|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Epithelial cadherin (E-cadherin) gene and protein alterations are implicated in the existence of two clearly distinct types of tumors in the stomach (isolated cell and glandular carcinomas), breast (lobular and ductal carcinomas), and thyroid (papillary and follicular carcinomas), as well as in the occurrence of poorly differentiated foci in colorectal and prostate adenocarcinomas.
|
12409641 |
2002 |
|
Carcinoma
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
CDH1 promoter hypermethylation was found in 20 out of 70 gastric carcinomas and the epigenetic change occurred in the early, as well as in the locally advanced disease.
|
14998854 |
2004 |
|
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Cadherin-1 (CHD1), as an invasion suppressor gene, could suppress tumor cell invasion and metastasis in various tumors, but reduced CHD1 levels, resulting from epigenetic silencing, are common in poorly differentiated, advanced stage carcinomas.
|
24952891 |
2014 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Epithelial-cadherin (Ecad) deregulation affects cell-cell adhesion and results in increased invasiveness of distinct human carcinomas.
|
26246502 |
2015 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
CDH1 germline mutations lead to hereditary diffuse gastric carcinomas.
|
29168119 |
2018 |
|
Carcinoma
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
Epithelial cadherin (E-cadherin) is a classic tumor suppressor gene of the cadherin superfamily and its promoter region is usually hypermethylated in malignant carcinomas.
|
30390382 |
2019 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A comprehensive search using the keywords "CDH1," "E-Cadherin," "polymorphism," "SNP," and "variant" combined with "breast," "cancer," "tumor," or "carcinomas" was conducted.
|
27349965 |
2016 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Alterations of the E (epithelial)-cadherin gene are often involved in undifferentiated-type carcinomas of the stomach, but not in the differentiated type.
|
10547575 |
1999 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
As TP53 mutation and CDH1 inactivation occur in 80% of human endometrial type II carcinomas, we hypothesized that mouse uteri lacking both Trp53 and Cdh1 would exhibit a phenotype indicative of neoplastic transformation.
|
24998851 |
2015 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Association of CDH1 single nucleotide polymorphisms with susceptibility to esophageal squamous cell carcinomas and gastric cardia carcinomas.
|
18197935 |
2008 |
|
Carcinoma
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
By MSP, nearly all of the carcinomas showed aberrant methylation of E-cadherin promoter in EBVaGC (21/22), and the frequency of this aberration was significantly higher than that in EBV-negative gastric carcinoma (GC; 45/81; p = 0.0003).
|
14750169 |
2004 |
|
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Disruption of E-cadherin (CDH1 gene) expression, subcellular localization or function arises during initiation and progression of almost 90% of all epithelial carcinomas.
|
22752307 |
2012 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Distinct pattern of allelic loss and inactivation of cadherin 1 and 5 genes in mammary carcinomas arising in p53(+/-) mice.
|
17327688 |
2007 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Endoscopic screening in HDGC families without a pathogenic CDH1 mutation may be reasonable, as we detected signet ring cell carcinomas in 6% of persons screened.
|
28455161 |
2018 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Expression of the nuclear factor ZEB1 induces an epithelial-to-mesenchymal transition and confers a metastatic phenotype on carcinomas by repressing the E-cadherin gene at the transcriptional level.
|
20418909 |
2010 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
CTD_human |
Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas.
|
16316942 |
2005 |
|
Carcinoma
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
Helicobacter pylori infection in relation to E-cadherin gene promoter polymorphism and hypermethylation in sporadic gastric carcinomas.
|
16127748 |
2005 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Hypermethylation in the CDH1 promoter region is a frequent phenomenon in poorly differentiated, diffuse gastric carcinomas and it was identified as the main mechanism for the inactivation of the remaining wild-type allele in HDGC cases.
|
14630673 |
2003 |
|
Carcinoma
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
Hypermethylation of the E-cadherin promoter was evident in 27 (51%) of 53 primary gastric carcinomas examined by MSP-SSCP.
|
10749913 |
2000 |
|
Carcinoma
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
In agreement with previous work demonstrating that somatic mutations and loss of heterozygosity of the E-cadherin gene are rare or absent in the majority of SCRCs studied so far, this study reports a consistent and uniform decrease or absence of E-cadherin expression, associated with aberrant methylation, in the majority of carcinomas examined, suggesting an epigenetically mediated loss of E-cadherin function in these carcinomas.
|
12434413 |
2002 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In diffuse gastric carcinomas harboring CDH1 mutations, LOH was observed in a single case.
|
11313896 |
2001 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
In intestinal- and diffuse-adherent-type gastric carcinomas, we found significant associations between the presence of the CIMP and hypermethylation of several genes: hMLH1 (P = 0.006), p16(INK4a) (P = 0.018), CDH1 (P = 0.024), and RAR-beta (P = 0.044).
|
14556664 |
2003 |
|
Carcinoma
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
In this study, CDH1 promoter hypermethylation was observed in 54.8% (46/84) of the analyzed sporadic gastric carcinomas.
|
16531765 |
2006 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
In this study, methylation-specific polymerase chain reaction (PCR) was performed to study methylation of CpG islands in the promoters of the p16(INK4a), cadherin 1 (CDH1), and retinoic acid receptor-beta (RAR-beta) genes in 45 gastric carcinomas and to investigate whether CDH1 and RAR-beta promoter hypermethylation is associated with CIMP-positive gastric carcinoma.
|
12210063 |
2002 |
|
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Inactivation of the E-cadherin gene in primary gastric carcinomas and gastric carcinoma cell lines.
|
9045944 |
1996 |