|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation |
BEFREE |
However, there was no association between rs2292832 (miR-149) polymorphism and BC susceptibility.
|
25483824 |
2015 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation |
BEFREE |
The data showed that the 3746444 GG was associated with increased breast cancer risk (adjusted odds ratio (OR) = 1.71, 95 % confidence interval (CI) = 1.16-2.52) and that rs2292832 CC (adjusted OR = 0.54, 95 % CI = 0.34-0.85) was associated with decreased breast cancer risk.
|
25613069 |
2015 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation |
BEFREE |
The data showed that the 3746444 GG was associated with increased breast cancer risk (adjusted odds ratio (OR) = 1.71, 95 % confidence interval (CI) = 1.16-2.52) and that rs2292832 CC (adjusted OR = 0.54, 95 % CI = 0.34-0.85) was associated with decreased breast cancer risk.
|
25613069 |
2015 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation |
BEFREE |
However, there was no association between rs2292832 (miR-149) polymorphism and BC susceptibility.
|
25483824 |
2015 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Stomach Carcinoma
|
|
0.040 |
GeneticVariation |
BEFREE |
In summary, miR-27a rs895819 and miR-149 rs2292832 are of potential forewarning ability for gastric cancer risk.
|
25795117 |
2015 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Malignant neoplasm of stomach
|
|
0.040 |
GeneticVariation |
BEFREE |
In summary, miR-27a rs895819 and miR-149 rs2292832 are of potential forewarning ability for gastric cancer risk.
|
25795117 |
2015 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Hepatitis B
|
|
0.020 |
GeneticVariation |
BEFREE |
Single Nucleotide Polymorphisms in miR-149 (rs2292832) and miR-101-1 (rs7536540) Are Not Associated with Hepatocellular Carcinoma in Thai Patients with Hepatitis B Virus Infection.
|
26434859 |
2015 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Malignant Head and Neck Neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, no significant association was detected between microRNA-149 rs2292832 C > T and microRNA-499 rs3746444 A > G polymorphism and HNC risk.
|
26277865 |
2015 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Head and Neck Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, no significant association was detected between microRNA-149 rs2292832 C > T and microRNA-499 rs3746444 A > G polymorphism and HNC risk.
|
26277865 |
2015 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation |
BEFREE |
When all the eligible studies were pooled into this meta-analysis, a significant association between MIR-149 gene rs2292832 polymorphism and hepatocellular carcinoma risk was found, while no association was found between this gene polymorphism and overall cancer risk.
|
27348444 |
2016 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation |
BEFREE |
When all the eligible studies were pooled into this meta-analysis, a significant association between MIR-149 gene rs2292832 polymorphism and hepatocellular carcinoma risk was found, while no association was found between this gene polymorphism and overall cancer risk.
|
27348444 |
2016 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation |
BEFREE |
Overall, the results demonstrated that the rs2292832 polymorphism was subtly decrease the risk of breast cancer (CT + CC vs TT: OR = 0.83, 95% CI: 0.70-0.98, P = 0.03; CC vs CT + TT: OR = 0.80, 95% CI: 0.68-0.93, P = 0.00), and the rs895819 polymorphism wasassociated with significantly increased cancer risk in the Asian population (AG + GG vs AA: OR = 1.24, 95% CI: 1.03-1.50, P = 0.02) and in colorectal cancer subgroup (GG vs AA: OR = 1.45, 95% CI: 1.10-1.92, P = 0.00; AG + GG vs AA: OR = 1.35, 95% CI: 1.15-1.58, P = 0.00; GG vs AG + AA: OR = 1.36, 95% CI: 1.04-1.77, P = 0.02).
|
26993779 |
2016 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation |
BEFREE |
Overall, the results demonstrated that the rs2292832 polymorphism was subtly decrease the risk of breast cancer (CT + CC vs TT: OR = 0.83, 95% CI: 0.70-0.98, P = 0.03; CC vs CT + TT: OR = 0.80, 95% CI: 0.68-0.93, P = 0.00), and the rs895819 polymorphism wasassociated with significantly increased cancer risk in the Asian population (AG + GG vs AA: OR = 1.24, 95% CI: 1.03-1.50, P = 0.02) and in colorectal cancer subgroup (GG vs AA: OR = 1.45, 95% CI: 1.10-1.92, P = 0.00; AG + GG vs AA: OR = 1.35, 95% CI: 1.15-1.58, P = 0.00; GG vs AG + AA: OR = 1.36, 95% CI: 1.04-1.77, P = 0.02).
