|
rs10798269
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
|
0.810 |
GeneticVariation |
GWASDB |
Aside from the expected strong association between SLE and the HLA region on chromosome 6p21 and the previously confirmed non-HLA locus IRF5 on chromosome 7q32, we found evidence of association with replication (1.1 x 10(-7) < P(overall) < 1.6 x 10(-23); odds ratio = 0.82-1.62) in four regions: 16p11.2 (ITGAM), 11p15.5 (KIAA1542), 3p14.3 (PXK) and 1q25.1 (rs10798269).
|
18204446 |
2008 |
|
rs10798269
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
|
0.810 |
GeneticVariation |
BEFREE |
Aside from the expected strong association between SLE and the HLA region on chromosome 6p21 and the previously confirmed non-HLA locus IRF5 on chromosome 7q32, we found evidence of association with replication (1.1 x 10(-7) < P(overall) < 1.6 x 10(-23); odds ratio = 0.82-1.62) in four regions: 16p11.2 (ITGAM), 11p15.5 (KIAA1542), 3p14.3 (PXK) and 1q25.1 (rs10798269).
|
18204446 |
2008 |
|
rs10798269
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
|
0.810 |
GeneticVariation |
GWASCAT |
Aside from the expected strong association between SLE and the HLA region on chromosome 6p21 and the previously confirmed non-HLA locus IRF5 on chromosome 7q32, we found evidence of association with replication (1.1 x 10(-7) < P(overall) < 1.6 x 10(-23); odds ratio = 0.82-1.62) in four regions: 16p11.2 (ITGAM), 11p15.5 (KIAA1542), 3p14.3 (PXK) and 1q25.1 (rs10798269).
|
18204446 |
2008 |
|
rs844648
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
|
0.720 |
GeneticVariation |
BEFREE |
In TNFSF4, rs2205960 was associated with SLE independently from the effect of rs844648 (P=6.26 x 10(-3)), but not vice versa (P=0.55).
|
19357697 |
2009 |
|
rs844648
|
TNFSF4;LOC100506023
|
Systemic Scleroderma
|
|
0.020 |
GeneticVariation |
BEFREE |
Case-control comparisons revealed a significant association between susceptibility to SSc and the minor alleles at SNPs rs1234314 (OR 1.20, 95% CI 1.04 to 1.4, p(FDR)=0.019), rs2205960 (OR 1.24, 95% CI 1.10 to 1.50, p(FDR)=0.019) and rs844648 (OR 1.16, 95% CI 1.01 to 1.30, p(FDR)=0.032).
|
19778912 |
2010 |
|
rs12039904
|
TNFSF4;LOC100506023
|
Systemic Scleroderma
|
|
0.020 |
GeneticVariation |
BEFREE |
A pooled analysis revealed the association of rs1234314 and rs12039904 polymorphisms with SSc (OR 1.15, 95% CI 1.02 to 1.31; OR 1.18, 95% CI 1.08 to 1.29, respectively).
|
21187296 |
2011 |
|
rs12039904
|
TNFSF4;LOC100506023
|
Systemic Scleroderma
|
|
0.020 |
GeneticVariation |
BEFREE |
Known SLE and SSc TNFSF4 susceptibility variants (rs2205960, rs1234317, rs12039904, rs10912580, and rs844648) were genotyped in 1031 patients with SSc and 1014 controls of French white ancestry.
|
22422496 |
2012 |
|
rs844648
|
TNFSF4;LOC100506023
|
Systemic Scleroderma
|
|
0.020 |
GeneticVariation |
BEFREE |
Known SLE and SSc TNFSF4 susceptibility variants (rs2205960, rs1234317, rs12039904, rs10912580, and rs844648) were genotyped in 1031 patients with SSc and 1014 controls of French white ancestry.
