|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genome-wide association studies have begun to identify genes underlying asthma (e.g., IL1RL1), which represent future therapeutic targets.
|
22455494 |
2012 |
|
Asthma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
IL1RL1-a levels negatively correlated with blood eosinophil counts, whereas there was no association between IL1RL1-a levels and asthma.In conclusion, asthma-associated <i>IL1RL1</i> SNPs strongly regulate <i>IL1RL1</i> methylation and serum IL1RL1-a levels, yet neither these <i>IL1RL1-</i>methylation CpG sites nor IL1RL1-a levels are associated with asthma.
|
29519908 |
2018 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Associations with variation in genes encoding the epithelial cell-derived cytokines, interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP), and the IL1RL1 gene encoding the IL-33 receptor, ST2, highlight the central roles for innate immune response pathways that promote the activation and differentiation of T-helper 2 cells in the pathogenesis of both asthma and allergic diseases.
|
21682736 |
2011 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus.
|
23028483 |
2012 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In 2 birth cohorts, the Prevalence and Incidence of Asthma and Mite Allergy (PIAMA) study and Avon Longitudinal Study of Parents and Children (ALSPAC), we analyzed associations of longitudinal wheezing phenotypes and asthma with single nucleotide polymorphisms (SNPs) of 8 genes encoding IL-33, IL1RL1, its coreceptor IL1RAcP, its adaptors myeloid differentiation primary response gene 88 (MyD88) and Toll-IL-11 receptor domain containing adaptor protein (TIRAP), and the downstream IL-1 receptor-associated kinase 1, IL-1 receptor-associated kinase 4, and TNF receptor-associated factor 6 (TRAF6).
|
24568840 |
2014 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
CTD_human |
Four of these, GSDMB, IL33, RAD50 and IL1RL1, were previously reported as asthma susceptibility loci, but the effect sizes for these loci in our cohort were considerably larger than in the previous genome-wide association studies of asthma.
|
24241537 |
2014 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
CTD_human |
Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups.
|
21804549 |
2011 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
CTD_human |
IL-33 Drives Augmented Responses to Ozone in Obese Mice.
|
27472835 |
2017 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
CTD_human |
A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls).
|
19198610 |
2009 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
CTD_human |
However, a variant in IL1RL1 that is in low linkage disequilibrium with that reported previously was associated with asthma risk after accounting for all variants tested (rs10197862, gene wide P = 0.01).
|
21150878 |
2011 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Identification of a new locus at 16q12 associated with time to asthma onset.
|
27130862 |
2016 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.
|
30552067 |
2019 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.
|
31619474 |
2019 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
|
24388013 |
2014 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
|
30929738 |
2019 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases.
|
29785011 |
2018 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups.
|
21804549 |
2011 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.
|
31036433 |
2019 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.
|
23028483 |
2012 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
|
29273806 |
2018 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Large-scale, multiethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults.
|
30578877 |
2019 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
LHGDN |
Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopy.
|
18774397 |
2008 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.
|
23028483 |
2012 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups.
|
21804549 |
2011 |