Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1012507
rs1012507
Entrez Id: 7292;100506023
Gene Symbol: TNFSF4;LOC100506023
TNFSF4;LOC100506023
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.700 GeneticVariation GWASDB Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. 23273568 2013
dbSNP: rs10489265
rs10489265
Entrez Id: 7292;100506023
Gene Symbol: TNFSF4;LOC100506023
TNFSF4;LOC100506023
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.720 GeneticVariation BEFREE The SNPs of TNFSF4 were associated with renal involvement in lupus patients from the Chinese population (P values for rs2205960 and rs10489265 were 0.014 and 0.005 in additive model, resp.). 23936824 2013
dbSNP: rs10489265
rs10489265
Entrez Id: 7292;100506023
Gene Symbol: TNFSF4;LOC100506023
TNFSF4;LOC100506023
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.720 GeneticVariation GWASDB Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. 23273568 2013
dbSNP: rs10489265
rs10489265
Entrez Id: 7292;100506023
Gene Symbol: TNFSF4;LOC100506023
TNFSF4;LOC100506023
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.720 GeneticVariation BEFREE Meta-analysis revealed an association between the minor alleles of rs1234315 and rs10489265 of TNFSF4 and SLE in Asians (OR=1.366, 95% CI=1.295-1.440, p<1.0×10(-9); OR=1.463, 95% CI=1.208-1.771, p=9.7×10(-5)). 22820624 2012
dbSNP: rs10489265
rs10489265
Entrez Id: 7292;100506023
Gene Symbol: TNFSF4;LOC100506023
TNFSF4;LOC100506023
CUI: C0409974
Disease:
Lupus Erythematosus
0.010 GeneticVariation BEFREE The SNPs of TNFSF4 were associated with renal involvement in lupus patients from the Chinese population (P values for rs2205960 and rs10489265 were 0.014 and 0.005 in additive model, resp.). 23936824 2013
dbSNP: rs10489265
rs10489265
Entrez Id: 7292;100506023
Gene Symbol: TNFSF4;LOC100506023
TNFSF4;LOC100506023
CUI: C0024131
Disease:
Lupus Vulgaris
0.010 GeneticVariation BEFREE The SNPs of TNFSF4 were associated with renal involvement in lupus patients from the Chinese population (P values for rs2205960 and rs10489265 were 0.014 and 0.005 in additive model, resp.). 23936824 2013
dbSNP: rs10489265
rs10489265
Entrez Id: 7292;100506023
Gene Symbol: TNFSF4;LOC100506023
TNFSF4;LOC100506023
CUI: C0024138
Disease:
Lupus Erythematosus, Discoid
0.010 GeneticVariation BEFREE The SNPs of TNFSF4 were associated with renal involvement in lupus patients from the Chinese population (P values for rs2205960 and rs10489265 were 0.014 and 0.005 in additive model, resp.). 23936824 2013
dbSNP: rs10489265
rs10489265
Entrez Id: 7292;100506023
Gene Symbol: TNFSF4;LOC100506023
TNFSF4;LOC100506023
CUI: C0014060
Disease:
Encephalitis, St. Louis
0.010 GeneticVariation BEFREE To replicate the association, two single-nucleotide polymorphisms (SNPs: rs2205960 and rs10489265) were genotyped in 814 SLE patients. 23936824 2013
dbSNP: rs10753074
rs10753074
Entrez Id: 7292;100506023
Gene Symbol: TNFSF4;LOC100506023
TNFSF4;LOC100506023
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
T 0.700 GeneticVariation GWASCAT Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus. 26502338 2015
dbSNP: rs10798269
rs10798269
Entrez Id: 7292;100506023
Gene Symbol: TNFSF4;LOC100506023
TNFSF4;LOC100506023
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.810 GeneticVariation GWASDB Aside from the expected strong association between SLE and the HLA region on chromosome 6p21 and the previously confirmed non-HLA locus IRF5 on chromosome 7q32, we found evidence of association with replication (1.1 x 10(-7) < P(overall) < 1.6 x 10(-23); odds ratio = 0.82-1.62) in four regions: 16p11.2 (ITGAM), 11p15.5 (KIAA1542), 3p14.3 (PXK) and 1q25.1 (rs10798269). 18204446 2008
dbSNP: rs10798269
rs10798269
Entrez Id: 7292;100506023
Gene Symbol: TNFSF4;LOC100506023
TNFSF4;LOC100506023
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.810 GeneticVariation BEFREE Aside from the expected strong association between SLE and the HLA region on chromosome 6p21 and the previously confirmed non-HLA locus IRF5 on chromosome 7q32, we found evidence of association with replication (1.1 x 10(-7) < P(overall) < 1.6 x 10(-23); odds ratio = 0.82-1.62) in four regions: 16p11.2 (ITGAM), 11p15.5 (KIAA1542), 3p14.3 (PXK) and 1q25.1 (rs10798269). 18204446 2008
dbSNP: rs10798269
rs10798269
Entrez Id: 7292;100506023
Gene Symbol: TNFSF4;LOC100506023
TNFSF4;LOC100506023
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.810 GeneticVariation GWASCAT Aside from the expected strong association between SLE and the HLA region on chromosome 6p21 and the previously confirmed non-HLA locus IRF5 on chromosome 7q32, we found evidence of association with replication (1.1 x 10(-7) < P(overall) < 1.6 x 10(-23); odds ratio = 0.82-1.62) in four regions: 16p11.2 (ITGAM), 11p15.5 (KIAA1542), 3p14.3 (PXK) and 1q25.1 (rs10798269). 18204446 2008
