|
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Promoter hypermethylation of hMLH1, p16(INK4a), and CDH1 was detected in 5/20 (25%), 8/20 (40%) and 8/20 (40%) of gastric carcinomas, respectively.
|
11496321 |
2001 |
|
Carcinoma
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
Helicobacter pylori infection in relation to E-cadherin gene promoter polymorphism and hypermethylation in sporadic gastric carcinomas.
|
16127748 |
2005 |
|
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Predictive and prognostic role of E-cadherin protein expression in patients with advanced gastric carcinomas treated with palliative chemotherapy.
|
15361706 |
2004 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Some signet ring cell carcinomas have been found to have mutations in the E-cadherin gene, which fits the above hypothesis.
|
25019985 |
2014 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our study provides strong in vivo evidence that E-cadherin gene mutations may contribute to the development of diffusely growing gastric carcinomas and support a tumor/metastasis suppressor gene hypothesis.
|
8033105 |
1994 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
CTD_human |
Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas.
|
16316942 |
2005 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In diffuse gastric carcinomas harboring CDH1 mutations, LOH was observed in a single case.
|
11313896 |
2001 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A comprehensive search using the keywords "CDH1," "E-Cadherin," "polymorphism," "SNP," and "variant" combined with "breast," "cancer," "tumor," or "carcinomas" was conducted.
|
27349965 |
2016 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Endoscopic screening in HDGC families without a pathogenic CDH1 mutation may be reasonable, as we detected signet ring cell carcinomas in 6% of persons screened.
|
28455161 |
2018 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Ongoing research focus on the search of genetic causes other than CDH1 or CTNNA1 germline defects; assessment of the pathogenicity and penetrance of CDH1 missense mutations and identification of somatic mechanisms behind the progression from early (indolent) lesions to invasive (lethal) carcinomas.
|
25439071 |
2014 |
|
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Cadherin-1 (CHD1), as an invasion suppressor gene, could suppress tumor cell invasion and metastasis in various tumors, but reduced CHD1 levels, resulting from epigenetic silencing, are common in poorly differentiated, advanced stage carcinomas.
|
24952891 |
2014 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Distinct pattern of allelic loss and inactivation of cadherin 1 and 5 genes in mammary carcinomas arising in p53(+/-) mice.
|
17327688 |
2007 |
|
Carcinoma
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
Epithelial cadherin (E-cadherin) is a classic tumor suppressor gene of the cadherin superfamily and its promoter region is usually hypermethylated in malignant carcinomas.
|
30390382 |
2019 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
As TP53 mutation and CDH1 inactivation occur in 80% of human endometrial type II carcinomas, we hypothesized that mouse uteri lacking both Trp53 and Cdh1 would exhibit a phenotype indicative of neoplastic transformation.
|
24998851 |
2015 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Mutations in the epithelial cadherin (E-cadherin) gene have been shown to be associated with the occurrence of diffuse gastric carcinomas in affected families.
|
17609302 |
2007 |
|
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Inactivation of the E-cadherin gene in primary gastric carcinomas and gastric carcinoma cell lines.
|
9045944 |
1996 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
We found high epithelial marker expressions (CK8/18, E-cadherin, membranous β-catenin) only in a distinct variety of carcinomas.
|
27729431 |
2017 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
CTD_human |
Promoter methylation as a common mechanism for inactivating E-cadherin in human salivary gland adenoid cystic carcinoma.
|
17520682 |
2007 |
|
Carcinoma
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
In this study, CDH1 promoter hypermethylation was observed in 54.8% (46/84) of the analyzed sporadic gastric carcinomas.
|
16531765 |
2006 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
This study was conducted to evaluate the promoter methylation status of p16(INK4a) and E-cadherin genes in 22 specimens of cervical carcinomas, four cervical cancer cell lines (HeLa, SiHa, Caski, C33A), and 20 human papillomavirus negative specimens, obtained from normal cervical swabs, using the methylation-specific PCR approach.
|
20112504 |
2009 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Expression of the nuclear factor ZEB1 induces an epithelial-to-mesenchymal transition and confers a metastatic phenotype on carcinomas by repressing the E-cadherin gene at the transcriptional level.
|
20418909 |
2010 |
|
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We report the absence of beta-catenin mutations in 63 sporadic colorectal carcinomas (SCRCs) with demonstrated decreased beta-catenin and E-cadherin mRNA expression and E-cadherin protein expression in a subset of carcinomas examined, suggesting that beta-catenin mutations are an extremely rare phenomenon in SCRCs and are not responsible for the transcriptional impairment of the beta-catenin/E-cadherin adhesion complex observed in these tumours.
|
12610504 |
2003 |
|
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The Cdh1 expression was investigated by immunostaining on archival formalin-fixed sections from 34 primary carcinomas and their accompanying normal epithelium and preinvasive and metastatic lesions.
|
12163387 |
2002 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The utility of this technique is demonstrated by PCR amplification and sequencing of the E-cadherin gene, which codes for a homophilic cell-to-cell adhesion molecule, in early gastric carcinomas of the diffuse type of Lauren's classification.
|
9387937 |
1998 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Alterations of the E (epithelial)-cadherin gene are often involved in undifferentiated-type carcinomas of the stomach, but not in the differentiated type.
|
10547575 |
1999 |