|
rs704840
|
TNFSF4;LOC100506023
|
Neuromyelitis Optica
|
|
0.010 |
GeneticVariation |
BEFREE |
Significant associations of rs844648 (OR = 1.67, 95% CI 1.17-2.38, P = 0.005, Pcorr = 0.02) and rs704840 (OR = 1.75, 95% CI 1.17-2.63, P = 0.007, Pcorr = 0.027) with NMOSD occurrence were also observed under the recessive model.
|
29032462 |
2017 |
|
rs844648
|
TNFSF4;LOC100506023
|
Neuromyelitis Optica
|
|
0.010 |
GeneticVariation |
BEFREE |
Significant associations of rs844648 (OR = 1.67, 95% CI 1.17-2.38, P = 0.005, Pcorr = 0.02) and rs704840 (OR = 1.75, 95% CI 1.17-2.63, P = 0.007, Pcorr = 0.027) with NMOSD occurrence were also observed under the recessive model.
|
29032462 |
2017 |
|
rs1418190
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation |
BEFREE |
This replication effort confirmed five reported SLE susceptibility loci reaching genome-wide levels of significance (P(meta) <5.00 × 10(-08)): TNFSF4 (rs1418190, odds ratio (OR) = 0.81, P(meta) = 1.08 × 10(-08); rs4916219, OR = 0.80, P(meta )= 7.77 × 10(-09)), IRF8 (rs2934498, OR = 1.25, P(meta) = 4.97 × 10(-09)), miR-146a (rs2431697, OR = 0.69, P(meta) = 1.15 × 10(-22)), CD44 (rs2732547, OR = 0.82, P(meta) = 1.55 × 10(-11)), and TMEM39A (rs12494314, OR = 0.84, P(meta) = 1.01 × 10(-09)).
|
25890262 |
2015 |
|
rs4916219
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation |
BEFREE |
This replication effort confirmed five reported SLE susceptibility loci reaching genome-wide levels of significance (P(meta) <5.00 × 10(-08)): TNFSF4 (rs1418190, odds ratio (OR) = 0.81, P(meta) = 1.08 × 10(-08); rs4916219, OR = 0.80, P(meta )= 7.77 × 10(-09)), IRF8 (rs2934498, OR = 1.25, P(meta) = 4.97 × 10(-09)), miR-146a (rs2431697, OR = 0.69, P(meta) = 1.15 × 10(-22)), CD44 (rs2732547, OR = 0.82, P(meta) = 1.55 × 10(-11)), and TMEM39A (rs12494314, OR = 0.84, P(meta) = 1.01 × 10(-09)).
|
25890262 |
2015 |
|
rs10489265
|
TNFSF4;LOC100506023
|
Lupus Erythematosus
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNPs of TNFSF4 were associated with renal involvement in lupus patients from the Chinese population (P values for rs2205960 and rs10489265 were 0.014 and 0.005 in additive model, resp.).
|
23936824 |
2013 |
|
rs10489265
|
TNFSF4;LOC100506023
|
Lupus Vulgaris
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNPs of TNFSF4 were associated with renal involvement in lupus patients from the Chinese population (P values for rs2205960 and rs10489265 were 0.014 and 0.005 in additive model, resp.).
|
23936824 |
2013 |
|
rs10489265
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Discoid
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNPs of TNFSF4 were associated with renal involvement in lupus patients from the Chinese population (P values for rs2205960 and rs10489265 were 0.014 and 0.005 in additive model, resp.).
|
23936824 |
2013 |
|
rs10489265
|
TNFSF4;LOC100506023
|
Encephalitis, St. Louis
|
|
0.010 |
GeneticVariation |
BEFREE |
To replicate the association, two single-nucleotide polymorphisms (SNPs: rs2205960 and rs10489265) were genotyped in 814 SLE patients.
|
23936824 |
2013 |
|
rs704840
|
TNFSF4;LOC100506023
|
Primary Sjögren's syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
Weak associations were observed when the SNPs in TNFSF4 (rs2205960, rs844648 and rs704840) and FAM167A-BLK (rs7812879, rs2254546 and rs2618479) were directly analyzed or analyzed under dominant model between pSS and controls (all P<0.05).
|
23635951 |
2013 |
|
rs844644
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation |
BEFREE |
No association was found between the rs844644 and rs844648 polymorphisms and SLE.
