rs1012507
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
|
0.700 |
GeneticVariation |
GWASDB |
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
|
23273568 |
2013 |
rs10489265
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
|
0.720 |
GeneticVariation |
BEFREE |
The SNPs of TNFSF4 were associated with renal involvement in lupus patients from the Chinese population (P values for rs2205960 and rs10489265 were 0.014 and 0.005 in additive model, resp.).
|
23936824 |
2013 |
rs10489265
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
|
0.720 |
GeneticVariation |
GWASDB |
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
|
23273568 |
2013 |
rs10489265
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
|
0.720 |
GeneticVariation |
BEFREE |
Meta-analysis revealed an association between the minor alleles of rs1234315 and rs10489265 of TNFSF4 and SLE in Asians (OR=1.366, 95% CI=1.295-1.440, p<1.0×10(-9); OR=1.463, 95% CI=1.208-1.771, p=9.7×10(-5)).
|
22820624 |
2012 |
rs10489265
|
TNFSF4;LOC100506023
|
Lupus Erythematosus
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNPs of TNFSF4 were associated with renal involvement in lupus patients from the Chinese population (P values for rs2205960 and rs10489265 were 0.014 and 0.005 in additive model, resp.).
|
23936824 |
2013 |
rs10489265
|
TNFSF4;LOC100506023
|
Lupus Vulgaris
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNPs of TNFSF4 were associated with renal involvement in lupus patients from the Chinese population (P values for rs2205960 and rs10489265 were 0.014 and 0.005 in additive model, resp.).
|
23936824 |
2013 |
rs10489265
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Discoid
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNPs of TNFSF4 were associated with renal involvement in lupus patients from the Chinese population (P values for rs2205960 and rs10489265 were 0.014 and 0.005 in additive model, resp.).
|
23936824 |
2013 |
rs10489265
|
TNFSF4;LOC100506023
|
Encephalitis, St. Louis
|
|
0.010 |
GeneticVariation |
BEFREE |
To replicate the association, two single-nucleotide polymorphisms (SNPs: rs2205960 and rs10489265) were genotyped in 814 SLE patients.
|
23936824 |
2013 |
rs10753074
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.
|
26502338 |
2015 |
rs10798269
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
|
0.810 |
GeneticVariation |
GWASDB |
Aside from the expected strong association between SLE and the HLA region on chromosome 6p21 and the previously confirmed non-HLA locus IRF5 on chromosome 7q32, we found evidence of association with replication (1.1 x 10(-7) < P(overall) < 1.6 x 10(-23); odds ratio = 0.82-1.62) in four regions: 16p11.2 (ITGAM), 11p15.5 (KIAA1542), 3p14.3 (PXK) and 1q25.1 (rs10798269).
|
18204446 |
2008 |
rs10798269
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
|
0.810 |
GeneticVariation |
BEFREE |
Aside from the expected strong association between SLE and the HLA region on chromosome 6p21 and the previously confirmed non-HLA locus IRF5 on chromosome 7q32, we found evidence of association with replication (1.1 x 10(-7) < P(overall) < 1.6 x 10(-23); odds ratio = 0.82-1.62) in four regions: 16p11.2 (ITGAM), 11p15.5 (KIAA1542), 3p14.3 (PXK) and 1q25.1 (rs10798269).
|
18204446 |
2008 |
rs10798269
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
|
0.810 |
GeneticVariation |
GWASCAT |
Aside from the expected strong association between SLE and the HLA region on chromosome 6p21 and the previously confirmed non-HLA locus IRF5 on chromosome 7q32, we found evidence of association with replication (1.1 x 10(-7) < P(overall) < 1.6 x 10(-23); odds ratio = 0.82-1.62) in four regions: 16p11.2 (ITGAM), 11p15.5 (KIAA1542), 3p14.3 (PXK) and 1q25.1 (rs10798269).
|
18204446 |
2008 |
rs10912578
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus.
|
27399966 |
2016 |
rs10912578
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.
|
26502338 |
2015 |
rs10912580
|
TNFSF4;LOC100506023
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype analysis showed that haplotype A(rs844648)A(rs10912580) was significantly associated with breast cancer, even after 10,000 permutations for haplotypes in block only (P = 0.0003).
|
22870213 |
2012 |
rs10912580
|
TNFSF4;LOC100506023
|
Systemic Scleroderma
|
|
0.010 |
GeneticVariation |
BEFREE |
Known SLE and SSc TNFSF4 susceptibility variants (rs2205960, rs1234317, rs12039904, rs10912580, and rs844648) were genotyped in 1031 patients with SSc and 1014 controls of French white ancestry.
|
22422496 |
2012 |
rs10912580
|
TNFSF4;LOC100506023
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype analysis showed that haplotype A(rs844648)A(rs10912580) was significantly associated with breast cancer, even after 10,000 permutations for haplotypes in block only (P = 0.0003).
|
22870213 |
2012 |
rs1099448
|
TNFSF4;LOC100506023
|
Eosinophil count procedure
|
|
0.700 |
GeneticVariation |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
rs12039904
|
TNFSF4;LOC100506023
|
Systemic Scleroderma
|
|
0.020 |
GeneticVariation |
BEFREE |
Known SLE and SSc TNFSF4 susceptibility variants (rs2205960, rs1234317, rs12039904, rs10912580, and rs844648) were genotyped in 1031 patients with SSc and 1014 controls of French white ancestry.
|
22422496 |
2012 |
rs12039904
|
TNFSF4;LOC100506023
|
Systemic Scleroderma
|
|
0.020 |
GeneticVariation |
BEFREE |
A pooled analysis revealed the association of rs1234314 and rs12039904 polymorphisms with SSc (OR 1.15, 95% CI 1.02 to 1.31; OR 1.18, 95% CI 1.08 to 1.29, respectively).
|
21187296 |
2011 |
rs12736195
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture.
|
26606652 |
2016 |
rs1418190
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation |
BEFREE |
This replication effort confirmed five reported SLE susceptibility loci reaching genome-wide levels of significance (P(meta) <5.00 × 10(-08)): TNFSF4 (rs1418190, odds ratio (OR) = 0.81, P(meta) = 1.08 × 10(-08); rs4916219, OR = 0.80, P(meta )= 7.77 × 10(-09)), IRF8 (rs2934498, OR = 1.25, P(meta) = 4.97 × 10(-09)), miR-146a (rs2431697, OR = 0.69, P(meta) = 1.15 × 10(-22)), CD44 (rs2732547, OR = 0.82, P(meta) = 1.55 × 10(-11)), and TMEM39A (rs12494314, OR = 0.84, P(meta) = 1.01 × 10(-09)).
|
25890262 |
2015 |
rs1857066
|
TNFSF4;LOC100506023
|
Systemic Scleroderma
|
|
0.800 |
GeneticVariation |
GWASDB |
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
|
23740937 |
2013 |
rs1857066
|
TNFSF4;LOC100506023
|
Systemic Scleroderma
|
|
0.800 |
GeneticVariation |
GWASCAT |
GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways.
|
31672989 |
2019 |
rs2105325
|
TNFSF4;LOC100506023
|
Rheumatoid Arthritis
|
C |
0.800 |
GeneticVariation |
GWASDB |
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
|
24390342 |
2014 |