|
22422496 |
2012 |
|
rs10912580
|
TNFSF4;LOC100506023
|
Systemic Scleroderma
|
|
0.010 |
GeneticVariation |
BEFREE |
Known SLE and SSc TNFSF4 susceptibility variants (rs2205960, rs1234317, rs12039904, rs10912580, and rs844648) were genotyped in 1031 patients with SSc and 1014 controls of French white ancestry.
|
22422496 |
2012 |
|
rs10489265
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
|
0.720 |
GeneticVariation |
BEFREE |
Meta-analysis revealed an association between the minor alleles of rs1234315 and rs10489265 of TNFSF4 and SLE in Asians (OR=1.366, 95% CI=1.295-1.440, p<1.0×10(-9); OR=1.463, 95% CI=1.208-1.771, p=9.7×10(-5)).
|
22820624 |
2012 |
|
rs844648
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
|
0.720 |
GeneticVariation |
BEFREE |
No association was found between the rs844644 and rs844648 polymorphisms and SLE.
|
22850862 |
2013 |
|
rs844644
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation |
BEFREE |
No association was found between the rs844644 and rs844648 polymorphisms and SLE.
|
22850862 |
2013 |
|
rs10912580
|
TNFSF4;LOC100506023
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype analysis showed that haplotype A(rs844648)A(rs10912580) was significantly associated with breast cancer, even after 10,000 permutations for haplotypes in block only (P = 0.0003).
|
22870213 |
2012 |
|
rs10912580
|
TNFSF4;LOC100506023
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype analysis showed that haplotype A(rs844648)A(rs10912580) was significantly associated with breast cancer, even after 10,000 permutations for haplotypes in block only (P = 0.0003).
|
22870213 |
2012 |
|
rs844648
|
TNFSF4;LOC100506023
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype analysis showed that haplotype A(rs844648)A(rs10912580) was significantly associated with breast cancer, even after 10,000 permutations for haplotypes in block only (P = 0.0003).
|
22870213 |
2012 |
|
rs844648
|
TNFSF4;LOC100506023
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype analysis showed that haplotype A(rs844648)A(rs10912580) was significantly associated with breast cancer, even after 10,000 permutations for haplotypes in block only (P = 0.0003).
|
22870213 |
2012 |
|
rs704840
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
|
0.810 |
GeneticVariation |
GWASDB |
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
|
23273568 |
2013 |
|
rs10489265
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
|
0.720 |
GeneticVariation |
GWASDB |
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
|
23273568 |
2013 |
|
rs844648
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
|
0.720 |
GeneticVariation |
GWASDB |
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
|
23273568 |
2013 |
|
rs1012507
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
|
0.700 |
GeneticVariation |
GWASDB |
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
|
23273568 |
2013 |
|
rs704840
|
TNFSF4;LOC100506023
|
Primary Sjögren's syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
Weak associations were observed when the SNPs in TNFSF4 (rs2205960, rs844648 and rs704840) and FAM167A-BLK (rs7812879, rs2254546 and rs2618479) were directly analyzed or analyzed under dominant model between pSS and controls (all P<0.05).
|
23635951 |
2013 |
|
rs844648
|
TNFSF4;LOC100506023
|
Primary Sjögren's syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
Weak associations were observed when the SNPs in TNFSF4 (rs2205960, rs844648 and rs704840) and FAM167A-BLK (rs7812879, rs2254546 and rs2618479) were directly analyzed or analyzed under dominant model between pSS and controls (all P<0.05).
|
23635951 |
2013 |
|
rs704840
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
|
0.810 |
GeneticVariation |
GWASCAT |
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
|
23740937 |
2013 |
|
rs1857066
|
TNFSF4;LOC100506023
|
Systemic Scleroderma
|
|
0.800 |
GeneticVariation |
GWASDB |
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
|
23740937 |
2013 |
|
rs704840
|
TNFSF4;LOC100506023
|
Systemic Scleroderma
|
|
0.800 |
GeneticVariation |
GWASCAT |
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
|
23740937 |
2013 |