OPRM1, opioid receptor mu 1, 4988

N. diseases: 370; N. variants: 42
Source: ALL
Variant DSI v DPI v Chr Position Consequence Alleles Class AF EXOME AF GENOME Disease Disease Class Score vda EI vda N. PMIDs First Ref. Last Ref.
dbSNP: rs780726314
rs780726314 		1.000 0.080 6 154039624 missense variant G/T snv 1.2E-05 7.0E-06
CUI: C0019337
Disease: Heroin Dependence
Heroin Dependence 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2002 2002
dbSNP: rs17174638
rs17174638 		1.000 0.080 6 154039434 stop gained C/T snv 6.3E-03 3.1E-02
CUI: C0038580
Disease: Substance Dependence
Substance Dependence 		Chemically-Induced Disorders; Mental Disorders 0.020 0.500 2 2000 2003
dbSNP: rs1799971
rs1799971 		0.559 0.600 6 154039662 missense variant A/G snv 0.19 0.12
CUI: C0028768
Disease: Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder 		Mental Disorders 0.010 1.000 1 2004 2004
dbSNP: rs1799971
rs1799971 		0.559 0.600 6 154039662 missense variant A/G snv 0.19 0.12
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders 		Mental Disorders 0.010 1.000 1 2004 2004
dbSNP: rs1799971
rs1799971 		0.559 0.600 6 154039662 missense variant A/G snv 0.19 0.12
CUI: C0233477
Disease: Dysphoric mood
Dysphoric mood 		Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms 0.010 1.000 1 2004 2004
dbSNP: rs1799971
rs1799971 		0.559 0.600 6 154039662 missense variant A/G snv 0.19 0.12
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis 		Mental Disorders 0.010 1.000 1 2004 2004
dbSNP: rs1799972
rs1799972 		0.827 0.080 6 154039561 missense variant C/A;G;T snv 4.1E-06; 1.7E-02
CUI: C0028768
Disease: Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder 		Mental Disorders 0.010 1.000 1 2004 2004
dbSNP: rs769540300
rs769540300 		0.851 0.200 6 154091047 missense variant G/A snv 1.2E-05
CUI: C0003467
Disease: Anxiety
Anxiety 		Behavior and Behavior Mechanisms 0.010 1.000 1 2004 2004
dbSNP: rs769540300
rs769540300 		0.851 0.200 6 154091047 missense variant G/A snv 1.2E-05
CUI: C0233477
Disease: Dysphoric mood
Dysphoric mood 		Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms 0.010 1.000 1 2004 2004
dbSNP: rs769540300
rs769540300 		0.851 0.200 6 154091047 missense variant G/A snv 1.2E-05
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		Mental Disorders 0.010 1.000 1 2004 2004
dbSNP: rs769540300
rs769540300 		0.851 0.200 6 154091047 missense variant G/A snv 1.2E-05
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2004 2004
dbSNP: rs769540300
rs769540300 		0.851 0.200 6 154091047 missense variant G/A snv 1.2E-05
CUI: C0085281
Disease: Addictive Behavior
Addictive Behavior 		Behavior and Behavior Mechanisms 0.010 1.000 1 2004 2004
dbSNP: rs1799971
rs1799971 		0.559 0.600 6 154039662 missense variant A/G snv 0.19 0.12
CUI: C0013384
Disease: Dyskinetic syndrome
Dyskinetic syndrome 		Pathological Conditions, Signs and Symptoms; Nervous System Diseases 0.010 1.000 1 2006 2006
dbSNP: rs1799971
rs1799971 		0.559 0.600 6 154039662 missense variant A/G snv 0.19 0.12
CUI: C0270850
Disease: Idiopathic generalized epilepsy
Idiopathic generalized epilepsy 		Nervous System Diseases 0.010 < 0.001 1 2006 2006
dbSNP: rs1799971
rs1799971 		0.559 0.600 6 154039662 missense variant A/G snv 0.19 0.12
CUI: C0600241
Disease: heroin abuse
heroin abuse 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2006 2006
dbSNP: rs648007
rs648007 		1.000 0.080 6 154101476 intron variant A/G snv 0.64
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		Nutritional and Metabolic Diseases; Endocrine System Diseases 0.010 1.000 1 2006 2006
dbSNP: rs1799971
rs1799971 		0.559 0.600 6 154039662 missense variant A/G snv 0.19 0.12
CUI: C0740858
Disease: Substance abuse problem
Substance abuse problem 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2007 2007
dbSNP: rs1799972
rs1799972 		0.827 0.080 6 154039561 missense variant C/A;G;T snv 4.1E-06; 1.7E-02
CUI: C0524662
Disease: Opiate Addiction
Opiate Addiction 		Chemically-Induced Disorders; Mental Disorders 0.010 < 0.001 1 2007 2007
dbSNP: rs1799972
rs1799972 		0.827 0.080 6 154039561 missense variant C/A;G;T snv 4.1E-06; 1.7E-02
CUI: C0740858
Disease: Substance abuse problem
Substance abuse problem 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2007 2007
dbSNP: rs1799971
rs1799971 		0.559 0.600 6 154039662 missense variant A/G snv 0.19 0.12
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		Pathological Conditions, Signs and Symptoms; Digestive System Diseases 0.010 1.000 1 2008 2008
dbSNP: rs1799971
rs1799971 		0.559 0.600 6 154039662 missense variant A/G snv 0.19 0.12
CUI: C0008370
Disease: Cholestasis
Cholestasis 		Digestive System Diseases 0.010 1.000 1 2008 2008
dbSNP: rs1799971
rs1799971 		0.559 0.600 6 154039662 missense variant A/G snv 0.19 0.12
CUI: C0184567
Disease: Acute onset pain
Acute onset pain 		Pathological Conditions, Signs and Symptoms 0.010 1.000 1 2008 2008
dbSNP: rs199682734
rs199682734 		6 154118718 synonymous variant C/T snv 8.1E-06 7.0E-06
CUI: C0015672
Disease: Fatigue
Fatigue 		Pathological Conditions, Signs and Symptoms 0.010 1.000 1 2008 2008
dbSNP: rs510769
rs510769 		1.000 0.080 6 154040884 intron variant C/T snv 0.25
CUI: C0019337
Disease: Heroin Dependence
Heroin Dependence 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2008 2008
dbSNP: rs1799971
rs1799971 		0.559 0.600 6 154039662 missense variant A/G snv 0.19 0.12
CUI: C0028754
Disease: Obesity
Obesity 		Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases 0.010 1.000 1 2009 2009