Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Analysis of HDGC patients harbouring CDH1 alleles with PTCs at a wide variety of different positions indicates an association of their predicted ability to induce NMD and an earlier age of onset of gastric cancer.
|
18427545 |
2008 |
Stomach Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
E-cadherin genetic screening and clinico-pathologic characteristics of early onset gastric cancer.
|
21106365 |
2011 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Probands from two Danish families with gastric cancer and a history suggesting HDGC were screened for CDH1 gene mutations.
|
24389957 |
2014 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
CDH1 -160 -AA genotype was associated with an increased risk of GC (OR = 3.6, 95% CI: 1.1-11.8) (P = 0.03).
|
20632448 |
2010 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
E-cadherin/CDH1 gene methylation is an important cause for its gene silence in diffuse variant gastric carcinoma.
|
16830381 |
2006 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Germline CDH1 mutations recently were identified in families with hereditary diffuse gastric carcinoma in a pattern suggestive of autosomal dominant inheritance with incomplete penetrance.
|
11443625 |
2001 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The majority of patients with germline CDH1 mutation have foci of noninvasive or invasive gastric cancer by middle age.
|
20719348 |
2011 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In meta-analysis, CDH1 -160C>A showed an inverse association with GC among Asians (OR, 0.76; 95% CI, 0.55-1.05) and a positive association among Caucasians (OR, 1.40; 95% CI, 0.95-2.04).
|
18544073 |
2008 |
Stomach Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
A great number of genes with promoter methylation have been observed in gastric cancer (GC), among which p16INK4A (p16), Mut L homologue 1 (MLH1), Epithelial-cadherin (E-cadherin), Runt-related transcription factor 3 (RUNX3), adenomatous polyposis coli (APC), O(6)-methylguanine-DNA methyltransferase (MGMT), Ras association domain family 1A (RASSF1A) and Death-associated protein kinase (DAPK) have been extensively studied.
|
22936446 |
2012 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: a case control study in an Italian population.
|
18482459 |
2008 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: from the laboratory to clinical practice.
|
14630673 |
2003 |
Stomach Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The E-cadherin protein expression level in gastric cancer tissues was significantly lower than that in the adjacent normal tissues (p < 0.05).
|
22581441 |
2012 |
Stomach Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
CDH1a, a non-canonical transcript of the CDH1 gene, has been found to be expressed in some gastric cancer (GC) cell lines, whereas it is absent in normal gastric mucosa.
|
29443099 |
2018 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms of the E-cadherin promoter and risk of sporadic gastric carcinoma in Chinese populations.
|
18768510 |
2008 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
However, three CDH1 polymorphisms in the same haplotype block, including the CDH1-160C/A, interacted with smoking to increase GC risk in smokers but not in never smokers.
|
18342503 |
2008 |
Stomach Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Ectopic expression of circFNDC3B reduced the level of E-cadherin protein to promote the epithelial-mesenchymal transition in GC.
|
30963578 |
2019 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This study evaluated the effect of PTG on health-related quality of life (HRQL) in asymptomatic individuals with identified CDH1 mutations at high risk for gastric cancer.
|
24424140 |
2014 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this meta-analysis suggests that CDH1 -160 A-allele may play a protective role of stomach cancer development in Asians but not in Caucasians.
|
21625863 |
2012 |
Stomach Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
For the first time, we evaluated by digital PCR the expression of CDH1 and CDH1a transcripts in cancer and normal tissue samples from 32 patients with intestinal-type gastric cancer.
|
27861150 |
2017 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
CDH1 somatic alterations were found in approximately 30% of all patients with GC.
|
23341533 |
2013 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To examine the frequency of CDH1 germline mutations in a population-based series of early-onset gastric cancer (EOGC <50 years old).
|
16801346 |
2006 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the CDH1 gene are linked both to diffuse gastric cancer and invasive lobular carcinoma (ILC).
|
28993866 |
2018 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the ATCTG and CTTTG CDH1 haplotypes may be associated with an increased risk and decreased risk, respectively, of GC in the Japanese population.
|
17852867 |
2007 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This study was aimed to analyse the hypermethylation status of the E-Cadherin (CDH1) gene promoter in GCs in the ethnic Kashmiri population.
|
27356686 |
2016 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To our knowledge, this is the first Korean case of presymptomatic detection of CDH1 mutation, and it highlights the importance of genetic screening for individuals with a family history of GC, especially in high-risk geographical areas.
|
25187893 |
2014 |