Stomach Carcinoma
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
Stomach Carcinoma
|
0.700 |
CausalMutation
|
disease |
CGI |
|
|
|
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
E-cadherin gene mutations have previously been detected in advanced diffuse-type gastric cancer and gastric carcinoma cell lines.
|
8973475 |
1996 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Familial gastric cancer is genetically heterogeneous and it is not clear what proportion of gastric cancer susceptibility in non-Maori populations is due to germline CDH1 mutations.
|
10072428 |
1999 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Characterization of a mutant E-cadherin protein encoded by a mutant gene frequently seen in diffuse-type human gastric carcinoma.
|
11058874 |
2000 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Germline CDH1 mutations recently were identified in families with hereditary diffuse gastric carcinoma in a pattern suggestive of autosomal dominant inheritance with incomplete penetrance.
|
11443625 |
2001 |
Stomach Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our results suggest that the mRNA expression levels for pro-methylating (DNMT1, DNMT3a, DNMT3b) and anti-methylating (MBD2) enzymes is not a critical determinate of tumor-specific promoter hypermethylation of hMLH1, p(16INK4a), or CDH1 in gastric carcinoma.
|
11496321 |
2001 |
Stomach Carcinoma
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma.
|
11313896 |
2001 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
No truncating or splice site CDH1 mutations were identified by PCR single-strand conformational polymorphism in these families or in eight individual patients who had both prostate and gastric cancer.
|
11705864 |
2001 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Incidence of gastric cancer and breast cancer in CDH1 (E-cadherin) mutation carriers from hereditary diffuse gastric cancer families.
|
11729114 |
2001 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Inactivation of the E-cadherin gene in sporadic diffuse-type gastric cancer.
|
11598162 |
2001 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Heterozygotes with the CDH1 mutation have a 70-80% chance of developing gastric cancer and once patients have invasive, symptomatic disease there is a high associated morbidity and mortality.
|
12145417 |
2002 |
Stomach Carcinoma
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
These results suggest that at least two types of promoter methylation status are involved in the development of the intestinal (p16(INK4a) promoter hypermethylation) and diffuse-scattered types (CDH1 and RAR-beta promoter hypermethylation) of gastric carcinoma.
|
12210063 |
2002 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association of CDH1 haplotypes with susceptibility to sporadic diffuse gastric cancer.
|
12444556 |
2002 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
It is estimated that 25% of families meeting the criteria for hereditary diffuse gastric carcinoma (HDCG) will have germline mutations in the E-cadherin gene.
|
12373604 |
2002 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The mutation to the E-cadherin gene has high penetrance and confers a lifetime risk of gastric cancer of 80% for carriers.
|
11998610 |
2002 |
Stomach Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Cell adhesion molecule abnormalities such as those involving CDH1 may play an important role in diffuse-type gastric cancer development.
|
11979414 |
2002 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
E-cadherin gene variants in gastric cancer families whose probands are diagnosed with diffuse gastric cancer.
|
12216071 |
2002 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
CDH1 c-160a promotor polymorphism is not associated with risk of stomach cancer.
|
12209998 |
2002 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Here we report the results of germline CDH1 mutation screening in 39 kindred with familial aggregation of gastric cancer, a subset of which fulfills the criteria defined by the IGCLC for HDGC.
|
11968083 |
2002 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: from the laboratory to clinical practice.
|
14630673 |
2003 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The novel CDH1 nucleotide change is uncommon in Italian patients with sporadic diffuse gastric cancer.
|
14610318 |
2003 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Correlation of a single nucleotide polymorphism in the E-cadherin gene promoter with tumorigenesis and progression of gastric carcinoma in Japan.
|
12851691 |
2003 |