Schizophrenia
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia.
|
10945471 |
2000 |
Schizophrenia
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Specific alleles of the DISC1 and TRAX genes on 1q42 appear to contribute to genetic risk for schizophrenia through disruptive effects on the structure and function of the prefrontal cortex, medial temporal lobe, and other brain regions.
|
16275808 |
2005 |
Schizophrenia
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Here, we tested if the identified allelic haplotypes of TRAX/DISC would be associated with visual and/or verbal memory function impairments that are known to aggregate with schizophrenia in families.
|
16103888 |
2005 |
Schizophrenia
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population.
|
15838535 |
2005 |
Schizophrenia
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
The present study suggests that the DISC1/TRAX locus may not have a major role in Japanese schizophrenia.
|
16039834 |
2005 |
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
Two further regions, one in TRAX and the second in DISC1, showed weaker evidence for sex-specific associations of individual haplotypes with bipolar disorder in men and women respectively, P<0.01.
|
15838535 |
2005 |
Bipolar Disorder
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Two further regions, one in TRAX and the second in DISC1, showed weaker evidence for sex-specific associations of individual haplotypes with bipolar disorder in men and women respectively, P<0.01.
|
15838535 |
2005 |
Bipolar Disorder
|
0.330 |
GeneticVariation
|
disease |
LHGDN |
Two further regions, one in TRAX and the second in DISC1, showed weaker evidence for sex-specific associations of individual haplotypes with bipolar disorder in men and women respectively, P<0.01.
|
15838535 |
2005 |
Recurrent major depressive episodes
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The Translin-associated factor X/Disrupted in Schizophrenia 1 (TRAX/DISC) region was first implicated as a susceptibility locus for schizophrenia by analysis of a large Scottish family in which a t(1;11) translocation cosegregates with schizophrenia, bipolar disorder and recurrent major depression.
|
15838535 |
2005 |
Asperger Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here we have addressed the allelic diversity of the DISC1, DISC2 and TRAX genes, clustered in 1q42, in Finnish families ascertained for infantile autism (97 families, n(affected)=138) and Asperger syndrome (29 families, n(affected)=143).
|
17579608 |
2008 |
Pervasive Development Disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
A 1q42 deletion involving DISC1, DISC2, and TSNAX in an autism spectrum disorder.
|
19606485 |
2009 |
Autism Spectrum Disorders
|
0.010 |
Biomarker
|
disease |
BEFREE |
While this case provides evidence for the potential role of DISC1, DISC2, and TSNAX in the development of autism spectrum disorders, it is equally clear that caution must be taken when providing families with prognostic information and genetic counseling regarding such deletions.
|
19606485 |
2009 |
Schizophrenia
|
0.380 |
Biomarker
|
disease |
BEFREE |
Several investigations have reported that the translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) was associated with major psychiatric disorders including schizophrenia, bipolar disorder (BP), and major depressive disorder (MDD).
|
19760522 |
2010 |
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
BEFREE |
Several investigations have reported that the translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) was associated with major psychiatric disorders including schizophrenia, bipolar disorder (BP), and major depressive disorder (MDD).
|
19760522 |
2010 |
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
Several investigations have reported that the translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) was associated with major psychiatric disorders including schizophrenia, bipolar disorder (BP), and major depressive disorder (MDD).
|
19760522 |
2010 |
Mood Disorders
|
0.310 |
Biomarker
|
group |
PSYGENET |
Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies.
|
19255581 |
2010 |
Mood Disorders
|
0.310 |
Biomarker
|
group |
BEFREE |
Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies.
|
19255581 |
2010 |
Mental disorders
|
0.050 |
GeneticVariation
|
group |
BEFREE |
The TSNAX (Translin-associated factor X) gene, located immediately upstream of DISC1, has also been suggested as a candidate gene in relation to psychiatric illness, as one transcript resulting from intergenic splicing encodes a novel TSNAX-DISC1 fusion protein.
|
19255581 |
2010 |
Mental disorders
|
0.050 |
Biomarker
|
group |
BEFREE |
Several investigations have reported that the translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) was associated with major psychiatric disorders including schizophrenia, bipolar disorder (BP), and major depressive disorder (MDD).
|
19760522 |
2010 |
Abnormal behavior
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Several investigations have reported that the translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) was associated with major psychiatric disorders including schizophrenia, bipolar disorder (BP), and major depressive disorder (MDD).
|
19760522 |
2010 |
Major Depressive Disorder
|
0.030 |
Biomarker
|
disease |
BEFREE |
Translin-associated factor X gene (TSNAX) may be associated with female major depressive disorder in the Japanese population.
|
19760522 |
2010 |
Unipolar Depression
|
0.020 |
Biomarker
|
disease |
BEFREE |
Translin-associated factor X gene (TSNAX) may be associated with female major depressive disorder in the Japanese population.
|
19760522 |
2010 |
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Translin, and its binding partner protein TRAX (translin-associated factor-X) are a paralogous pair of conserved proteins, which have been implicated in a broad spectrum of biological activities, including cell growth regulation, mRNA processing, spermatogenesis, neuronal development/function, genome stability regulation and carcinogenesis, although their precise role in some of these processes remains unclear.
|
20578993 |
2010 |
Mental Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies.
|
19255581 |
2010 |
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies.
|
19255581 |
2010 |