|
Abnormal behavior
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Several investigations have reported that the translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) was associated with major psychiatric disorders including schizophrenia, bipolar disorder (BP), and major depressive disorder (MDD).
|
19760522 |
2010 |
|
Abnormal behavior
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
In the present review, we will focus on the emerging roles of TRAX and its interacting proteins (including DISC1 and GSK3β) in psychiatric disorders and the potential implications for developing therapeutic interventions.
|
30285728 |
2018 |
|
Abnormal behavior
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
The translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) has been associated with psychiatric disorders, including schizophrenia, MDD and bipolar disorder.
|
21683752 |
2011 |
|
Asperger Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here we have addressed the allelic diversity of the DISC1, DISC2 and TRAX genes, clustered in 1q42, in Finnish families ascertained for infantile autism (97 families, n(affected)=138) and Asperger syndrome (29 families, n(affected)=143).
|
17579608 |
2008 |
|
Autism Spectrum Disorders
|
0.010 |
Biomarker
|
disease |
BEFREE |
While this case provides evidence for the potential role of DISC1, DISC2, and TSNAX in the development of autism spectrum disorders, it is equally clear that caution must be taken when providing families with prognostic information and genetic counseling regarding such deletions.
|
19606485 |
2009 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
BEFREE |
Several investigations have reported that the translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) was associated with major psychiatric disorders including schizophrenia, bipolar disorder (BP), and major depressive disorder (MDD).
|
19760522 |
2010 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
Several investigations have reported that the translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) was associated with major psychiatric disorders including schizophrenia, bipolar disorder (BP), and major depressive disorder (MDD).
|
19760522 |
2010 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
BEFREE |
The translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) has been associated with psychiatric disorders, including schizophrenia, MDD and bipolar disorder.
|
21683752 |
2011 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
Two further regions, one in TRAX and the second in DISC1, showed weaker evidence for sex-specific associations of individual haplotypes with bipolar disorder in men and women respectively, P<0.01.
|
15838535 |
2005 |
|
Bipolar Disorder
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Two further regions, one in TRAX and the second in DISC1, showed weaker evidence for sex-specific associations of individual haplotypes with bipolar disorder in men and women respectively, P<0.01.
|
15838535 |
2005 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
The translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) has been associated with psychiatric disorders, including schizophrenia, MDD and bipolar disorder.
|
21683752 |
2011 |
|
Bipolar Disorder
|
0.330 |
GeneticVariation
|
disease |
LHGDN |
Two further regions, one in TRAX and the second in DISC1, showed weaker evidence for sex-specific associations of individual haplotypes with bipolar disorder in men and women respectively, P<0.01.
|
15838535 |
2005 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Translin and Trax proteins are highly conserved nucleic acid binding proteins that have been implicated in RNA regulation in a range of biological processes including tRNA processing, RNA interference, microRNA degradation during oncogenesis, spermatogenesis and neuronal regulation.
|
27183912 |
2016 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Translin, and its binding partner protein TRAX (translin-associated factor-X) are a paralogous pair of conserved proteins, which have been implicated in a broad spectrum of biological activities, including cell growth regulation, mRNA processing, spermatogenesis, neuronal development/function, genome stability regulation and carcinogenesis, although their precise role in some of these processes remains unclear.
|
20578993 |
2010 |
|
Depressed mood
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies.
|
19255581 |
2010 |
|
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies.
|
19255581 |
2010 |
|
Endometrial Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, by high-throughput RNA sequencing in nine paired human endometrial carcinoma (EC) and matched non-cancerous tissues, we obtained that chimeric translin-associated factor X-disrupted-in-schizophrenia 1 (TSNAX-DISC1) occurred significantly upregulated in multiple EC samples.
|
25239642 |
2014 |
|
Major Depressive Disorder
|
0.030 |
Biomarker
|
disease |
BEFREE |
The translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) has been associated with psychiatric disorders, including schizophrenia, MDD and bipolar disorder.
|
21683752 |
2011 |
|
Major Depressive Disorder
|
0.030 |
Biomarker
|
disease |
BEFREE |
Translin-associated factor X gene (TSNAX) may be associated with female major depressive disorder in the Japanese population.
|
19760522 |
2010 |
|
Major Depressive Disorder
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Evidence of association among rs3738401 (DISC1), rs1615409 and rs766288 (TSNAX) and MDD was found (p=0.004, p=0.0019, and p=0.008, respectively).
|
25043320 |
2014 |
|
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Dysregulation of TSNAX influences steroidogenic factor-1-stimulated transcription on the StAR promoter, altering progesterone actions, implying the association with cancer.
|
25239642 |
2014 |
|
Mental Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies.
|
19255581 |
2010 |
|
Mental disorders
|
0.050 |
GeneticVariation
|
group |
BEFREE |
The TSNAX (Translin-associated factor X) gene, located immediately upstream of DISC1, has also been suggested as a candidate gene in relation to psychiatric illness, as one transcript resulting from intergenic splicing encodes a novel TSNAX-DISC1 fusion protein.
|
19255581 |
2010 |
|
Mental disorders
|
0.050 |
Biomarker
|
group |
BEFREE |
GSK3β negatively regulates TRAX, a scaffold protein implicated in mental disorders, for NHEJ-mediated DNA repair in neurons.
|
29298990 |
2018 |
|
Mental disorders
|
0.050 |
Biomarker
|
group |
BEFREE |
The translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) has been associated with psychiatric disorders, including schizophrenia, MDD and bipolar disorder.
|
21683752 |
2011 |