPO gene (p = 0.041, OR = 1.31, CI = 1.01-1.69).
|
27268232 |
2016 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Green coffee, green tea, cumin, and mustard contain potentially bioaccessible TPO activators that also act as effective LOX inhibitors, which indicate their potentially health-promoting effects for people suffering from Hashimoto's disease.
|
31671724 |
2019 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
In those with HT, MMP-3 correlated negatively with FT3 (rho=-0.545, P=0.048) and positively with TPO-Ab and HI (rho=0.735, P=0.02; rho=0.769, P=0.01, respectively).
|
29442475 |
2018 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The percentage positive for thyroid peroxidase (TPO) antibody and lymphocytic thyroiditis was significantly higher in the TgAb-positive group.
|
28493284 |
2017 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
A diagnosis of autoimmune thyroiditis (AT) in thyrotoxic phase was made on the basis of clinical presentation and presence of anti-TPO antibodies and reduced uptake in thyroid (technetium) scintigraphy.
|
30128632 |
2019 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Conclusions Fluctuating thyroid function tests in addition to thyroid peroxidase antibody (TPO Ab) positivity complicated the diagnosis of RTH, initially diagnosed as Hashimoto's thyroiditis.
|
30681972 |
2019 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Monozygotic twin pairs discordant for Hashimoto's thyroiditis share a high proportion of thyroid peroxidase autoantibodies to the immunodominant region A. Further evidence for genetic transmission of epitopic "fingerprints".
|
20883148 |
2011 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The presence of anti-TPO antibodies strongly suggests autoimmune thyroiditis.
|
17010173 |
2006 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The TPO epitope cDNA library consisting of randomly fragmented cDNA sequences inserted in the expression vector pGEX-2T was expressed in Escherichia coli and screened with characterized anti-TPO autoantisera from Hashimoto's disease patients.
|
1379223 |
1992 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
In our study, prevalence of TPO-Ab positivity is more frequent in subjects with <i>H. pylori</i> infection.Our findings suggest <i>H. pylori</i> infection may play a role in the development of autoimmune thyroiditis.
|
28092700 |
2017 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Modulation of T cell function by alpha-fetoprotein: An in vivo study on porcine thyroid peroxidase-induced experimental autoimmune thyroiditis in transgenic mice producing human alpha-fetoprotein.
|
10213924 |
1999 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our key and novel finding is the existence of significant positive correlation between TgAb levels and the number of symptoms (r = 0.25, p = 0.0001) in HT patients without LT4 therapy that remained significant after adjustment for TPOAb, T3, TSH levels and thyroid volume (β = 0.66, SE = 0.3, p = 0.0299).
|
30332318 |
2019 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Autoimmunity to TPO is characterised by autoantibodies and T cell reactivity in Hashimoto's disease and Graves' disease.
|
30742860 |
2019 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to explore the effect of Se on thyroid peroxidase antibody (TPOAb) titers in patients with AIT and to analyze a potential impact of the genetic background on the effect of Se supplementation Methods Randomized, placebo-controlled, double-blind trial.
|
30398407 |
2018 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study included 933 patients with thyroid peroxidase antibodies (anti-TPO-Ab) ≥34 kIU/l, including most patients with clear AIT due to a concurrent sonographic evidence of reduced echogenicity.
|
31766063 |
2019 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that the interaction between the HLA-DRB4 and CTLA-4 genes determines the thyroid function of TPO-positive goitrous Japanese HT patients.
|
15055474 |
2003 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Antibodies to thyroid peroxidase (TPO), the enzyme that catalyses thyroid-hormone production and antibodies to the receptor for the thyroid-stimulating hormone, are characteristic of HT and GD, respectively.
|
30208979 |
2019 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study was undertaken to investigate if any specific KIR gene(s) is associated with the susceptibility to Hashimoto's thyroiditis (HT), an inflammatory disease characterized by lymphocytic infiltration of the thyroid gland and the presence of autoantibodies directed against thyroglobulin and/or thyroid peroxidase.
|
24174177 |
2014 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The prevalence of anti thyroperoxidase (TPO) was significantly increased in the autoimmune thyroiditis (AIT).
|
30807792 |
2019 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Only data from patients with laboratory-confirmed HT (anti-thyroid peroxidase [anti-TPO] antibodies; thyroglobulin antibodies; serum thyroid-stimulating hormone; and free T3) were eligible for inclusion.
|
28217937 |
2017 |