Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.040 AlteredExpression disease BEFREE Overexpression of MUC5 genes is associated with early post-operative metastasis in non-small-cell lung cancer. 8980247 1996
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.030 AlteredExpression phenotype BEFREE Overexpression of MUC5 genes is associated with early post-operative metastasis in non-small-cell lung cancer. 8980247 1996
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.100 AlteredExpression disease BEFREE No remarkable differences were observed in the expression patterns of MUC5B or MUC7 between CF (n = 7) and non-CF (n = 10) bronchial samples. 9651178 1998
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.100 AlteredExpression disease BEFREE We compared expression levels of three mucin genes, MUC1, MUC2, and MUC5/5AC, known to be expressed in the respiratory tract of CF, allergic rhinitis, and normal individuals. 9685530 1998
CUI: C0005398
Disease: Cholestasis, Extrahepatic
Cholestasis, Extrahepatic 		0.010 AlteredExpression disease BEFREE In hepatolithiasis, MUC1, MUC2, and MUC5 apomucins were also focally expressed in 33%, 64%, and 89%, respectively, of the large intrahepatic bile ducts examined, whereas such expression was infrequent in normal livers and in extrahepatic biliary obstruction. 9425917 1998
CUI: C0574143
Disease: Liver calculus
Liver calculus 		0.010 Biomarker disease BEFREE Increased expression of gel-forming mucins, such as MUC5 and MUC2, could be involved in the formation and development of hepatolithiasis. 9425917 1998
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.040 AlteredExpression phenotype BEFREE In order to determine whether changes in D6-PR variant expression could occur during tumorigenesis, its expression was investigated by reverse transcription and polymerase chain reaction in ten normal reduction mammoplasty samples, nine breast tumours with high PR levels (> 100 fmol mg(-1) protein) and eight breast tumours with low PR levels (< 15 fmol mg(-1) protein), as determined by ligand binding assay. 10408841 1999
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.020 AlteredExpression group BEFREE In order to determine whether changes in D6-PR variant expression could occur during tumorigenesis, its expression was investigated by reverse transcription and polymerase chain reaction in ten normal reduction mammoplasty samples, nine breast tumours with high PR levels (> 100 fmol mg(-1) protein) and eight breast tumours with low PR levels (< 15 fmol mg(-1) protein), as determined by ligand binding assay. 10408841 1999
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.010 AlteredExpression disease BEFREE Moreover, the expression levels of MUC3, MUC4, and MUC5B were significantly lower in both healthy and involved ileal mucosa of patients with Crohn's disease compared to controls (p < or = 0.05). 10028446 1999
CUI: C1512127
Disease: HER2 gene amplification
HER2 gene amplification 		0.010 AlteredExpression disease BEFREE We determined the amplification and overexpression of c-myc oncogene in 152 breast cancer patients and examined its prognostic value in relation to c-erbB-2 amplification and overexpression, high concentration of CD (> or = 60 pmol mg(-1) protein) and standard clinicopathological prognostic factors of the disease. 10604737 1999
CUI: C0271441
Disease: Chronic otitis media
Chronic otitis media 		0.020 Biomarker disease BEFREE Its expression was extensive in pseudostratified mucosal epithelia and related to infiltration of inflammatory cells in the submucosa of the middle ear cleft with COM, suggestive that inflammatory cell products are involved in the production of MUC5B. 10764016 2000
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.030 AlteredExpression group BEFREE MUC5AC and MUC5B expression is related to mucus formation in adenocarcinomas. 11578957 2001
CUI: C0029883
Disease: Otitis Media with Effusion
Otitis Media with Effusion 		0.030 Biomarker disease BEFREE MUC5B and MUC4 mucin genes were upregulated 4.2- and 6-fold, respectively, in middle ears with chronic otitis media (COM) or mucoid otitis media (MOM). 11350794 2001
CUI: C0699949
Disease: airway disease
airway disease 		0.030 Biomarker disease BEFREE We therefore conclude that this newly cloned mouse Muc5b gene could be used as a marker for studying aberrant mucin gene expression in mouse models of various airway diseases. 11587997 2001
CUI: C0271441
Disease: Chronic otitis media
Chronic otitis media 		0.020 Biomarker disease BEFREE MUC5B and MUC4 mucin genes were upregulated 4.2- and 6-fold, respectively, in middle ears with chronic otitis media (COM) or mucoid otitis media (MOM). 11350794 2001
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.010 AlteredExpression disease BEFREE Aberrant expression of human mucin gene MUC5B in gastric carcinoma and cancer cells. Identification and regulation of a distal promoter. 11278696 2001
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.100 Biomarker disease BEFREE Alterations in antibacterial peptide function, as well as the increased mucin expression and secretion (MUC 5AC and MUC 5B), are important biochemical factors responsible for the propensity for infection in CF airways. 12297057 2002
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.040 AlteredExpression phenotype BEFREE The 11p15 mucin genes (MUC2, MUC5AC, MUC5B and MUC6) possess a cell-specific pattern of expression in normal lung that is altered during carcinogenesis. 12077147 2002
CUI: C0029882
Disease: Otitis Media
Otitis Media 		0.020 Biomarker disease LHGDN Expression of mucins in mucoid otitis media. 14690056 2003
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.100 Biomarker disease BEFREE We conclude that the vol/vol concentration of MUC5AC and MUC5B are decreased in the CF airways relative to normal mucus. 14988081 2004
CUI: C0024115
Disease: Lung diseases
Lung diseases 		0.060 Biomarker group BEFREE We then used antibodies to MUC5AC and MUC5B with Western gels and dot-blot to quantify mucin in sputum from 12 patients with CF and 11 subjects without lung disease. 14988081 2004
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.050 AlteredExpression disease BEFREE COPD is specifically associated with increased expression of MUC5B in the bronchiolar lumen and of the mucin MUC5AC in the bronchiolar epithelium. 15500651 2004
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.050 Biomarker disease BEFREE Goblet cell hyperplasia and submucosal gland hypertrophy are shared with other hypersecretory diseases, such as chronic obstructive pulmonary disease; however, some features are different, including mucus plugging, mucus "tethering" to goblet cells, plasma exudation, and increased amounts of a low charge glycoform of mucin (MUC)5B and the presence of MUC2 in secretions. 15140415 2004
CUI: C0333133
Disease: Mucus cast
Mucus cast 		0.010 Biomarker disease BEFREE Goblet cell hyperplasia and submucosal gland hypertrophy are shared with other hypersecretory diseases, such as chronic obstructive pulmonary disease; however, some features are different, including mucus plugging, mucus "tethering" to goblet cells, plasma exudation, and increased amounts of a low charge glycoform of mucin (MUC)5B and the presence of MUC2 in secretions. 15140415 2004
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.010 AlteredExpression disease BEFREE The loss of hormone dependence in this prostate cancer xenograft model is therefore marked by irreversible histological alterations, mucinous or neuro-endocrine, associated with an expression of secretory MUC2, MUC5B and MUC6, independent of the histological differentiation subtype. 14760390 2004