TSNAX, translin associated factor X, 7257

N. diseases: 19; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.030 Biomarker disease BEFREE Translin-associated factor X gene (TSNAX) may be associated with female major depressive disorder in the Japanese population. 19760522 2010
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.020 Biomarker disease BEFREE Translin-associated factor X gene (TSNAX) may be associated with female major depressive disorder in the Japanese population. 19760522 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease BEFREE Translin-associated protein X (TRAX) is a scaffold protein with various functions and has been associated with mental illnesses, including schizophrenia. 29298990 2018
CUI: C0524528
Disease: Pervasive Development Disorder
Pervasive Development Disorder 		0.010 Biomarker group BEFREE A 1q42 deletion involving DISC1, DISC2, and TSNAX in an autism spectrum disorder. 19606485 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 GeneticVariation disease BEFREE Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population. 15838535 2005
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.310 Biomarker group PSYGENET Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies. 19255581 2010
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.310 Biomarker group BEFREE Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies. 19255581 2010
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.010 Biomarker disease BEFREE Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies. 19255581 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.010 Biomarker disease BEFREE Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies. 19255581 2010
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.010 Biomarker phenotype BEFREE Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies. 19255581 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 GeneticVariation disease BEFREE Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia. 10945471 2000
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.020 Biomarker disease BEFREE DISC1-TSNAX and DAOA genes in major depression and citalopram efficacy. 25043320 2014
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.010 AlteredExpression group BEFREE Dysregulation of TSNAX influences steroidogenic factor-1-stimulated transcription on the StAR promoter, altering progesterone actions, implying the association with cancer. 25239642 2014
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.010 AlteredExpression group BEFREE Dysregulation of TSNAX influences steroidogenic factor-1-stimulated transcription on the StAR promoter, altering progesterone actions, implying the association with cancer. 25239642 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.030 GeneticVariation disease BEFREE Evidence of association among rs3738401 (DISC1), rs1615409 and rs766288 (TSNAX) and MDD was found (p=0.004, p=0.0019, and p=0.008, respectively). 25043320 2014
CUI: C0004936
Disease: Mental disorders
Mental disorders 		0.050 Biomarker group BEFREE GSK3β negatively regulates TRAX, a scaffold protein implicated in mental disorders, for NHEJ-mediated DNA repair in neurons. 29298990 2018
CUI: C0236792
Disease: Asperger Syndrome
Asperger Syndrome 		0.010 GeneticVariation disease BEFREE Here we have addressed the allelic diversity of the DISC1, DISC2 and TRAX genes, clustered in 1q42, in Finnish families ascertained for infantile autism (97 families, n(affected)=138) and Asperger syndrome (29 families, n(affected)=143). 17579608 2008
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.010 Biomarker disease BEFREE Here, by high-throughput RNA sequencing in nine paired human endometrial carcinoma (EC) and matched non-cancerous tissues, we obtained that chimeric translin-associated factor X-disrupted-in-schizophrenia 1 (TSNAX-DISC1) occurred significantly upregulated in multiple EC samples. 25239642 2014
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 GeneticVariation disease BEFREE Here, we tested if the identified allelic haplotypes of TRAX/DISC would be associated with visual and/or verbal memory function impairments that are known to aggregate with schizophrenia in families. 16103888 2005
CUI: C0004936
Disease: Mental disorders
Mental disorders 		0.050 Biomarker group BEFREE In the present review, we will focus on the emerging roles of TRAX and its interacting proteins (including DISC1 and GSK3β) in psychiatric disorders and the potential implications for developing therapeutic interventions. 30285728 2018
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.030 Biomarker phenotype BEFREE In the present review, we will focus on the emerging roles of TRAX and its interacting proteins (including DISC1 and GSK3β) in psychiatric disorders and the potential implications for developing therapeutic interventions. 30285728 2018
CUI: C1533217
Disease: Methamphetamine dependence
Methamphetamine dependence 		0.010 Biomarker disease BEFREE Lack of association between translin-associated factor X gene (TSNAX) and methamphetamine dependence in the Japanese population. 21683752 2011
CUI: C0004936
Disease: Mental disorders
Mental disorders 		0.050 Biomarker group BEFREE Several investigations have reported that the translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) was associated with major psychiatric disorders including schizophrenia, bipolar disorder (BP), and major depressive disorder (MDD). 19760522 2010
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.030 Biomarker phenotype BEFREE Several investigations have reported that the translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) was associated with major psychiatric disorders including schizophrenia, bipolar disorder (BP), and major depressive disorder (MDD). 19760522 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease BEFREE Several investigations have reported that the translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) was associated with major psychiatric disorders including schizophrenia, bipolar disorder (BP), and major depressive disorder (MDD). 19760522 2010