|
Carcinogenesis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
SCD5, SPTBN1, FABP5, SQLE, PTPLA (HACD1), and CDC25B transcription levels were of high prognostic value, which might assist us to understand the underlying carcinogenesis or advancement of UVM better.
|
31270856 |
2019 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Collectively, our study demonstrate that KCTD12 binds to CDC25B and activates CDK1 and Aurora A to facilitate the G2/M transition and promote tumorigenesis and that Aurora A phosphorylates KCTD12 at serine 243 to trigger a positive feedback loop, thereby potentiating the effects of KCTD12.
|
28869606 |
2017 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
In the tumor initiation, the opposite role of YWHAE and CDC25B in gastric carcinogenesis seems to be independent of MYC expression.
|
27863420 |
2016 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Both CDC25B and PED/PEA-15 play a certain role in the carcinogenesis of esophageal cancer, and PED/PEA-15 has a greater influence on postoperative survival time.
|
25775393 |
2015 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
CDC25B is a cell-cycle regulatory protein, which is considered to be related to tumorigenesis and progression of tumours.
|
16803948 |
2006 |
|
Carcinogenesis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
We postulate that the induction of Cdc25B expression in lung cancer cells by the ultimate carcinogen anti-BPDE accelerates the further development of lung carcinogenesis.
|
12591724 |
2003 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Moreover, we demonstrated that miR-214 inhibited Eca9706 and Eca109 cells proliferation and invasion through CDC25B.
|
28954387 |
2017 |
|
Tumor Cell Invasion
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
Expression of CDC25A and CDC25B showed significant correlation with poor tumour differentiation and tumour invasion (p<0.05).
|
25326518 |
2015 |
|
Tumor Cell Invasion
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
The CDC25B protein expression was correlated with differentiation grade and depth of invasion (p<0.05).
|
25775393 |
2015 |
|
Tumor Cell Invasion
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
For the first time, we demonstrate that miRNA-211 is a direct negative regulator of CDC25B expression in TNBC cells, alters other related target proteins CCNB1 and FOXM1, and then inhibits breast cancer cells growth, migration, and invasion and lead G2/M arrest.
|
25680404 |
2015 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
CDC25A (+), as well as CDC25B (+), was more frequently found in patients with deeper tumour invasion and lymph node metastasis, while tumour size was correlated only with CDC25A expression.
|
11487274 |
2001 |
|
Tumor Cell Invasion
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
Strong expression of CDC25B protein was associated with advanced stage and deep invasion.
|
9414655 |
1997 |
|
Squamous cell carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
CDC25B was primarily cytoplasmic in skin and skin tumors and was significantly increased in the squamous cell carcinoma (SCC), while CDC25C was mostly nuclear in the skin, with an increased cytoplasmic signal in the premalignant and malignant tumors.
|
31237025 |
2019 |
|
Squamous cell carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of CDC25B and LAMC2 mRNA and protein in esophageal squamous cell carcinomas and premalignant lesions in subjects from a high-risk population in China.
|
18559558 |
2008 |
|
Squamous cell carcinoma
|
0.040 |
AlteredExpression
|
disease |
LHGDN |
Overexpression of CDC25B and LAMC2 mRNA and protein in esophageal squamous cell carcinomas and premalignant lesions in subjects from a high-risk population in China.
|
18559558 |
2008 |
|
Squamous cell carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
To identify pretreatment markers predicting response and survival, we examined the expression of cell cycle regulatory molecules, p53, p21(Waf1/Cip1) cyclin D1, and CDC25B, in biopsy specimens from 76 patients with stage III and stage IV squamous cell carcinoma.
|
15569370 |
2004 |
|
Squamous cell carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Clinical significance of CDC25A and CDC25B expression in squamous cell carcinomas of the oesophagus.
|
11487274 |
2001 |
|
Liver carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
SNHG16 as the miRNA let-7b-5p sponge facilitates the G2/M and epithelial-mesenchymal transition by regulating CDC25B and HMGA2 expression in hepatocellular carcinoma.
|
31696971 |
2020 |
|
Esophageal carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Low expression of (or IHC-negative) COX2, miR-200c, ERCC1 and TS, or high expression of (or IHC-positive) CDC25B and p16 are potential biomarkers for predicting the response of esophageal cancer patients treated with chemo(radio)therapy.
|
29113666 |
2017 |
|
Esophageal carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Fluorescence quantitative real-time PCR and immunohistochemistry methods were used to analyze the expression of CDC25B, PED/PEA-15 in esophageal carcinoma.
|
25775393 |
2015 |
|
Liver carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The mechanism of resistance to HCC development is associated with nuclear accumulation of the cell cycle inhibitor p27(Kip1) protein and reduced expression of the Cdk1-activator Cdc25B phosphatase.
|
15082532 |
2004 |
|
Liver carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry of 59 HCCs showed marked increase in CDC25A expression, but not CDC25B, in HCC compared with noncancer tissues, and high expression of CDC25A in 33 of 59 (56%) HCCs.
|
12738732 |
2003 |
|
Esophageal carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In this study, we investigated the effect of CDC25B overexpression on radiation-induced G2-M arrest and radiation sensitivity in esophageal cancer cells.
|
11306507 |
2001 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
CDC25B was primarily cytoplasmic in skin and skin tumors and was significantly increased in the squamous cell carcinoma (SCC), while CDC25C was mostly nuclear in the skin, with an increased cytoplasmic signal in the premalignant and malignant tumors.
|
31237025 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.020 |
Biomarker
|
disease |
BEFREE |
The rate of positive cytoplasmic staining of cyclin B1 and positive nuclear staining of both CDC25B and CDC25C increased with increase in tumor grade and lymph node metastasis.
|
30487595 |
2019 |