|
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Plasma and sputum IL-33, soluble ST2 (sST2) levels, and ST2L expression on eosinophils were measured in 10 healthy controls and 10 allergic asthmatics.
|
29694974 |
2018 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The critical function of IL-33/ST2 signaling in allergic inflammation is illustrated by the fact that IL33 and IL1RL1 are among the most highly replicated susceptibility loci for asthma.
|
29247993 |
2018 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the IL33 and IL1RL1 can act as protective or risk factors for asthma and/or allergy in humans.
|
28266165 |
2017 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
IL-33 is likely to play a critical role in asthma because the IL33 and ST2/IL1RL1 genes have been reproducibly identified as major susceptibility loci in large-scale genome-wide association studies.
|
25313073 |
2014 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We evidenced a new locus in the 16q12 region (near cylindromatosis turban tumor syndrome gene [CYLD]) and confirmed 4 asthma risk regions: 2q12 (IL-1 receptor-like 1 [IL1RL1]), 6p21 (HLA-DQA1), 9p24 (IL33), and 17q12-q21 (zona pellucida binding protein 2 [ZPBP2]-gasdermin A [GSDMA]).
|
27130862 |
2016 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This review describes the mechanisms through which genetic variation at the IL33 and IL1RL1 loci translates into increased susceptibility for asthma.
|
23380221 |
2013 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups.
|
21804549 |
2011 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Multimarker analysis identified TGFB1, IL1RL1, the gene encoding IL-18 receptor 1 (IL18R1), and DPP10 as the genes most significantly associated with asthma.
|
19910030 |
2010 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Serum IL-33 Level and IL-33, IL1RL1 Gene Polymorphisms in Asthma and Multiple Sclerosis Patients.
|
30950351 |
2019 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
TH2 pathway genes (IL13, TSLP, IL33, and IL1RL1) conferring asthma susceptibility were not associated with lung function.
|
23541324 |
2013 |
|
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Modulation of ILC2 function by miR-146a may depend on IL-33/interleukin 1 receptor-like 1 (IL1RL1 or ST2) signaling through inhibiting IRAK1 and TRAF6.miR-146a can inhibit IRAK1 and TRAF6, downstream molecules of ST2 signal pathway, thereby negatively regulate IL-33/ST2-activated ILC2 to inhibit asthma.
|
31435003 |
2020 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Four of these, GSDMB, IL33, RAD50 and IL1RL1, were previously reported as asthma susceptibility loci, but the effect sizes for these loci in our cohort were considerably larger than in the previous genome-wide association studies of asthma.
|
24241537 |
2014 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Accordingly, this study aimed to determine the associations of IL1RL1 rs3771180 and TSLP rs1837253 with asthma in Zhuang people.
|
31066119 |
2019 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Several genes in the TLR-related pathway were associated with atopy and/or asthma [e.g.IL1RL1, BPI, NOD1, NOD2 and MAP3K7IP1].
|
19968634 |
2010 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Clinical and genetic studies indicate that IL1RL1 plays an important role in the development and exacerbations of asthma.
|
22574108 |
2012 |
|
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Lung ST2L and toll-like receptor 9 protein expression levels concomitantly increased in a time-dependent manner during fungal asthma.
|
21640974 |
2011 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Common variants at IL33 and IL1RL1, encoding the IL-33 receptor ST2, associate with eosinophil counts and asthma.
|
28273074 |
2017 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
However, a variant in IL1RL1 that is in low linkage disequilibrium with that reported previously was associated with asthma risk after accounting for all variants tested (rs10197862, gene wide P = 0.01).
|
21150878 |
2011 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
This study aimed to characterize DNA methylation (DNA-me) in promoter region of IL33, IL1RL1 and CCL26 in asthma and their impacts on transcriptional activity in bronchial epithelial cells (BECs).
|
30468398 |
2018 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
We uncovered several promising tissue-specific regulatory TFs or genes for Alzheimer's disease (e.g.ZIC1 and STX1B) and asthma (e.g.CSF3 and IL1RL1).
|
29378629 |
2018 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genome-wide association studies have begun to identify genes underlying asthma (e.g., IL1RL1), which represent future therapeutic targets.
|
22455494 |
2012 |
|
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
IL1RL1-a levels negatively correlated with blood eosinophil counts, whereas there was no association between IL1RL1-a levels and asthma.In conclusion, asthma-associated <i>IL1RL1</i> SNPs strongly regulate <i>IL1RL1</i> methylation and serum IL1RL1-a levels, yet neither these <i>IL1RL1-</i>methylation CpG sites nor IL1RL1-a levels are associated with asthma.
|
29519908 |
2018 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Associations with variation in genes encoding the epithelial cell-derived cytokines, interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP), and the IL1RL1 gene encoding the IL-33 receptor, ST2, highlight the central roles for innate immune response pathways that promote the activation and differentiation of T-helper 2 cells in the pathogenesis of both asthma and allergic diseases.
|
21682736 |
2011 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus.
|
23028483 |
2012 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In 2 birth cohorts, the Prevalence and Incidence of Asthma and Mite Allergy (PIAMA) study and Avon Longitudinal Study of Parents and Children (ALSPAC), we analyzed associations of longitudinal wheezing phenotypes and asthma with single nucleotide polymorphisms (SNPs) of 8 genes encoding IL-33, IL1RL1, its coreceptor IL1RAcP, its adaptors myeloid differentiation primary response gene 88 (MyD88) and Toll-IL-11 receptor domain containing adaptor protein (TIRAP), and the downstream IL-1 receptor-associated kinase 1, IL-1 receptor-associated kinase 4, and TNF receptor-associated factor 6 (TRAF6).
|
24568840 |
2014 |