TSNAX, translin associated factor X, 7257

N. diseases: 19; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease BEFREE Translin-associated protein X (TRAX) is a scaffold protein with various functions and has been associated with mental illnesses, including schizophrenia. 29298990 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease BEFREE The translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) has been associated with psychiatric disorders, including schizophrenia, MDD and bipolar disorder. 21683752 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease BEFREE Several investigations have reported that the translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) was associated with major psychiatric disorders including schizophrenia, bipolar disorder (BP), and major depressive disorder (MDD). 19760522 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 GeneticVariation disease BEFREE Specific alleles of the DISC1 and TRAX genes on 1q42 appear to contribute to genetic risk for schizophrenia through disruptive effects on the structure and function of the prefrontal cortex, medial temporal lobe, and other brain regions. 16275808 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 GeneticVariation disease BEFREE Here, we tested if the identified allelic haplotypes of TRAX/DISC would be associated with visual and/or verbal memory function impairments that are known to aggregate with schizophrenia in families. 16103888 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 GeneticVariation disease BEFREE Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population. 15838535 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 GeneticVariation disease BEFREE The present study suggests that the DISC1/TRAX locus may not have a major role in Japanese schizophrenia. 16039834 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 GeneticVariation disease BEFREE Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia. 10945471 2000
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 Biomarker disease BEFREE The translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) has been associated with psychiatric disorders, including schizophrenia, MDD and bipolar disorder. 21683752 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 Biomarker disease PSYGENET The translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) has been associated with psychiatric disorders, including schizophrenia, MDD and bipolar disorder. 21683752 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 Biomarker disease BEFREE Several investigations have reported that the translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) was associated with major psychiatric disorders including schizophrenia, bipolar disorder (BP), and major depressive disorder (MDD). 19760522 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 Biomarker disease PSYGENET Several investigations have reported that the translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) was associated with major psychiatric disorders including schizophrenia, bipolar disorder (BP), and major depressive disorder (MDD). 19760522 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 Biomarker disease PSYGENET Two further regions, one in TRAX and the second in DISC1, showed weaker evidence for sex-specific associations of individual haplotypes with bipolar disorder in men and women respectively, P<0.01. 15838535 2005
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 GeneticVariation disease BEFREE Two further regions, one in TRAX and the second in DISC1, showed weaker evidence for sex-specific associations of individual haplotypes with bipolar disorder in men and women respectively, P<0.01. 15838535 2005
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 GeneticVariation disease LHGDN Two further regions, one in TRAX and the second in DISC1, showed weaker evidence for sex-specific associations of individual haplotypes with bipolar disorder in men and women respectively, P<0.01. 15838535 2005
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.310 Biomarker group PSYGENET Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies. 19255581 2010
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.310 Biomarker group BEFREE Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies. 19255581 2010
CUI: C0004936
Disease: Mental disorders
Mental disorders 		0.050 Biomarker group BEFREE GSK3β negatively regulates TRAX, a scaffold protein implicated in mental disorders, for NHEJ-mediated DNA repair in neurons. 29298990 2018
CUI: C0004936
Disease: Mental disorders
Mental disorders 		0.050 Biomarker group BEFREE In the present review, we will focus on the emerging roles of TRAX and its interacting proteins (including DISC1 and GSK3β) in psychiatric disorders and the potential implications for developing therapeutic interventions. 30285728 2018
CUI: C0004936
Disease: Mental disorders
Mental disorders 		0.050 Biomarker group BEFREE The translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) has been associated with psychiatric disorders, including schizophrenia, MDD and bipolar disorder. 21683752 2011
CUI: C0004936
Disease: Mental disorders
Mental disorders 		0.050 GeneticVariation group BEFREE The TSNAX (Translin-associated factor X) gene, located immediately upstream of DISC1, has also been suggested as a candidate gene in relation to psychiatric illness, as one transcript resulting from intergenic splicing encodes a novel TSNAX-DISC1 fusion protein. 19255581 2010
CUI: C0004936
Disease: Mental disorders
Mental disorders 		0.050 Biomarker group BEFREE Several investigations have reported that the translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) was associated with major psychiatric disorders including schizophrenia, bipolar disorder (BP), and major depressive disorder (MDD). 19760522 2010
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.030 Biomarker phenotype BEFREE In the present review, we will focus on the emerging roles of TRAX and its interacting proteins (including DISC1 and GSK3β) in psychiatric disorders and the potential implications for developing therapeutic interventions. 30285728 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.030 GeneticVariation disease BEFREE Evidence of association among rs3738401 (DISC1), rs1615409 and rs766288 (TSNAX) and MDD was found (p=0.004, p=0.0019, and p=0.008, respectively). 25043320 2014
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.030 Biomarker phenotype BEFREE The translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) has been associated with psychiatric disorders, including schizophrenia, MDD and bipolar disorder. 21683752 2011