|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Some signet ring cell carcinomas have been found to have mutations in the E-cadherin gene, which fits the above hypothesis.
|
25019985 |
2014 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our study provides strong in vivo evidence that E-cadherin gene mutations may contribute to the development of diffusely growing gastric carcinomas and support a tumor/metastasis suppressor gene hypothesis.
|
8033105 |
1994 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In diffuse gastric carcinomas harboring CDH1 mutations, LOH was observed in a single case.
|
11313896 |
2001 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A comprehensive search using the keywords "CDH1," "E-Cadherin," "polymorphism," "SNP," and "variant" combined with "breast," "cancer," "tumor," or "carcinomas" was conducted.
|
27349965 |
2016 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Endoscopic screening in HDGC families without a pathogenic CDH1 mutation may be reasonable, as we detected signet ring cell carcinomas in 6% of persons screened.
|
28455161 |
2018 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Ongoing research focus on the search of genetic causes other than CDH1 or CTNNA1 germline defects; assessment of the pathogenicity and penetrance of CDH1 missense mutations and identification of somatic mechanisms behind the progression from early (indolent) lesions to invasive (lethal) carcinomas.
|
25439071 |
2014 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Distinct pattern of allelic loss and inactivation of cadherin 1 and 5 genes in mammary carcinomas arising in p53(+/-) mice.
|
17327688 |
2007 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
As TP53 mutation and CDH1 inactivation occur in 80% of human endometrial type II carcinomas, we hypothesized that mouse uteri lacking both Trp53 and Cdh1 would exhibit a phenotype indicative of neoplastic transformation.
|
24998851 |
2015 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Mutations in the epithelial cadherin (E-cadherin) gene have been shown to be associated with the occurrence of diffuse gastric carcinomas in affected families.
|
17609302 |
2007 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The utility of this technique is demonstrated by PCR amplification and sequencing of the E-cadherin gene, which codes for a homophilic cell-to-cell adhesion molecule, in early gastric carcinomas of the diffuse type of Lauren's classification.
|
9387937 |
1998 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Alterations of the E (epithelial)-cadherin gene are often involved in undifferentiated-type carcinomas of the stomach, but not in the differentiated type.
|
10547575 |
1999 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Hypermethylation in the CDH1 promoter region is a frequent phenomenon in poorly differentiated, diffuse gastric carcinomas and it was identified as the main mechanism for the inactivation of the remaining wild-type allele in HDGC cases.
|
14630673 |
2003 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
CDH1 germline mutations lead to hereditary diffuse gastric carcinomas.
|
29168119 |
2018 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We found mutations of the E-cadherin gene in 7 of 10 "pure" diffuse carcinomas (70.0%) and in 5 of 6 mixed carcinomas (83.3%).
|
10211998 |
1999 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Association of CDH1 single nucleotide polymorphisms with susceptibility to esophageal squamous cell carcinomas and gastric cardia carcinomas.
|
18197935 |
2008 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Using whole-exome and targeted sequencing, we find that truncating somatic alterations in the CDH1 gene occur in 84% of plasmacytoid carcinomas and are specific to this histologic variant.
|
26901067 |
2016 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Synchronous appendiceal and intramucosal gastric signet ring cell carcinomas in an individual with CDH1-associated hereditary diffuse gastric carcinoma: a case report of a novel association and review of the literature.
|
23849133 |
2013 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Large numbers of stage T1a signet ring cell carcinomas exist in the stomachs of CDH1 mutation carriers from a young age, and these foci sometimes show enrichment to the transition zone between the body and antrum.
|
19432899 |
2009 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Epithelial cadherin (E-cadherin) gene and protein alterations are implicated in the existence of two clearly distinct types of tumors in the stomach (isolated cell and glandular carcinomas), breast (lobular and ductal carcinomas), and thyroid (papillary and follicular carcinomas), as well as in the occurrence of poorly differentiated foci in colorectal and prostate adenocarcinomas.
|
12409641 |
2002 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We show that a proportion of apparently sporadic early-onset diffuse gastric carcinomas are associated with germline alterations of the E-cadherin gene.
|
12588804 |
2003 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Promoter hypermethylation of hMLH1, p16(INK4a), and CDH1 was detected in 5/20 (25%), 8/20 (40%) and 8/20 (40%) of gastric carcinomas, respectively.
|
11496321 |
2001 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
CTD_human |
Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas.
|
16316942 |
2005 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
We found high epithelial marker expressions (CK8/18, E-cadherin, membranous β-catenin) only in a distinct variety of carcinomas.
|
27729431 |
2017 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
CTD_human |
Promoter methylation as a common mechanism for inactivating E-cadherin in human salivary gland adenoid cystic carcinoma.
|
17520682 |
2007 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
This study was conducted to evaluate the promoter methylation status of p16(INK4a) and E-cadherin genes in 22 specimens of cervical carcinomas, four cervical cancer cell lines (HeLa, SiHa, Caski, C33A), and 20 human papillomavirus negative specimens, obtained from normal cervical swabs, using the methylation-specific PCR approach.
|
20112504 |
2009 |