Stomach Carcinoma
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
Stomach Carcinoma
|
0.700 |
CausalMutation
|
disease |
CGI |
|
|
|
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
Stomach Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
59 GCs, 59 first degree relatives (FDRs) of GC, 20 autoimmune metaplastic atrophic gastritis (AMAGs) and 52 blood donors (BDs) were analyzed for CDH1 by direct sequencing, structural modelling and bioinformatics.
|
24204729 |
2013 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Gastric cancer (GC) is considered to be one of the leading cancers in East Asians, and mutations in the CDH1 gene and the reduced expression of E-cadherin are the most frequent genetic alterations in gastric cancer.
|
23435907 |
2013 |
Stomach Carcinoma
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma.
|
11313896 |
2001 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
CDH1 c-160a promotor polymorphism is not associated with risk of stomach cancer.
|
12209998 |
2002 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
E-cadherin gene variants in gastric cancer families whose probands are diagnosed with diffuse gastric cancer.
|
12216071 |
2002 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
CDH1 gene germline mutation is common in many types of carcinoma, and occurs very frequent in hereditary gastric carcinoma (HGC) patients and their families.
|
15457549 |
2004 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
E-cadherin gene C-160A promoter polymorphism may not play a major role in the etiology of non-cardia gastric cancer in Chinese population.
|
15609397 |
2005 |
Stomach Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
CDH1 associated gastric cancer: a report of a family and review of the literature.
|
15780560 |
2005 |
Stomach Carcinoma
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
CDH1 gene promoter hypermethylation in gastric cancer: relationship to Goseki grading, microsatellite instability status, and EBV invasion.
|
16531765 |
2006 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
CDH1 mutations in individuals from families with HDGC are associated with gastric cancer in a highly penetrant fashion.
|
17522512 |
2007 |
Stomach Carcinoma
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
E-cadherin promoter hypermethylation induced by interleukin-1beta treatment or H. pylori infection in human gastric cancer cell lines.
|
18249489 |
2008 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
CDH1 C-160A promoter polymorphism and gastric cancer risk.
|
19077564 |
2009 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
CDH1 -160 -AA genotype was associated with an increased risk of GC (OR = 3.6, 95% CI: 1.1-11.8) (P = 0.03).
|
20632448 |
2010 |
Stomach Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
E-cadherin genetic screening and clinico-pathologic characteristics of early onset gastric cancer.
|
21106365 |
2011 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
CDH1 mutation carriers have a strongly increased risk of developing gastric cancer (GC) and lobular breast cancer (LBC).
|
22020549 |
2012 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
CDH1 mutation testing in families with a history of gastric cancer and prophylactic gastrectomy in mutation-positive patients are recommended for the management of HDGC.
|
22160243 |
2012 |
Stomach Carcinoma
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
CDH1 methylation in preoperative peritoneal washes is an independent prognostic factor for gastric cancer.
|
22514028 |
2012 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
CDH1 somatic alterations were found in approximately 30% of all patients with GC.
|
23341533 |
2013 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
CDH1 germ-line missense mutation identified by multigene sequencing in a family with no history of diffuse gastric cancer.
|
25981591 |
2015 |
Stomach Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
CDH1 was downregulated in diffuse-type GC tissues (P=0.0007) and showed a negative relationship with HOTAIR (r(2)=0.154, P=0.0354).
|
26136075 |
2015 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
CDH1 somatic alterations in Mexican patients with diffuse and mixed sporadic gastric cancer.
|
30642281 |
2019 |