|
22850862 |
2013 |
|
rs844648
|
TNFSF4;LOC100506023
|
Primary Sjögren's syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
Weak associations were observed when the SNPs in TNFSF4 (rs2205960, rs844648 and rs704840) and FAM167A-BLK (rs7812879, rs2254546 and rs2618479) were directly analyzed or analyzed under dominant model between pSS and controls (all P<0.05).
|
23635951 |
2013 |
|
rs10912580
|
TNFSF4;LOC100506023
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype analysis showed that haplotype A(rs844648)A(rs10912580) was significantly associated with breast cancer, even after 10,000 permutations for haplotypes in block only (P = 0.0003).
|
22870213 |
2012 |
|
rs10912580
|
TNFSF4;LOC100506023
|
Systemic Scleroderma
|
|
0.010 |
GeneticVariation |
BEFREE |
Known SLE and SSc TNFSF4 susceptibility variants (rs2205960, rs1234317, rs12039904, rs10912580, and rs844648) were genotyped in 1031 patients with SSc and 1014 controls of French white ancestry.
|
22422496 |
2012 |
|
rs10912580
|
TNFSF4;LOC100506023
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype analysis showed that haplotype A(rs844648)A(rs10912580) was significantly associated with breast cancer, even after 10,000 permutations for haplotypes in block only (P = 0.0003).
|
22870213 |
2012 |
|
rs844648
|
TNFSF4;LOC100506023
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype analysis showed that haplotype A(rs844648)A(rs10912580) was significantly associated with breast cancer, even after 10,000 permutations for haplotypes in block only (P = 0.0003).
|
22870213 |
2012 |
|
rs844648
|
TNFSF4;LOC100506023
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype analysis showed that haplotype A(rs844648)A(rs10912580) was significantly associated with breast cancer, even after 10,000 permutations for haplotypes in block only (P = 0.0003).
|
22870213 |
2012 |
|
rs12039904
|
TNFSF4;LOC100506023
|
Systemic Scleroderma
|
|
0.020 |
GeneticVariation |
BEFREE |
Known SLE and SSc TNFSF4 susceptibility variants (rs2205960, rs1234317, rs12039904, rs10912580, and rs844648) were genotyped in 1031 patients with SSc and 1014 controls of French white ancestry.
|
22422496 |
2012 |
|
rs844648
|
TNFSF4;LOC100506023
|
Systemic Scleroderma
|
|
0.020 |
GeneticVariation |
BEFREE |
Known SLE and SSc TNFSF4 susceptibility variants (rs2205960, rs1234317, rs12039904, rs10912580, and rs844648) were genotyped in 1031 patients with SSc and 1014 controls of French white ancestry.
|
22422496 |
2012 |
|
rs12039904
|
TNFSF4;LOC100506023
|
Systemic Scleroderma
|
|
0.020 |
GeneticVariation |
BEFREE |
A pooled analysis revealed the association of rs1234314 and rs12039904 polymorphisms with SSc (OR 1.15, 95% CI 1.02 to 1.31; OR 1.18, 95% CI 1.08 to 1.29, respectively).
|
21187296 |
2011 |
|
rs844648
|
TNFSF4;LOC100506023
|
Systemic Scleroderma
|
|
0.020 |
GeneticVariation |
BEFREE |
Case-control comparisons revealed a significant association between susceptibility to SSc and the minor alleles at SNPs rs1234314 (OR 1.20, 95% CI 1.04 to 1.4, p(FDR)=0.019), rs2205960 (OR 1.24, 95% CI 1.10 to 1.50, p(FDR)=0.019) and rs844648 (OR 1.16, 95% CI 1.01 to 1.30, p(FDR)=0.032).
|
19778912 |
2010 |
|
rs1099448
|
TNFSF4;LOC100506023
|
Eosinophil count procedure
|
|
0.700 |
GeneticVariation |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
rs2422345
|
TNFSF4;LOC100506023
|
Lupus Erythematosus, Systemic
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.
|
30573655 |
2019 |
|
rs2422345
|
TNFSF4;LOC100506023
|
Myositis
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.
|
30573655 |
2019 |
|
rs2422345
|
TNFSF4;LOC100506023
|
Rheumatoid Arthritis
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.
|
30573655 |
2019 |
|
rs2422345
|
TNFSF4;LOC100506023
|
Systemic Scleroderma
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.
|
30573655 |
2019 |