|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The TPO epitope cDNA library consisting of randomly fragmented cDNA sequences inserted in the expression vector pGEX-2T was expressed in Escherichia coli and screened with characterized anti-TPO autoantisera from Hashimoto's disease patients.
|
1379223 |
1992 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The enzyme thyroid peroxidase (TPO) plays a central role in thyroid hormone synthesis and is the target for the autoimmune attack in lymphocytic thyroiditis.
|
2742742 |
1989 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Modulation of T cell function by alpha-fetoprotein: An in vivo study on porcine thyroid peroxidase-induced experimental autoimmune thyroiditis in transgenic mice producing human alpha-fetoprotein.
|
10213924 |
1999 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that the interaction between the HLA-DRB4 and CTLA-4 genes determines the thyroid function of TPO-positive goitrous Japanese HT patients.
|
15055474 |
2003 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The upregulation of both the number and the matured functions of DCs, may lead to present more antigens and to produce more auto-antibodies (such as Tg-Ab and TPO-Ab in HT, TR-Ab in GD), which may be involved in pathogenesis of the autoimmune thyroid diseases.
|
16285898 |
2004 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
It has been reported that serum of patients with RTH lacks autoantibodies against thyroglobulin (Tg) and thyroid peroxidase (TPO), except in rare cases where there is co-occurrence of coincidental autoimmune thyroiditis.
|
16723809 |
2006 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The presence of anti-TPO antibodies strongly suggests autoimmune thyroiditis.
|
17010173 |
2006 |
|
Hashimoto Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Autoimmune thyroiditis with raised levels of thyroperoxidase antibodies (TPO-Abs) is related to bipolar disorder and may be such an endophenotype.
|
17141745 |
2007 |
|
Hashimoto Disease
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Effects of 12 months treatment with L-selenomethionine on serum anti-TPO Levels in Patients with Hashimoto's thyroiditis.
|
17696828 |
2007 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hyperthyroidism in Graves' disease is caused by thyroid-stimulating autoantibodies to the TSH receptor (TSHR), whereas hypothyroidism in Hashimoto's thyroiditis is associated with thyroid peroxidase and thyroglobulin autoantibodies.
|
17823263 |
2007 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Independent risk factors for events were baseline findings for TSH and TPO antibodies in a level-dependent relationship (for TSH the risk already starts to increase at values >2.0 mIU/L) and family background (with the greatest risk attached to subjects having 2 relatives with Hashimoto disease).
|
18695079 |
2008 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Monozygotic twin pairs discordant for Hashimoto's thyroiditis share a high proportion of thyroid peroxidase autoantibodies to the immunodominant region A. Further evidence for genetic transmission of epitopic "fingerprints".
|
20883148 |
2011 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study was undertaken to investigate if any specific KIR gene(s) is associated with the susceptibility to Hashimoto's thyroiditis (HT), an inflammatory disease characterized by lymphocytic infiltration of the thyroid gland and the presence of autoantibodies directed against thyroglobulin and/or thyroid peroxidase.
|
24174177 |
2014 |
|
Hashimoto Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Individuals with positive thyroid peroxidase antibodies (TPOAbs) have an increased risk of autoimmune hypothyroidism (Hashimoto's thyroiditis), as well as autoimmune hyperthyroidism (Graves' disease).
|
24586183 |
2014 |
|
Hashimoto Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Sixty-one adult Caucasian 47,XXY KS patients were tested for autoantibodies specific to T1DM (Insulin Abs, GAD Abs, IA-2 Abs, Znt8 Abs), HT (TPO Abs), AD (21-OH Abs), and AG (APC Abs).
|
25935328 |
2016 |
|
Hashimoto Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Three genetic variants showed nominal association with HT; rs10774625 in ATXN2 gene (p = 0.0149, OR = 0.73, CI = 0.56-0.94), rs7171171 near RASGRP1 gene (p = 0.0356, OR = 1.4, CI = 1.02-1.92) and rs11675434 in TPO gene (p = 0.041, OR = 1.31, CI = 1.01-1.69).
|
27268232 |
2016 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum immunoglobulin G antibodies against H pylori (enzyme-linked immunosorbent assay), CagA protein (Western blot assay), circulating antibodies to thyroid antigens, mainly thyroperoxidase (TPOAbs) and thyroglobulin (TgAbs), were tested in 101 females with HT and 111 non-HT control women without a history of autoimmune disease.
|
27442635 |
2016 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
<i>Results.</i> The percentage of CRTH2+ lymphocytes was higher in nodules with HT in comparison with controls, both in FNAB samples (13.95 versus 6.7%, <i>p</i> = 0.008) and in peripheral blood (6.7 versus 5.13%, <i>p</i> = 0.047), and positively correlated with serum antibodies to thyroid peroxidase (<i>r</i> = 0.243; <i>p</i> = 0.026) and negatively correlated with thyroid volume (<i>r</i> = -0.346; <i>p</i> = 0.008).
|
27872865 |
2016 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
In our study, prevalence of TPO-Ab positivity is more frequent in subjects with <i>H. pylori</i> infection.Our findings suggest <i>H. pylori</i> infection may play a role in the development of autoimmune thyroiditis.
|
28092700 |
2017 |
|
Hashimoto Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The procalcitonin and anti-thyroid peroxidase levels were identified to be an independent predictor in diagnosis of Hashimoto's thyroiditis.
|
28171686 |
2017 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Only data from patients with laboratory-confirmed HT (anti-thyroid peroxidase [anti-TPO] antibodies; thyroglobulin antibodies; serum thyroid-stimulating hormone; and free T3) were eligible for inclusion.
|
28217937 |
2017 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The percentage positive for thyroid peroxidase (TPO) antibody and lymphocytic thyroiditis was significantly higher in the TgAb-positive group.
|
28493284 |
2017 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
To study the prevalence of Hashimoto thyroiditis (HT), anti-thyroid autoantibodies (anti-thyroglobulin or TgAb and thyroperoxidase or TPOAb) in systemic lupus erythematosus (SLE) patients.
|
28544477 |
2018 |
|
Hashimoto Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
It is generally believed that the detection of thyroid peroxidase antibodies (TPOAb) is superior to that of thyroglobulin antibodies (TgAb) for the diagnosis of Hashimoto's thyroiditis.
|
28768936 |
2017 |
|
Hashimoto Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, TPO rs2071400 and rs2071403 polymorphisms were associated with the development of HD and GD, but not with the prognosis.
|
28845025 |
2017 |