dbSNP: rs10912578
rs10912578
Entrez Id: 7292;100506023
Gene Symbol: TNFSF4;LOC100506023
TNFSF4;LOC100506023
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.700 GeneticVariation GWASCAT Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus. 27399966 2016
dbSNP: rs10912578
rs10912578
Entrez Id: 7292;100506023
Gene Symbol: TNFSF4;LOC100506023
TNFSF4;LOC100506023
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
A 0.700 GeneticVariation GWASCAT Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus. 26502338 2015
dbSNP: rs10912580
rs10912580
Entrez Id: 7292;100506023
Gene Symbol: TNFSF4;LOC100506023
TNFSF4;LOC100506023
CUI: C0678222
Disease:
Breast Carcinoma
0.010 GeneticVariation BEFREE The haplotype analysis showed that haplotype A(rs844648)A(rs10912580) was significantly associated with breast cancer, even after 10,000 permutations for haplotypes in block only (P = 0.0003). 22870213 2012
dbSNP: rs10912580
rs10912580
Entrez Id: 7292;100506023
Gene Symbol: TNFSF4;LOC100506023
TNFSF4;LOC100506023
CUI: C0036421
Disease:
Systemic Scleroderma
0.010 GeneticVariation BEFREE Known SLE and SSc TNFSF4 susceptibility variants (rs2205960, rs1234317, rs12039904, rs10912580, and rs844648) were genotyped in 1031 patients with SSc and 1014 controls of French white ancestry. 22422496 2012
dbSNP: rs10912580
rs10912580
Entrez Id: 7292;100506023
Gene Symbol: TNFSF4;LOC100506023
TNFSF4;LOC100506023
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.010 GeneticVariation BEFREE The haplotype analysis showed that haplotype A(rs844648)A(rs10912580) was significantly associated with breast cancer, even after 10,000 permutations for haplotypes in block only (P = 0.0003). 22870213 2012
dbSNP: rs1099448
rs1099448
Entrez Id: 7292;100506023
Gene Symbol: TNFSF4;LOC100506023
TNFSF4;LOC100506023
CUI: C0200638
Disease:
Eosinophil count procedure
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs12039904
rs12039904
Entrez Id: 7292;100506023
Gene Symbol: TNFSF4;LOC100506023
TNFSF4;LOC100506023
CUI: C0036421
Disease:
Systemic Scleroderma
0.020 GeneticVariation BEFREE Known SLE and SSc TNFSF4 susceptibility variants (rs2205960, rs1234317, rs12039904, rs10912580, and rs844648) were genotyped in 1031 patients with SSc and 1014 controls of French white ancestry. 22422496 2012
dbSNP: rs12039904
rs12039904
Entrez Id: 7292;100506023
Gene Symbol: TNFSF4;LOC100506023
TNFSF4;LOC100506023
CUI: C0036421
Disease:
Systemic Scleroderma
0.020 GeneticVariation BEFREE A pooled analysis revealed the association of rs1234314 and rs12039904 polymorphisms with SSc (OR 1.15, 95% CI 1.02 to 1.31; OR 1.18, 95% CI 1.08 to 1.29, respectively). 21187296 2011
dbSNP: rs12736195
rs12736195
Entrez Id: 7292;100506023
Gene Symbol: TNFSF4;LOC100506023
TNFSF4;LOC100506023
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.700 GeneticVariation GWASCAT Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture. 26606652 2016
dbSNP: rs1418190
rs1418190
Entrez Id: 7292;100506023
Gene Symbol: TNFSF4;LOC100506023
TNFSF4;LOC100506023
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.010 GeneticVariation BEFREE This replication effort confirmed five reported SLE susceptibility loci reaching genome-wide levels of significance (P(meta) <5.00 × 10(-08)): TNFSF4 (rs1418190, odds ratio (OR) = 0.81, P(meta) = 1.08 × 10(-08); rs4916219, OR = 0.80, P(meta )= 7.77 × 10(-09)), IRF8 (rs2934498, OR = 1.25, P(meta) = 4.97 × 10(-09)), miR-146a (rs2431697, OR = 0.69, P(meta) = 1.15 × 10(-22)), CD44 (rs2732547, OR = 0.82, P(meta) = 1.55 × 10(-11)), and TMEM39A (rs12494314, OR = 0.84, P(meta) = 1.01 × 10(-09)). 25890262 2015
dbSNP: rs1857066
rs1857066
Entrez Id: 7292;100506023
Gene Symbol: TNFSF4;LOC100506023
TNFSF4;LOC100506023
CUI: C0036421
Disease:
Systemic Scleroderma
0.800 GeneticVariation GWASDB A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. 23740937 2013
dbSNP: rs1857066
rs1857066
Entrez Id: 7292;100506023
Gene Symbol: TNFSF4;LOC100506023
TNFSF4;LOC100506023
CUI: C0036421
Disease:
Systemic Scleroderma
0.800 GeneticVariation GWASCAT GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. 31672989 2019
dbSNP: rs2105325
rs2105325
Entrez Id: 7292;100506023
Gene Symbol: TNFSF4;LOC100506023
TNFSF4;LOC100506023
CUI: C0003873
Disease:
Rheumatoid Arthritis
C 0.800 GeneticVariation GWASDB Genetics of rheumatoid arthritis contributes to biology and drug discovery. 24390342 2014