Non-Small Cell Lung Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of MUC5 genes is associated with early post-operative metastasis in non-small-cell lung cancer.
|
8980247 |
1996 |
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of MUC5 genes is associated with early post-operative metastasis in non-small-cell lung cancer.
|
8980247 |
1996 |
Cholestasis, Extrahepatic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In hepatolithiasis, MUC1, MUC2, and MUC5 apomucins were also focally expressed in 33%, 64%, and 89%, respectively, of the large intrahepatic bile ducts examined, whereas such expression was infrequent in normal livers and in extrahepatic biliary obstruction.
|
9425917 |
1998 |
Liver calculus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Increased expression of gel-forming mucins, such as MUC5 and MUC2, could be involved in the formation and development of hepatolithiasis.
|
9425917 |
1998 |
Cystic Fibrosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
No remarkable differences were observed in the expression patterns of MUC5B or MUC7 between CF (n = 7) and non-CF (n = 10) bronchial samples.
|
9651178 |
1998 |
Cystic Fibrosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We compared expression levels of three mucin genes, MUC1, MUC2, and MUC5/5AC, known to be expressed in the respiratory tract of CF, allergic rhinitis, and normal individuals.
|
9685530 |
1998 |
Crohn Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the expression levels of MUC3, MUC4, and MUC5B were significantly lower in both healthy and involved ileal mucosa of patients with Crohn's disease compared to controls (p < or = 0.05).
|
10028446 |
1999 |
Carcinogenesis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
In order to determine whether changes in D6-PR variant expression could occur during tumorigenesis, its expression was investigated by reverse transcription and polymerase chain reaction in ten normal reduction mammoplasty samples, nine breast tumours with high PR levels (> 100 fmol mg(-1) protein) and eight breast tumours with low PR levels (< 15 fmol mg(-1) protein), as determined by ligand binding assay.
|
10408841 |
1999 |
Mammary Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
In order to determine whether changes in D6-PR variant expression could occur during tumorigenesis, its expression was investigated by reverse transcription and polymerase chain reaction in ten normal reduction mammoplasty samples, nine breast tumours with high PR levels (> 100 fmol mg(-1) protein) and eight breast tumours with low PR levels (< 15 fmol mg(-1) protein), as determined by ligand binding assay.
|
10408841 |
1999 |
HER2 gene amplification
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We determined the amplification and overexpression of c-myc oncogene in 152 breast cancer patients and examined its prognostic value in relation to c-erbB-2 amplification and overexpression, high concentration of CD (> or = 60 pmol mg(-1) protein) and standard clinicopathological prognostic factors of the disease.
|
10604737 |
1999 |
Chronic otitis media
|
0.020 |
Biomarker
|
disease |
BEFREE |
Its expression was extensive in pseudostratified mucosal epithelia and related to infiltration of inflammatory cells in the submucosa of the middle ear cleft with COM, suggestive that inflammatory cell products are involved in the production of MUC5B.
|
10764016 |
2000 |
Stomach Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Aberrant expression of human mucin gene MUC5B in gastric carcinoma and cancer cells. Identification and regulation of a distal promoter.
|
11278696 |
2001 |
Otitis Media with Effusion
|
0.030 |
Biomarker
|
disease |
BEFREE |
MUC5B and MUC4 mucin genes were upregulated 4.2- and 6-fold, respectively, in middle ears with chronic otitis media (COM) or mucoid otitis media (MOM).
|
11350794 |
2001 |
Chronic otitis media
|
0.020 |
Biomarker
|
disease |
BEFREE |
MUC5B and MUC4 mucin genes were upregulated 4.2- and 6-fold, respectively, in middle ears with chronic otitis media (COM) or mucoid otitis media (MOM).
|
11350794 |
2001 |
Adenocarcinoma
|
0.030 |
AlteredExpression
|
group |
BEFREE |
MUC5AC and MUC5B expression is related to mucus formation in adenocarcinomas.
|
11578957 |
2001 |
airway disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
We therefore conclude that this newly cloned mouse Muc5b gene could be used as a marker for studying aberrant mucin gene expression in mouse models of various airway diseases.
|
11587997 |
2001 |
Carcinogenesis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
The 11p15 mucin genes (MUC2, MUC5AC, MUC5B and MUC6) possess a cell-specific pattern of expression in normal lung that is altered during carcinogenesis.
|
12077147 |
2002 |
Cystic Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Alterations in antibacterial peptide function, as well as the increased mucin expression and secretion (MUC 5AC and MUC 5B), are important biochemical factors responsible for the propensity for infection in CF airways.
|
12297057 |
2002 |
Otitis Media
|
0.020 |
Biomarker
|
disease |
LHGDN |
Expression of mucins in mucoid otitis media.
|
14690056 |
2003 |
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The loss of hormone dependence in this prostate cancer xenograft model is therefore marked by irreversible histological alterations, mucinous or neuro-endocrine, associated with an expression of secretory MUC2, MUC5B and MUC6, independent of the histological differentiation subtype.
|
14760390 |
2004 |
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The loss of hormone dependence in this prostate cancer xenograft model is therefore marked by irreversible histological alterations, mucinous or neuro-endocrine, associated with an expression of secretory MUC2, MUC5B and MUC6, independent of the histological differentiation subtype.
|
14760390 |
2004 |
Cystic Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that the vol/vol concentration of MUC5AC and MUC5B are decreased in the CF airways relative to normal mucus.
|
14988081 |
2004 |
Lung diseases
|
0.060 |
Biomarker
|
group |
BEFREE |
We then used antibodies to MUC5AC and MUC5B with Western gels and dot-blot to quantify mucin in sputum from 12 patients with CF and 11 subjects without lung disease.
|
14988081 |
2004 |
Chronic Obstructive Airway Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
Goblet cell hyperplasia and submucosal gland hypertrophy are shared with other hypersecretory diseases, such as chronic obstructive pulmonary disease; however, some features are different, including mucus plugging, mucus "tethering" to goblet cells, plasma exudation, and increased amounts of a low charge glycoform of mucin (MUC)5B and the presence of MUC2 in secretions.
|
15140415 |
2004 |
Mucus cast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Goblet cell hyperplasia and submucosal gland hypertrophy are shared with other hypersecretory diseases, such as chronic obstructive pulmonary disease; however, some features are different, including mucus plugging, mucus "tethering" to goblet cells, plasma exudation, and increased amounts of a low charge glycoform of mucin (MUC)5B and the presence of MUC2 in secretions.
|
15140415 |
2004 |