ZNF750, zinc finger protein 750, 79755

N. diseases: 20; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.030 Biomarker group BEFREE Zinc-finger protein 750 (ZNF750) is the potential anti-cancer gene in oral squamous cell carcinoma (OSCC). 29416636 2018
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.030 Biomarker group BEFREE The present study is to explore the mechanism of ZNF750 to suppress the tumor malignant process by regulation tumor microenvironment. 29890464 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.030 GeneticVariation group BEFREE The Cancer Genome Atlas data further showed that ZNF750 genetic alterations were associated with early disease relapse. 28608921 2017
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.030 GeneticVariation group BEFREE The Cancer Genome Atlas data further showed that ZNF750 genetic alterations were associated with early disease relapse. 28608921 2017
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.030 GeneticVariation disease BEFREE We assessed the association of psoriasis and its main clinical phenotypes with common variants of three potential psoriasis susceptibility genes: ZNF750, RPTOR and TRAF31P2. 24005976 2014
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.030 AlteredExpression disease BEFREE Using a promoter functional assay in stimulated human primary keratinocytes, we showed that four ZNF750 promoter and 5' UTR variants displayed a 35-55% reduction of ZNF750 promoter activity, consistent with the promoter activity reduction seen in a Mendelian psoriasis family with a ZNF750 promoter variant. 22185198 2011
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.030 GeneticVariation disease BEFREE This report suggests that ZNF750 mutations could contribute to psoriasis susceptibility. 18256691 2008
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.030 GeneticVariation disease LHGDN This report suggests that ZNF750 mutations could contribute to psoriasis susceptibility. 18256691 2008
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.020 Biomarker phenotype BEFREE The aim of the present study was to investigate the clinical and prognostic significance of ZNF750 expression and to evaluate the effect of ZNF750 knockdown on cell proliferation, migration, and invasion in ESCC. 29216641 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.020 GeneticVariation phenotype BEFREE Combined analysis from current and previous genomic ESCC studies indicated more frequent ZNF750 mutation in diagnosed cases with LN metastasis than in those without metastasis (14% versus 3.4%, n = 629, P = 1.78 × 10<sup>-5</sup> ). 28608921 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.020 Biomarker phenotype BEFREE Taken together, these data suggest that ZNF750 may inhibit the metastasis of OSCC. 29113187 2017
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.020 Biomarker phenotype BEFREE Previous ESCC studies have demonstrated that ZNF750 knockdown strongly promotes proliferation, migration, and invasion. 28608921 2017
CUI: C0206684
Disease: Sebaceous Adenocarcinoma
Sebaceous Adenocarcinoma 		0.010 GeneticVariation disease BEFREE We show complete loss of the ZNF750 epidermal differentiation regulator in about half of ocular SeC, highlighting the most common genetic defect in this cancer type. 31148199 2019
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.010 Biomarker group BEFREE ZNF750 could modulate the tumor vascular microenvironment to inhibit the oral squamous cells carcinoma malignant progression. 29890464 2018
CUI: C0686619
Disease: Secondary malignant neoplasm of lymph node
Secondary malignant neoplasm of lymph node 		0.010 AlteredExpression disease BEFREE Low ZNF750 expression had a significant correlation with positive lymph node metastasis (p = 0.028). 29216641 2018
CUI: C2931822
Disease: Nasopharyngeal carcinoma
Nasopharyngeal carcinoma 		0.010 Biomarker disease BEFREE These findings uncovered the critical role of m<sup>6</sup>A in NPC, and stressed the regulatory function of the ZNF750-FGF14 signaling axis in modulating NPC progression, which provides theoretical guidance for the clinical treatment of NPC. 30518868 2018
CUI: C0751688
Disease: Malignant Squamous Cell Neoplasm
Malignant Squamous Cell Neoplasm 		0.010 Biomarker disease BEFREE Together, our findings characterize ZNF750 as a crucial SCC-specific suppressor and uncover its novel anticancer-associated functions. 27819679 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.010 GeneticVariation disease BEFREE To the best of our knowledge, our study is the first one that links TBCD and ZNF750 mutations to SCZ susceptibility and to the transcript levels in human brain tissues. 26728569 2016
CUI: C0406709
Disease: Hay-Wells syndrome
Hay-Wells syndrome 		0.010 Biomarker disease BEFREE Genomic profiling of a human organotypic model of AEC syndrome reveals ZNF750 as an essential downstream target of mutant TP63. 22922031 2012
CUI: C0262985
Disease: Psoriasiform eczema
Psoriasiform eczema 		0.010 GeneticVariation disease BEFREE Mutations in the ZNF750 promoter and coding regions have been previously associated with Mendelian forms of psoriasis and psoriasiform dermatitis. 22185198 2011