OPRM1, opioid receptor mu 1, 4988

N. diseases: 370; N. variants: 42
Source: ALL
Variant DSI v DPI v Chr Position Consequence Alleles Class AF EXOME AF GENOME Disease Disease Class Score vda EI vda N. PMIDs First Ref. Last Ref.
dbSNP: rs1323040
rs1323040 		0.882 0.080 6 154010889 5 prime UTR variant A/G snv 2.1E-05
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		Neoplasms; Respiratory Tract Diseases 0.010 1.000 1 2019 2019
dbSNP: rs1323040
rs1323040 		0.882 0.080 6 154010889 5 prime UTR variant A/G snv 2.1E-05
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		Neoplasms; Respiratory Tract Diseases 0.010 1.000 1 2019 2019
dbSNP: rs1323040
rs1323040 		0.882 0.080 6 154010889 5 prime UTR variant A/G snv 2.1E-05
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		Neoplasms; Respiratory Tract Diseases 0.010 1.000 1 2019 2019
dbSNP: rs9478496
rs9478496 		6 154012048 intron variant T/C;G snv
CUI: C1305855
Disease: Body mass index
Body mass index 		0.700 1.000 1 2019 2019
dbSNP: rs17174638
rs17174638 		1.000 0.080 6 154039434 stop gained C/T snv 6.3E-03 3.1E-02
CUI: C0038580
Disease: Substance Dependence
Substance Dependence 		Chemically-Induced Disorders; Mental Disorders 0.020 0.500 2 2000 2003
dbSNP: rs77114424
rs77114424 		6 154039497 missense variant G/A snv
CUI: C0030193
Disease: Pain
Pain 		Pathological Conditions, Signs and Symptoms 0.010 1.000 1 2010 2010
dbSNP: rs77114424
rs77114424 		6 154039497 missense variant G/A snv
CUI: C0150055
Disease: Chronic pain
Chronic pain 		Pathological Conditions, Signs and Symptoms 0.010 1.000 1 2010 2010
dbSNP: rs1799972
rs1799972 		0.827 0.080 6 154039561 missense variant C/A;G;T snv 4.1E-06; 1.7E-02
CUI: C0524662
Disease: Opiate Addiction
Opiate Addiction 		Chemically-Induced Disorders; Mental Disorders 0.010 < 0.001 1 2007 2007
dbSNP: rs1799972
rs1799972 		0.827 0.080 6 154039561 missense variant C/A;G;T snv 4.1E-06; 1.7E-02
CUI: C0242510
Disease: Drug usage
Drug usage 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2012 2012
dbSNP: rs1799972
rs1799972 		0.827 0.080 6 154039561 missense variant C/A;G;T snv 4.1E-06; 1.7E-02
CUI: C0038580
Disease: Substance Dependence
Substance Dependence 		Chemically-Induced Disorders; Mental Disorders 0.010 < 0.001 1 2012 2012
dbSNP: rs1799972
rs1799972 		0.827 0.080 6 154039561 missense variant C/A;G;T snv 4.1E-06; 1.7E-02
CUI: C0028768
Disease: Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder 		Mental Disorders 0.010 1.000 1 2004 2004
dbSNP: rs1799972
rs1799972 		0.827 0.080 6 154039561 missense variant C/A;G;T snv 4.1E-06; 1.7E-02
CUI: C0740858
Disease: Substance abuse problem
Substance abuse problem 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2007 2007
dbSNP: rs1799972
rs1799972 		0.827 0.080 6 154039561 missense variant C/A;G;T snv 4.1E-06; 1.7E-02
CUI: C3854222
Disease: Human immunodeficiency virus (HIV) II infection category B1
Human immunodeficiency virus (HIV) II infection category B1 		0.010 1.000 1 2012 2012
dbSNP: rs1187761291
rs1187761291 		1.000 0.120 6 154039569 missense variant A/G snv 4.1E-06
CUI: C0563625
Disease: Agnosia for Pain
Agnosia for Pain 		Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms 0.010 < 0.001 1 2010 2010
dbSNP: rs111339162
rs111339162 		1.000 0.040 6 154039596 missense variant G/A snv 2.0E-05 1.4E-04
CUI: C1842981
Disease: NEUROTICISM
NEUROTICISM 		Behavior and Behavior Mechanisms 0.010 1.000 1 2018 2018
dbSNP: rs780726314
rs780726314 		1.000 0.080 6 154039624 missense variant G/T snv 1.2E-05 7.0E-06
CUI: C0019337
Disease: Heroin Dependence
Heroin Dependence 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2002 2002
dbSNP: rs199953844
rs199953844 		6 154039650 missense variant C/A;T snv 4.0E-06; 1.2E-04
CUI: C0549393
Disease: Alcohol problem
Alcohol problem 		0.010 1.000 1 2014 2014
dbSNP: rs199953844
rs199953844 		6 154039650 missense variant C/A;T snv 4.0E-06; 1.2E-04
CUI: C1510472
Disease: Drug Dependence
Drug Dependence 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2014 2014
dbSNP: rs1799971
rs1799971 		0.559 0.600 6 154039662 missense variant A/G snv 0.19 0.12
CUI: C0030193
Disease: Pain
Pain 		Pathological Conditions, Signs and Symptoms 0.100 0.979 47 2004 2019
dbSNP: rs1799971
rs1799971 		0.559 0.600 6 154039662 missense variant A/G snv 0.19 0.12
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		Chemically-Induced Disorders; Mental Disorders 0.100 0.893 28 1998 2019
dbSNP: rs1799971
rs1799971 		0.559 0.600 6 154039662 missense variant A/G snv 0.19 0.12
CUI: C0563625
Disease: Agnosia for Pain
Agnosia for Pain 		Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms 0.100 0.944 18 2006 2019
dbSNP: rs1799971
rs1799971 		0.559 0.600 6 154039662 missense variant A/G snv 0.19 0.12
CUI: C0524662
Disease: Opiate Addiction
Opiate Addiction 		Chemically-Induced Disorders; Mental Disorders 0.100 0.900 10 2001 2020
dbSNP: rs1799971
rs1799971 		0.559 0.600 6 154039662 missense variant A/G snv 0.19 0.12
CUI: C0085281
Disease: Addictive Behavior
Addictive Behavior 		Behavior and Behavior Mechanisms 0.090 1.000 9 2004 2019
dbSNP: rs1799971
rs1799971 		0.559 0.600 6 154039662 missense variant A/G snv 0.19 0.12
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		Chemically-Induced Disorders; Mental Disorders 0.070 0.857 7 2010 2018
dbSNP: rs1799971
rs1799971 		0.559 0.600 6 154039662 missense variant A/G snv 0.19 0.12
CUI: C0019337
Disease: Heroin Dependence
Heroin Dependence 		Chemically-Induced Disorders; Mental Disorders 0.070 0.857 7 2001 2017