|
Fibromyalgia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Asic3<sup>-/-</sup> mice were impaired in only muscle allodynia development but not other pain symptoms in the ICS model, so the ASIC3-dependent metabolomics changes could be useful for developing diagnostic biomarkers specific to chronic widespread muscle pain, the core symptom of FM.
|
31431652 |
2019 |
|
Hyperalgesia
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Therefore, this study investigated the effect of NGF on ASIC3 expression in the TNC and the role of NGF signaling in chemical dural stimulation-induced hyperalgesia.
|
30553789 |
2019 |
|
Fibromyalgia
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
ASIC3, Nav1.7 and Nav1.8 protein levels increased significantly in both the dorsal root ganglion and in the spinal cord of FM model mice.
|
29343477 |
2018 |
|
Hyperalgesia
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
We have previously shown ASIC3 is important in activity-induced hyperalgesia.
|
29964154 |
2018 |
|
Fibromyalgia
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Nociceptive receptors, such as ASIC3, Nav1.7, and Nav1.8, were upregulated in the dorsal root ganglion (DRG) and spinal cord (SC) of FM mice.
|
28440280 |
2017 |
|
Fibromyalgia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Patients with CFS with comorbid fibromyalgia (n = 18) also showed greater increases in acid-sensing ion channel 3 and purinergic type 2X5 receptors (p < .05).
|
22210239 |
2012 |
|
Hyperalgesia
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Both APETx2 and the in vivo knockdown of ASIC3 with a specific siRNA also have potent analgesic effects against primary inflammation-induced hyperalgesia in rat.
|
18923424 |
2008 |
|
Intervertebral Disc Degeneration
|
0.030 |
Biomarker
|
disease |
BEFREE |
The distribution of ASICs in NP, EP, annulus fibrosus, and the particular functions of ASIC1a and ASIC3 remind us about the pathological significance of ASICs in IVDD, which could be a promising therapeutic target in future treatment for IVDD.
|
31526163 |
2019 |
|
Myalgia
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Asic3<sup>-/-</sup> mice were impaired in only muscle allodynia development but not other pain symptoms in the ICS model, so the ASIC3-dependent metabolomics changes could be useful for developing diagnostic biomarkers specific to chronic widespread muscle pain, the core symptom of FM.
|
31431652 |
2019 |
|
Rheumatoid Arthritis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Accordingly, a number of selective as well as nonselective ASIC3 inhibitors have shown potential in attenuating pain and inflammation in animal models of rheumatoid arthritis.
|
30035658 |
2018 |
|
Inflammatory pain
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Its peripheral analgesic activity was then assessed relative to APETx2, an ASIC3 inhibitor, and morphine, in a Freund's complete adjuvant (FCA)-induced rat model of inflammatory pain.
|
29134638 |
2018 |
|
Rheumatoid Arthritis
|
0.030 |
Biomarker
|
disease |
BEFREE |
TDAG8 likely participates in the initiation of RA pain, but all three genes, TDAG8, TRPV1, and ASIC3, are essential to establish hyperalgesic priming to regulate the chronic phase of RA pain.
|
28827659 |
2017 |
|
Intervertebral Disc Degeneration
|
0.030 |
Biomarker
|
disease |
BEFREE |
In conclusion, these results suggested that NF‑κB and ASIC3 may serve an important role in intervertebral disc degeneration caused by NP.
|
28765874 |
2017 |
|
Myalgia
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, injection of the peptide into the gastrocnemius muscle strongly enhanced acid-induced muscle pain in mice that was abolished by genetic inactivation of ASIC3.
|
28396446 |
2017 |
|
Intervertebral Disc Degeneration
|
0.030 |
Biomarker
|
disease |
BEFREE |
Acidic pH promotes intervertebral disc degeneration: Acid-sensing ion channel -3 as a potential therapeutic target.
|
27853274 |
2016 |
|
Rheumatoid Arthritis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Experiments were performed in cultured FLS from wild-type (WT) and ASIC3-/- mice, ASIC1-/- mice, and people with rheumatoid arthritis.
|
24923411 |
2014 |
|
Inflammatory pain
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Together, these data identify ASIC3 channels as an unexpected molecular target for acute actions of 5-HT in inflammatory pain sensation and reveal an important role of ASIC3 channels in regulating inflammatory pain via coincident detection of extracellular protons and inflammatory mediators.
|
23467344 |
2013 |
|
Myalgia
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
We recently demonstrated that acid sensing ion channel (probably ASIC3), purinergic type 2X receptors (probably P2X4 and P2X5) and the transient receptor potential vanilloid type 1 (TRPV1) are molecular receptors in mouse sensory neurons detecting metabolites that cause acute muscle pain and possibly muscle fatigue.
|
19647494 |
2009 |
|
Inflammatory pain
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
ASIC3, a sensor of acidic and primary inflammatory pain.
|
18923424 |
2008 |
|
Migraine Disorders
|
0.020 |
Biomarker
|
group |
BEFREE |
Our previous study showed that acid-sensing ion channel 3 (ASIC3) in the trigeminal nucleus caudalis (TNC) is involved in the pathogenesis of recurrent migraine.
|
30553789 |
2019 |
|
Arthritis
|
0.020 |
Biomarker
|
disease |
BEFREE |
The present review discusses the dual nature of ASIC3 in joint inflammation with possible mechanisms.
|
30035658 |
2018 |
|
Migraine Disorders
|
0.020 |
Biomarker
|
group |
BEFREE |
Recent studies have indicated that ASIC3 in the peripheral trigeminal ganglia is likely involved in the pathogenesis of migraine pain.
|
30209688 |
2018 |
|
Mechanical Allodynia
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
To create a mouse model of FM pain using dual injections of acidic saline to cause mechanical hyperalgesia and test whether ASIC3, Nav1.7 and Nav1.8 are involved in this process and whether electroacupuncture (EA) can reverse these phenomena.
|
29343477 |
2018 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Furthermore, they present a mechanistic rationale for targeting ASIC3 on neurons along with the multiple myeloma-induced acidic bone microenvironment as a strategy to relieve MMBP in patients.<i>Cancer Res; 77(6); 1283-95.©2017 AACR</i>.
|
28254863 |
2017 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Glioblastoma cancer stem cell lines express functional acid sensing ion channels ASIC1a and ASIC3.
|
29057936 |
2017 |