|
26993779 |
2016 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Colorectal Carcinoma
|
|
0.080 |
GeneticVariation |
BEFREE |
However, polymorphisms of miR-149 (rs2292832; CT vs TT: odds ratio [OR] = 0.816, 95% confidence interval [CI] = 0.691-0.963; CC+CT vs TT: OR = 0.834, 95%CI = 0.715-0.972) and pre-miR-27a (rs895819; GG vs AA: OR = 1.534, 95%CI = 1.148-2.049; GG+AG vs AA: OR = 1.324, 95%CI = 1.066-1.645) were found to be associated with CRC in our analysis.
|
27706637 |
2016 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Liver carcinoma
|
|
0.080 |
GeneticVariation |
BEFREE |
Our meta-analysis supports that the MIR-149 gene rs2292832 polymorphism contributed to the risk of HCC from currently available evidence.
|
27348444 |
2016 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation |
BEFREE |
In conclusion, the rs2292832 polymorphism was significantly associated with increased breast cancer</span> risk, and the rs895819 polymorphism contributes to the susceptibility of colorectal and breast cancer.
|
26993779 |
2016 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation |
BEFREE |
In conclusion, the rs2292832 polymorphism was significantly associated with increased breast cancer</span> risk, and the rs895819 polymorphism contributes to the susceptibility of colorectal and breast cancer.
|
26993779 |
2016 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Coronary Artery Disease
|
|
0.030 |
GeneticVariation |
BEFREE |
Furthermore, miR‑149 rs2292832 C>T and miR‑196a2 rs11614913 T>C was shown to increase CAD risk in females and patients aged >63 years old.
|
27430349 |
2016 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Inflammatory Bowel Diseases
|
|
0.020 |
GeneticVariation |
BEFREE |
These findings suggested that mir-146a rs2910164 and mir‑149 rs2292832 may be associated with the increased risk of IBD via alterations in the expression levels of miRNAs.
|
27109937 |
2016 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Congenital atresia of extrahepatic bile duct
|
|
0.010 |
GeneticVariation |
BEFREE |
Of the two single nucleotide polymorphisms (SNPs), we found a significantly decreased BA risk associated with rs2292832 (additive model: OR=0.638, 95% CI: 0.467-0.873, P=0.005), and a marginal effect for rs3828336 (heterozygous model: OR=0.564, 95% CI: 0.312-1.020, P=0.058).
|
27373597 |
2016 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Biliary Atresia
|
|
0.010 |
GeneticVariation |
BEFREE |
Of the two single nucleotide polymorphisms (SNPs), we found a significantly decreased BA risk associated with rs2292832 (additive model: OR=0.638, 95% CI: 0.467-0.873, P=0.005), and a marginal effect for rs3828336 (heterozygous model: OR=0.564, 95% CI: 0.312-1.020, P=0.058).
|
27373597 |
2016 |
|
rs3828336
|
GPC1;LOC100130449
|
Biliary Atresia
|
|
0.010 |
GeneticVariation |
BEFREE |
Of the two single nucleotide polymorphisms (SNPs), we found a significantly decreased BA risk associated with rs2292832 (additive model: OR=0.638, 95% CI: 0.467-0.873, P=0.005), and a marginal effect for rs3828336 (heterozygous model: OR=0.564, 95% CI: 0.312-1.020, P=0.058).
|
27373597 |
2016 |
|
rs3828336
|
GPC1;LOC100130449
|
Congenital atresia of extrahepatic bile duct
|
|
0.010 |
GeneticVariation |
BEFREE |
Of the two single nucleotide polymorphisms (SNPs), we found a significantly decreased BA risk associated with rs2292832 (additive model: OR=0.638, 95% CI: 0.467-0.873, P=0.005), and a marginal effect for rs3828336 (heterozygous model: OR=0.564, 95% CI: 0.312-1.020, P=0.058).
|
27373597 |
2016 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Liver carcinoma
|
|
0.080 |
GeneticVariation |
BEFREE |
To evaluate the association between four common miRNAs (miR-146a rs2910164; miR-149 rs2292832; miR-196a2 rs11614913 and miR-499 rs3746444) and HCC risk, an updated meta-analysis was performed.
|
28499985 |
2017 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Malignant neoplasm of stomach
|
|
0.040 |
GeneticVariation |
BEFREE |
The miR-149 rs2292832 C>T was not associated with susceptibility to gastric cancer, when TT genotype was compared with the more frequent AA genotype (OR 0.98, 95% CI 0.55-1.77, p=0.96) or when we used dominant and recessive models.
|
28523307 |
2017 |